488 research outputs found
Extensions of adaptive slope-seeking for active flow control
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.To speed up gradient estimation in a slope-seeking controller two different modifications are proposed in this study. In a first approach, the gradient estimation is based on a locally identified black-box model. A further improvement is obtained by applying an extended Kalman filter to estimate the local gradient of an input—output map. Moreover, a simple method is outlined to adapt the search radius in the classical extremum- and slope-seeking approach to reduce the perturbations near the optimal state. To show the versatility of the slope-seeking controller for flow control applications two different wind tunnel experiments are considered, namely with a two-dimensional bluff body and a generic three-dimensional car model (Ahmed body).DFG, SFB 557, Beeinflussung komplexer turbulenter Scherströmunge
Photocatalytic degradation of diclofenac in wastewater using ironceramic composites
The photocatalytic degradation of diclofenac in model aqueous solution is investigated. The surface of composites were correlated with photocatalytic activity. Adsorption activity of the composites is related to the presence of surface active sites. The degradation under UV irradiation and photo-Fenton process using ironceramic composites is more effective than direct photolysis
Evidence for Quark-Hadron Duality in the Proton Spin Asymmetry
Spin-dependent lepton-nucleon scattering data have been used to investigate
the validity of the concept of quark-hadron duality for the spin asymmetry
. Longitudinally polarised positrons were scattered off a longitudinally
polarised hydrogen target for values of between 1.2 and 12 GeV and
values of between 1 and 4 GeV. The average double-spin asymmetry in
the nucleon resonance region is found to agree with that measured in
deep-inelastic scattering at the same values of the Bjorken scaling variable
. This finding implies that the description of in terms of quark
degrees of freedom is valid also in the nucleon resonance region for values of
above 1.6 GeV.Comment: 5 pages, 1 eps figure, table added, new references added, in print in
Phys. Rev. Let
The Q^2-Dependence of Nuclear Transparency for Exclusive Production
Exclusive coherent and incoherent electroproduction of the meson
from H and N targets has been studied at the HERMES experiment as a
function of coherence length (), corresponding to the lifetime of hadronic
fluctuations of the virtual photon, and squared four-momentum of the virtual
photon (). The ratio of N to H cross sections per nucleon,
known as nuclear transparency, was found to increase (decrease) with increasing
coherence length for coherent (incoherent) electroproduction. For
fixed coherence length, a rise of nuclear transparency with is observed
for both coherent and incoherent production, which is in agreement
with theoretical calculations of color transparency.Comment: 5 pages, 4 figure
Single-spin Azimuthal Asymmetries in Electroproduction of Neutral Pions in Semi-inclusive Deep-inelastic Scattering
A single-spin asymmetry in the azimuthal distribution of neutral pions
relative to the lepton scattering plane has been measured for the first time in
deep-inelastic scattering of positrons off longitudinally polarized protons.
The analysing power in the sin(phi) moment of the cross section is 0.019 +/-
0.007(stat.) +/- 0.003(syst.). This result is compared to single-spin
asymmetries for charged pion production measured in the same kinematic range.
The pi^0 asymmetry is of the same size as the pi^+ asymmetry and shows a
similar dependence on the relevant kinematic variables. The asymmetry is
described by a phenomenological calculation based on a fragmentation function
that represents sensitivity to the transverse polarization of the struck quark.Comment: 4 pages, 1 figure, replaced to correct eprint author field, 2nd
replacement to correct figure; upper limit of model predictions are
corrected. No correction to data or conclusion
The -dependence of the generalised Gerasimov-Drell-Hearn integral for the deuteron, proton and neutron
The Gerasimov-Drell-Hearn (GDH) sum rule connects the anomalous contribution
to the magnetic moment of the target nucleus with an energy-weighted integral
of the difference of the helicity-dependent photoabsorption cross sections. The
data collected by HERMES with a deuterium target are presented together with a
re-analysis of previous measurements on the proton. This provides a measurement
of the generalised GDH integral covering simultaneously the nucleon-resonance
and the deep inelastic scattering regions. The contribution of the
nucleon-resonance region is seen to decrease rapidly with increasing . The
DIS contribution is sizeable over the full measured range, even down to the
lowest measured . As expected, at higher the data are found to be in
agreement with previous measurements of the first moment of . From data on
the deuteron and proton, the GDH integral for the neutron has been derived and
the proton--neutron difference evaluated. This difference is found to satisfy
the fundamental Bjorken sum rule at GeV.Comment: 12 pages, 10 figure
Франчайзинг как способ эффективного трансфера инноваций (на примере ООО «Сибирская сбытовая компания»)
Франчайзинг в РФ на сегодняшний день стремительно развивается, и это позволяет развиваться малому и среднему бизнесу более активно. Цель работы – исследование франчайзинга как одной из возможных форм развития предпринимательства в том числе засчет эффективного трансфера инноваций компании. В результате исследования сформированы рекомендации для ООО "Сибирская Сбытовая Компания" по дальнейшему развитию. Проведенный анализ и разработанные рекомендации могут быть использованы как ООО "Сибирская сбытовая Компания", так и другими компаниями, планирующими начать бизнес АЗС с помощью франшизы и двигаться далее в направлении инновационного развития.Franchising in the Russian Federation today is rapidly developing, and this allows small and medium-sized businesses to develop more actively. The purpose of the work is to study franchising as one of the possible forms of entrepreneurship development, including through the effective transfer of company innovations. As a result of the study, recommendations were made for Siberian Sales Company LLC for further development. The analysis and recommendations developed can be used both by Siberian Retail Company LLC and other companies planning to start a gas station business with the help of a franchise and move further in the direction of innovative development
Mariner Mars 1969 project report. Volume 2 - Performance Final report
Performance of Mariner Mars 1969 mission by flight and Earth-based elements during launch and space flight phases - Vol.
Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
The phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway is frequently deregulated in pancreatic cancers, and is believed to be an important determinant of their biological aggression and drug resistance. NVP-BEZ235 is a novel, dual class I PI3K/mammalian target of rapamycin (mTor) inhibitor undergoing phase I human clinical trials. To simulate clinical testing, the effects of NVP-BEZ235 were studied in five early passage primary pancreatic cancer xenografts, grown orthotopically. These tumours showed activated PKB/Akt, and increased levels of at least one of the receptor tyrosine kinases that are commonly activated in pancreatic cancers. Pharmacodynamic effects were measured following acute single doses, and anticancer effects were determined in separate groups following chronic drug exposure. Acute oral dosing with NVP-BEZ235 strongly suppressed the phosphorylation of PKB/Akt, followed by recovery over 24 h. There was also inhibition of Ser235/236 S6 ribosomal protein and Thr37/46 4E-BP1, consistent with the effects of NVP-BEZ235 as a dual PI3K/mTor inhibitor. Chronic dosing with 45 mg kg−1 of NVP-BEZ235 was well tolerated, and produced significant tumour growth inhibition in three models. These results predict that agents targeting the PI3K/Akt/mTor pathway might have anticancer activity in pancreatic cancer patients, and support the testing of combination studies involving chemotherapy or other molecular targeted agents
Evolutionarily Conserved Herpesviral Protein Interaction Networks
Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported the protein interaction networks of two herpesviruses, varicella-zoster virus (VZV) and Kaposi's sarcoma-associated herpesvirus (KSHV). In this study, we systematically tested three additional herpesvirus species, herpes simplex virus 1 (HSV-1), murine cytomegalovirus and Epstein-Barr virus, for protein interactions in order to be able to perform a comparative analysis of all three herpesvirus subfamilies. We identified 735 interactions by genome-wide yeast-two-hybrid screens (Y2H), and, together with the interactomes of VZV and KSHV, included a total of 1,007 intraviral protein interactions in the analysis. Whereas a large number of interactions have not been reported previously, we were able to identify a core set of highly conserved protein interactions, like the interaction between HSV-1 UL33 with the nuclear egress proteins UL31/UL34. Interactions were conserved between orthologous proteins despite generally low sequence similarity, suggesting that function may be more conserved than sequence. By combining interactomes of different species we were able to systematically address the low coverage of the Y2H system and to extract biologically relevant interactions which were not evident from single species
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