Constraining the evolution of the unstable accretion disk in SMC X-1 with NICER

Neutron star high mass X-ray binaries with superorbital modulations in luminosity host warped inner accretion disks that occult the neutron star during precession. In SMC X-1, the instability in the warped disk geometry causes superorbital period "excursions:" times of instability when the superorbital period decreases from its typical value of 55 days to $\sim$40 days. Disk instability makes SMC X-1 an ideal system in which to investigate the effects of variable disk geometry on the inner accretion flow. Using the high resolution spectral and timing capabilities of the Neutron Star Interior Composition Explorer (NICER) we examined the high state of four different superorbital cycles of SMC X-1 to search forchanges in spectral shape and connections to the unstable disk geometry. We performed pulse phase-averaged and phase-resolved spectroscopy to closely compare the changes in spectral shape and any cycle-to-cycle variations. While some parameters including the photon index and absorbing column density show slight variations with superorbital phase, these changes are most evident during the intermediate state of the supeorbital cycle. Few spectral changes are observed within the high state of the superorbital cycle, possibly indicating the disk instability does not significantly change SMC X-1's accretion process.Comment: 11 pages, 5 figures. Accepted to Ap

The impact of a school-based water supply and treatment, hygiene, and sanitation programme on pupil diarrhoea: a cluster-randomized trial.

The impact of improved water, sanitation, and hygiene (WASH) access on mitigating illness is well documented, although impact of school-based WASH on school-aged children has not been rigorously explored. We conducted a cluster-randomized trial in Nyanza Province, Kenya to assess the impact of a school-based WASH intervention on diarrhoeal disease in primary-school pupils. Two study populations were used: schools with a nearby dry season water source and those without. Pupils attending 'water-available' schools that received hygiene promotion and water treatment (HP&WT) and sanitation improvements showed no difference in period prevalence or duration of illness compared to pupils attending control schools. Those pupils in schools that received only the HP&WT showed similar results. Pupils in 'water-scarce' schools that received a water-supply improvement, HP&WT and sanitation showed a reduction in diarrhoea incidence and days of illness. Our study revealed mixed results on the impact of improvements to school WASH improvements on pupil diarrhoea

An Extreme Black Hole in the Recurrent X-ray Transient XTE J2012+381

The black hole candidate XTE J2012+381 underwent an outburst at the end of 2022. We analyzed 105 NICER observations and 2 NuSTAR observations of the source during the outburst. The NuSTAR observations of the $M \sim10M_\odot$ black hole indicate clear signs of relativistic disk reflection, which we modeled to measure a BH spin of $a=0.988^{+0.008}_{-0.030}$ and an inclination of $\theta=68^{+6}_{-11}$ degrees ($1\sigma$ statistical errors). In our analysis, we test an array of models and examine the effect of fitting NuSTAR spectra alone versus fitting simultaneously with NICER. We find that when the underlying continuum emission is properly accounted for, the reflected emission is similarly characterized by multiple models. We combined 52 NICER spectra to obtain a spectrum with an effective exposure of 190 ks in order to probe the presence of absorption lines that would be suggestive of disk winds, but the resulting features were not statistically significant. We discuss the implications of this measurement in relation to the overall BH spin distribution in X-ray binary systems.Comment: 17 pages, 7 figures. Accepted for publication in Ap

Revealing the spectral state transition of the Clocked Burster, GS 1826-238 with NuSTAR StrayCats

We present the long term analysis of GS 1826-238, a neutron star X-ray binary known as the "Clocked Burster", using data from NuSTAR StrayCats. StrayCats, a catalogue of NuSTAR stray light data, contains data from bright, off-axis X-ray sources that have not been focused by the NuSTAR optics. We obtained stray light observations of the source from 2014-2021, reduced and analyzed the data using nustar-gen-utils Python tools, demonstrating the transition of source from the "island" atoll state to a "banana" branch. We also present the lightcurve analysis of Type I X-Ray bursts from the Clocked Burster and show that the bursts from the banana/soft state are systematically shorter in durations than those from the island/hard state and have a higher burst fluence. From our analysis, we note an increase in mass accretion rate of the source, and a decrease in burst frequency with the transition

Cyclotron line energy in Hercules X-1: stable after the decay

We summarize the results of a dedicated effort made between 2012 and 2019 to follow the evolution of the cyclotron line in Her X-1 through repeated NuSTAR observations. The previously observed nearly 20-year-long decay of the cyclotron line energy has ended in 2012: from then on, the pulse-phase-averaged flux-corrected cyclotron line energy has remained stable and constant at an average value of E_(cyc) = (37.44 ± 0.07) keV (normalized to a flux level of 6.8 RXTE/ASM-cts s⁻¹). The flux dependence of E_(cyc) discovered in 2007 is now measured with high precision, giving a slope of (0.675 ± 0.075) keV/(ASM-cts s⁻¹), corresponding to an increase of 6.5% of E_(cyc) for an increase in flux by a factor of two. We also find that all line parameters as well as the continuum parameters show a correlation with X-ray flux. While a correlation between E_(cyc) and X-ray flux (both positive and negative) is now known for several accreting binaries with various suggestions for the underlying physics, the phenomenon of a long-term decay has so far only been seen in Her X-1 and Vela X-1, with far less convincing explanations

Acute glycogen synthase kinase-3 inhibition modulates human cardiac conduction

Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role for GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB216763, a GSK-3 inhibitor, can acutely reduce conduction velocity in human cardiac slices. Combined computational modeling and experimental approaches provided mechanistic insight into GSK-3 inhibition-mediated changes, revealing that decreased sodium-channel conductance and tissue conductivity may underlie the observed phenotypes. Our study demonstrates that GSK-3 inhibition in human myocardium alters electrophysiology and may predispose to an arrhythmogenic substrate; therefore, monitoring for adverse arrhythmogenic events could be considered

Theoretical Properties of Projection Based Multilayer Perceptrons with Functional Inputs

Many real world data are sampled functions. As shown by Functional Data Analysis (FDA) methods, spectra, time series, images, gesture recognition data, etc. can be processed more efficiently if their functional nature is taken into account during the data analysis process. This is done by extending standard data analysis methods so that they can apply to functional inputs. A general way to achieve this goal is to compute projections of the functional data onto a finite dimensional sub-space of the functional space. The coordinates of the data on a basis of this sub-space provide standard vector representations of the functions. The obtained vectors can be processed by any standard method. In our previous work, this general approach has been used to define projection based Multilayer Perceptrons (MLPs) with functional inputs. We study in this paper important theoretical properties of the proposed model. We show in particular that MLPs with functional inputs are universal approximators: they can approximate to arbitrary accuracy any continuous mapping from a compact sub-space of a functional space to R. Moreover, we provide a consistency result that shows that any mapping from a functional space to R can be learned thanks to examples by a projection based MLP: the generalization mean square error of the MLP decreases to the smallest possible mean square error on the data when the number of examples goes to infinity

Excretion and folding of plasmalemma function to accommodate alterations in guard cell volume during stomatal closure in Vicia faba L.

Stomatal movement results in large and repetitive changes in cell volume and consequently surface area. While endocytosis has been extensively studied and is thought to be a major mechanism for accommodating the volume changes as evidenced mainly by fluorescent labelling and confocal imaging, studies at the ultrastructural level in intact guard cells of stomata regulated by natural factors have never been reported. Here, it is reported that excretion and folding of the plasmalemma are critical for accommodating the volume alterations in intact guard cells in Vicia faba L. Using transmission electron microscopy in combination with laser confocal microscopy, it was observed that in fully opened stomata the plasmalemma was smooth and tightly adhered to the cell walls while a whole large vacuole appeared in the cell. In the closed stomata, besides vacuole fragmentation, endocytosis of the tonoplast rather than the plasmalemma commonly occurred. Importantly, in stomata where pore closure was induced by circadian rhythm or CO2, numerous tiny vesicles were found outside the plasmalemma and, moreover, extensive folding of the plasmalemma could also be found in some regions of the cells. Additionally, an unknown structure was found at the interface between the plasmalemma and cell walls, especially in those areas of the cell where extensive folding occurred, suggesting that plasmalemma turnover is possibly associated with an interaction between the plasmalemma and cell walls. Collectively, the results strongly indicate that excretion and folding of the plasmalemma are critical for the accommodation of the cell volume alterations during stomatal movement