Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies

Background and Aims: While transarterial chemoembolization (TACE) represents a standard of therapy for intermediate-stage hepatocellular carcinoma (HCC) and is also routinely performed in patients with liver metastases, it is still debated which patients represent the ideal candidates for TACE therapy in terms of overall survival. Sarcopenia, the degenerative loss of skeletal muscle mass and strength, has been associated with an adverse outcome for various malignancies, but its role in the context of TACE has largely remained unknown. Here, we evaluated the role of sarcopenia on the outcome of patients undergoing TACE for primary and secondary liver cancer. Methods: The patients’ psoas muscle size was measured on axial computed tomography (CT) scans and normalized for the patients’ height squared. This value was referred to as the psoas muscle index (PMI). The PMI was correlated with clinical and laboratory markers. Results: While pre-interventional sarcopenia had no impact on the direct tumor response to TACE, sarcopenic patients with a pre-interventional PMI below our ideal cut-o value of 13.39 mm/m2 had a significantly impaired long-term outcome with a median overall survival of 491 days compared to 1291 days for patients with a high PMI. This finding was confirmed by uni- and multivariate Cox-regression analyses. Moreover, a progressive rapid decline in muscle mass after TACE was a predictor for an unfavorable prognosis. Conclusion: Our data suggest that sarcopenia represents a previously unrecognized prognostic factor for patients undergoing TACE therapy which might yield important information on the patients’ post-interventional outcome and should therefore be implemented into clinical stratification algorithms

Electronic structure of intermetallics based on a rare earth element and a transition or noble metal

The results of ab initio study of resonant surface states genesis in the vicinity of Γ point for GdRh[2]Si[2] are presented in this work. Our electronic band structure calculations have shown that the resonant surface states are already formed in three atomic layer slab Si-Rh-Si. The states localization within three layer slab causes its resonant nature and presence of these states on Si- and Gd- termination surfaces

Investigation of fluorescent properties of plasma exosomes in diagnosis and prognosis of colorectal cancer

Exosomes of blood plasma were studied using multiphoton tomography (two-photon microscopy). Exosomes were isolated in patients with colorectal cancer and in healthy donors. Images of fluorescence of exosomes were obtained at a wavelength of 760 nm and second harmonic generation at a wavelength of 380 nm. As a result of the analysis of the obtained data, qualitative differences were found between samples from patients with colorectal cancer and healthy donors

Leyla

Müfide Ferit'in Cumhuriyet'te tefrika edilen Leyla adlı romanıTelif hakları nedeniyle romanın tam metni verilememiştir

Роль информационных технологий в защите окружающей среды и здоровье человека

В этой статье анализируется роль информационных технологий (ИТ) в обеспечении общественного доступа к экологической информации. Также указаны отношения между применением ИТ и уровнем информированности общественности об окружающей среде и влияние этих отношений на охрану окружающей среды. В статье рассматривается роль ИТ в защите здоровья человека.This article analyzes the role of information technology (IT) in providing public access to environmental information. Also, the relationship between the application of IT and the level of public awareness of the environment and the impact of these relations on environmental protection are indicated. The article examines the role of IT in protecting human health

Мониторинг лесных пожаров на территории Томской области

Объект исследования – земли лесного фонда Томской области. Предметом исследования являются пожары на землях лесного фонда Томской области. Основные методы исследования: аналитический, картографический, статистический, дистанционного зондирования Земли. Цель работы: Мониторинг пожароопасности на землях лесного фонда Томской области. Степень изученности вопроса: изучены закономерности назначения лесных угодий и лесного фонда. В процессе исследования проводились анализ и обобщение теоретических и экспериментальных исследований.The object of the study is the land of the forest fund of the Tomsk region. The subject of the study are fires on the lands of the forest fund of the Tomsk region. The main methods of research: analytical, cartographic, statistical, earth sounding. Targeted works: Fire risk monitoring on the lands of the forest fund of the Tomsk region. The degree of study of the issue: the patterns of forest lands and forest resources have been studied. In the process of research, studies and generalizations of theoretical and experimental studies were carried out

Interventional Management of a Renal Cell Carcinoma by Radiofrequency Ablation with Tagging and Cooling

Over the last few years, percutaneous radiofrequency (RF) ablation has been successfully established as a viable treatment modality for small peripheral renal cell carcinoma (RCC). This technique is limited by central tumor location and tumor size. We report the interventional management of a 5.3 cm mixed RCC with central and exophytic parts by combining the RF ablation with embolization, tagging, and retrograde, as well as anterograde cooling. The potential pitfalls of complex hybrid interventions for treating RCC are discussed