Bounding the Spacecraft Atmosphere Design Space for Future Exploration Missions

The selection of spacecraft and space suit atmospheres for future human space exploration missions will play an important, if not critical, role in the ultimate safety, productivity, and cost of such missions. Internal atmosphere pressure and composition (particularly oxygen concentration) influence many aspects of spacecraft and space suit design, operation, and technology development. Optimal atmosphere solutions must be determined by iterative process involving research, design, development, testing, and systems analysis. A necessary first step in this process is the establishment of working bounds on the atmosphere design space

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue model consisting of filamentous three-dimensional matrices populated with cardiomyocytes derived from healthy wild-type (WT) hiPSCs (WT hiPSC-CMs) or isogenic hiPSCs deficient in the sarcomere protein cardiac myosin-binding protein C (MYBPC3-/- hiPSC-CMs), we show that the WT microtissues adapted to the mechanical environment with increased contraction force commensurate to matrix stiffness, whereas the MYBPC3-/- microtissues exhibited impaired force development kinetics regardless of matrix stiffness and deficient contraction force only when grown on matrices with high fibre stiffness. Under mechanical overload, the MYBPC3-/- microtissues had a higher degree of calcium transient abnormalities, and exhibited an accelerated decay of calcium dynamics as well as calcium desensitization, which accelerated when contracting against stiffer fibres. Our findings suggest that MYBPC3 deficiency and the presence of environmental stresses synergistically lead to contractile deficits in cardiac tissues

Distillation Designs for the Lunar Surface

Gravity-based distillation methods may be applied to the purification of wastewater on the lunar base. These solutions to water processing are robust physical separation techniques, which may be more advantageous than many other techniques for their simplicity in design and operation. The two techniques can be used in conjunction with each other to obtain high purity water. The components and feed compositions for modeling waste water streams are presented in conjunction with the Aspen property system for traditional stage distillation. While the individual components for each of the waste streams will vary naturally within certain bounds, an analog model for waste water processing is suggested based on typical concentration ranges for these components. Target purity levels for recycled water are determined for each individual component based on NASA s required maximum contaminant levels for potable water Optimum parameters such as reflux ratio, feed stage location, and processing rates are determined with respect to the power consumption of the process. Multistage distillation is evaluated for components in wastewater to determine the minimum number of stages necessary for each of 65 components in humidity condensate and urine wastewater mixed streams

Interpersonal prosodic correlation in frontotemporal dementia.

Communication accommodation describes how individuals adjust their communicative style to that of their conversational partner. We predicted that interpersonal prosodic correlation related to pitch and timing would be decreased in behavioral variant frontotemporal dementia (bvFTD). We predicted that the interpersonal correlation in a timing measure and a pitch measure would be increased in right temporal FTD (rtFTD) due to sparing of the neural substrate for speech timing and pitch modulation but loss of social semantics. We found no significant effects in bvFTD, but conversations including rtFTD demonstrated higher interpersonal correlations in speech rate than healthy controls

Analysis of Radioactive Releases During Proposed Demolition Activities for the 224-U and 224-UA Buildings - Addendum

A post-demolition modeling analysis is conducted that compares during-demolition atmospheric concentration monitoring results with modeling results based on the actual meteorological conditions during the demolition activities. The 224-U and 224-UA Buildings that were located in the U-Plant UO3 complex in the 200 West Area of the Hanford Site were demolished during the summer of 2010. These facilities converted uranyl nitrate hexahydrate (UNH), a product of Hanford’s Plutonium-Uranium Extraction (PUREX) Plant, into uranium trioxide (UO3). This report is an addendum to a pre-demolition emission analysis and air dispersion modeling effort that was conducted for proposed demolition activities for these structures

Psychiatrist effects in the psychopharmacological treatment of depression.

Abstract Background: The National Institutes of Mental Health's (NIMH) 1985 Treatment of Depression Collaborative Research Program (TDCRP) reported that imipramine hydrochloride with clinical management (IMI-CM) was significantly more beneficial than placebo with clinical management (PLA-CM) for individuals undergoing treatment for depression. Unfortunately, in analyzing the NIMH TDCRP data, researchers ignored the potential effect that psychiatrists have on patient outcomes, thereby assuming that psychiatrists are equally effective. However, this assumption has yet to be supported empirically. Therefore, the purpose of the current study is to examine psychiatrist effects in the NIMH TDCRP study and to compare the variation among psychiatrists to the variation between treatments. Method: Data from 112 patients [IMI-CM (n = 57, 9 psychiatrists); PLA-CM (n = 55, 9 psychiatrists)] from the NIMH TDCRP study were reanalyzed using a multi-level model. Results: The proportion of variance in the BDI scores due to medication was 3.4% (p b .05), while the proportion of variance in BDI scores due to psychiatrists was 9.1% (p b .05). The proportion of variance in the HAM-D scores due to medication was 5.9% (p b .05), while the proportion of variance in HAM-D scores due to psychiatrist was 6.7% (p = .053). Therefore, the psychiatrist effects were greater than the treatment effects. Conclusions: In this study, both psychiatrists and treatments contributed to outcomes in the treatment of depression. However, given that psychiatrists were responsible for more of the variance in outcomes it can be concluded that effective treatment psychiatrists can, in fact, augment the effects of the active ingredients of anti-depressant medication as well as placebo

The Public's Perspective— Justice Administration 1980: A Survey of Public Opinion

This public opinion survey was commissioned by the Alaska Criminal Justice Planning Agency, Governor's Commission on the Administration of Justice, to help people interested in justice administration in planning, predicting, and educating with respect to the future design and administration of the justice system in Alaska. The survey was conducted during November and December 1979 and included 676 respondents from throughout Alaska. The survey elicited public opinion in four major areas: (1) the climate of public safety, including perceptions of crime rates, public safety, gun ownership, victimization, and family violence; (2) images of the justice professional, including professional skills, professionalism, educational qualifications, discretionary judgments, and discriminatory practices; (3) changes in the law, including the role of public opinion in revision of law, strictness and leniency of laws, perceptions of revisions (including recent revisions in sentencing, the Alaska criminal code, alcohol regulations, and drug laws), perceptions of laws relating to alcohol, marijuana, and other drugs, criminality of gambling and sex offenses, and election of justice officials; and (4) public attitudes toward selected decisions regarding the administration of justice, including law enforcement and corrections priorities, justice services in rural Alaska, consolidation of public safety services, police use of firearms, sentencing, and public education in justice.Prepared under contract number 78-A002 for the Criminal Justice Planning Agency of the Governor's Commission on the Administration of Justice, State of Alaska, with funds provided by the Law Enforcement Assistance Administration, U. S. Department of Justice.Highlights / Introduction / Part I. The Climate of Public Safety / Part II. Images of the System Professional / Part III. Changes in the Law / Part IV. Public Attitudes Towards Selected Operational Decisions and Resource Allocations / APPENDICES / I. Methodology / II. Survey Instrument and Result

Scholars@TAMU Texas A&M University Libraries’

Texas A&M University Libraries has been using VIVO in production since 2015. In that time, we have come up with many creative solutions to meet the needs of our users. In early 2019, we began developing a replacement front end for the VIVO interface to formally address campus demands here at Texas A&M University. Initial requirements: * Align the technology stack as much as possible with the existing VIVO stack to assist with implementation by others if they choose especially smaller libraries. * The majority of the front end is customizable by others. * Read only UI. No updating back to the triple store. * All data is retrieved via a REST API endpoint using Spring Data for Apache Solr. * 100% Search Engine Optimization. IE: A person / crawler can disable JavaScript and still have the same experience. Server side, and Client side rendering if needed

Differential effectiveness of prevalent social work practice models: A meta-analysis

This meta-analysis of 45 recently published (1990–1994) independent studies of social work\u27s differential effectiveness by prevalent practice models builds on the more general findings of related meta-analyses that have estimated that three-quarters of the clients who participate in social work interventions do better than the average client who does not. It found that the effectiveness of interventions based on different practice models—personal versus systemic-structural—was moderated by their primary focus for change. When the focus for change was clients themselves, personal orientations seemed more effective, whereas systemic-structural models were found to be more effective in supporting the change of other targets, such as environmental factors (structural change) rather than personal adaptation to environmental challenges

Evidence for Distinct Components of the Galactic Stellar Halo from 838 RR Lyrae Stars Discovered in the LONEOS-I Survey

We present 838 ab-type RR Lyrae stars from the Lowell Observatory Near Earth Objects Survey Phase I (LONEOS-I). These objects cover 1430 deg^2 and span distances ranging from 3-30 kpc from the Galactic Center. Object selection is based on phased, photometric data with 28-50 epochs. We use this large sample to explore the bulk properties of the stellar halo, including the spatial distribution. The period-amplitude distribution of this sample shows that the majority of these RR Lyrae stars resemble Oosterhoff type I, but there is a significant fraction (26 %) which have longer periods and appear to be Oosterhoff type II. We find that the radial distributions of these two populations have significantly different profiles (rho_{OoI} ~ R^(-2.26 +- 0.07) and rho_{OoII} ~ R^(-2.88 +- 0.11). This suggests that the stellar halo was formed by at least two distinct accretion processes and supports dual-halo models.Comment: 18 pages, 28 figures, apjemulated, minor corrections and clarifications. Accepted to ApJ on Jan 21, 200