A class of auxetic three-dimensional lattices

We propose a class of auxetic three-dimensional lattice structures. The elastic microstructure can be designed in order to have omni-directional Poisson's ratio arbitrarily close to the stability limit -1. The cubic behavior of the periodic system has been fully characterized; the minumum and maximum Poisson's ratio and the associated principal directions are given as a function of the microstructural parameters. The initial microstructure is then modified into a body centered-cubic system that can achieve a Poisson's ratio lower than -1 and that can also behave as an isotropic three-dimensional auxetic structure.Comment: 24 pages, 16 Figures (33 subfigures

Active control of blankholder in sheet metal stamping

Abstract The continuous demand of shape complexity, product accuracy and extended tools life has led to a widespread use of auxiliary systems in sheet metal stamping. Nevertheless, their performances are often inadequate, making their use a compromise between process efficiency and stability. The paper focuses on a new magneto-rheological actuator design. Both analytical and numerical approaches are developed to evaluate load response and to optimize the magnetic field interaction. A physical prototype according to the design outputs is manufactured and tested at different dynamic conditions. Finally, magnetic force values obtained from FE model and experimental tests are compared

Insights in Strain and Stress States of Conical Shapes Flow Forming

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Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression

Electrospun polycaprolactone (PCL) is able to support the adhesion and growth of h-osteoblasts and to delay their degradation rate to a greater extent with respect to other polyesters. The drawbacks linked to its employment in regenerative medicine arise fromits hydrophobic nature and the lack of biochemical signals linked to it. This work reports on the attempt to add five different self-assembling (SA) peptides to PCL solutions before electrospinning. The hybrid scaffolds obtained had regular fibers (SEM analysis) whose diameters were similar to those of the extracellularmatrix, more stable hydrophilic (contact angle measurement) surfaces, and anamorphous phase constrained by peptides (DSC analysis). They appeared to have a notable capacity to promote the h-osteoblast adhesion and differentiation process by increasing the gene expression of alkaline phosphatase, bone sialoprotein, and osteopontin. Adding an Arg-Gly-Asp (RGD) motif to a self-assembling sequence was found to enhance cell adhesion, while the same motif condensed with a scrambled sequence did not, indicating that there is a cooperative effect between RGD and 3D architecture created by the self-assembling peptides. The study demonstrates that self-assembling peptide scaffolds are still able to promote beneficial effects on h-osteoblasts even after they have been included in electrospun polycaprolactone. The possibility of linking biochemical messages to self-assembling peptides could lead the way to a 3D decoration of fibrous scaffolds

Estimation of Nanoporous Au Young's Modulus from Serial Block Face-SEM 3D-Characterisation

Nanoporous Au has been subjected to serial block face-scanning electron microscopy (SBF-SEM) 3D-characterisation. Corresponding sections have been digitalized and used to evaluate the associated mechanical properties. Our investigation demonstrates that the sample is homogeneous and isotropic. The effective Young's modulus estimated by an analytical multiscale approach agrees remarkably well with the values stated in the literature

Bone Turnover in Wild Type and Pleiotrophin-Transgenic Mice Housed for Three Months in the International Space Station (ISS)

Bone is a complex dynamic tissue undergoing a continuous remodeling process. Gravity is a physical force playing a role in the remodeling and contributing to the maintenance of bone integrity. This article reports an investigation on the alterations of the bone microarchitecture that occurred in wild type (Wt) and pleiotrophin-transgenic (PTN-Tg) mice exposed to a near-zero gravity on the International Space Station (ISS) during the Mice Drawer System (MDS) mission, to date, the longest mice permanence (91 days) in space. The transgenic mouse strain over-expressing pleiotrophin (PTN) in bone was selected because of the PTN positive effects on bone turnover. Wt and PTN-Tg control animals were maintained on Earth either in a MDS payload or in a standard vivarium cage. This study revealed a bone loss during spaceflight in the weight-bearing bones of both strains. For both Tg and Wt a decrease of the trabecular number as well as an increase of the mean trabecular separation was observed after flight, whereas trabecular thickness did not show any significant change. Non weight-bearing bones were not affected. The PTN-Tg mice exposed to normal gravity presented a poorer trabecular organization than Wt mice, but interestingly, the expression of the PTN transgene during the flight resulted in some protection against microgravity’s negative effects. Moreover, osteocytes of the Wt mice, but not of Tg mice, acquired a round shape, thus showing for the first time osteocyte space-related morphological alterations in vivo. The analysis of specific bone formation and resorption marker expression suggested that the microgravity-induced bone loss was due to both an increased bone resorption and a decreased bone deposition. Apparently, the PTN transgene protection was the result of a higher osteoblast activity in the flight mice

Raman LIDARs for the atmospheric calibrationalong the line-of-sight of CTA

The Cherenkov Telescope Array (CTA) is the next generation ground-based observatory forgamma-ray astronomy at very-high energies. Employing more than 100 Imaging AtmosphericCherenkov Telescopes in the northern and southern hemispheres, it was designed to reach un-precedented sensitivity and energy resolution. Understanding and correcting for systematic bi-ases on the absolute energy scale and instrument response functions will be a crucial issue forthe performance of CTA. The LUPM group and the Spanish/Italian/Slovenian collaboration arecurrently building two Raman LIDAR prototypes for the online atmospheric calibration alongthe line-of-sight of the CTA. Requirements for such a solution include the ability to characterizeaerosol extinction at two wavelengths to distances of 30 km with an accuracy better than 5%,within time scales of about a minute, steering capabilities and close interaction with the CTAarray control and data acquisition system as well as other auxiliary instruments. Our Raman LI-DARs have design features that make them different from those used in atmospheric science andare characterized by large collecting mirrors (∼2.5 m2), liquid light-guides that collect the light atthe focal plane and transport it to the readout system, reduced acquisition time and highly preciseRaman spectrometers. The Raman LIDARs will participate in a cross-calibration and character-ization campaign of the atmosphere at the CTA North site at La Palma, together with other sitecharacterization instruments. After a one-year test period there, an in-depth evaluation of the so-lutions adopted by the two projects will lead to a final Raman LIDAR design proposal for bothCTA sites