Ultracold giant polyatomic Rydberg molecules: coherent control of molecular orientation

We predict the existence of a class of ultracold giant molecules formed from trapped ultracold Rydberg atoms and polar molecules. The interaction which leads to the formation of such molecules is the anisotropic charge-dipole interaction ($a/R^2$). We show that prominent candidate molecules such as KRb and deuterated hydroxyl (OD) should bind to Rydberg rubidium atoms, with energies $E_b\simeq 5-25$ GHz at distances $R\simeq 0.1-1 \ \mu$m. These molecules form in double wells, mimicking chiral molecules, with each well containing a particular dipole orientation. We prepare a set of correlated dressed electron-dipole eigenstates which are used in a resonant Raman scheme to coherently control the dipole orientation and to create cat-like entangled states of the polar molecule.Comment: 4 pages, 4 figure

The Power Control Rack: A Modular Solution for Building Power Systems

LDRD proposal presentation to ETA ALD at LBNL. Proposing use of SST to create a modular efficient single point of common coupling for buildings

Hampton Roads Residents’ Preferences for Dune and Beach Management

The management of dunes and beaches in Hampton Roads is critical to the region’s tourism industry and to provide protection from storms and flooding. During the summer of 2017, we surveyed over 675 residents of Hampton Roads to gauge their preferences for the management of dunes and beaches. An overwhelming majority felt that all taxpayers should have a say in maintenance practices along with government regulations to assist with the protection of beaches and dunes. Residents leaned towards localized input from citizens as preferred methods of management and understood the importance their tax dollars play in funding those methods. While residents supported the maintenance of dunes and beaches, there is a split on the appropriate methods to be used. In addition, the majority of participants were supportive of new taxes to fund beach protection

Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Drugs such as proteins and peptides that are known to degrade in the extreme gastric pH, if delivered to the colon intact, can be systemically absorbed by colonic mucosa. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Several formulation approaches have been explored in the development colon-targeted drug delivery systems. These approaches involve the use of formulation components that interact with one or more aspects of gastrointestinal (GI) physiology, such as the difference in the pH along the GI tract, the presence of colonic microflora, and enzymes, to achieve colon targeting. This article highlights the factors influencing colon-specific drug delivery and colonic bioavailability, and the limitations associated with CDDS. Further, the review provides a systematic discussion of various conventional, as well as relatively newer formulation approaches/technologies currently being utilized for the development of CDDS

Swagelok\u27s Hand Tube Bender

In our project, we are assigned to develop a hand tube bender that is able to bend medium, high pressure, and standard 1/4” and 3/8” tubing. The bender also shall be capable of being used with two hands without the aid of a bench vise and have provisions for use in a bench vise for convenience. The bender shall not damage the tube during bending and induce a maximum of 8% ovality in the bent tubing. In addition, the cost of the bender shall be less than the existing hand tube bender and be resistant to rusting from ordinary use. The first step of our plan is to develop our conceptual designs by brainstorming and analyzing the function structure diagram of the hand tube bender in order to give us an idea how the bender works. Moreover, we created an objective tree to fulfill the expected needs of both customers and the manufacturer. We also developed our morphological chart based on our function solutions from function structure diagram and created four different possible designs for our project. Each design that we developed will be used in the weighted design matrix with specific criteria we developed in our objective tree so that we are able to choose the best design that is most suitable for our criteria. After selecting a single design, we will continue our project by developing our embodiment design. In our embodiment design, we start to add our design with the detailed layout of functions and connecting methods. We will also calculate the force and give an estimated cost for our bender so that we could calculate the total cost to produce the bender. In the second part of our project, we continued our plan by selecting a material for all components of our design. The materials chosen are based on their ability to fulfill the requirements of the project. After which we developed our prototype design in 3D CAD software in order to have a visual model that we can validate and improve upon. We continued our project by manufacturing prototypes and testing them. We performed three distinctive tests for validation of our prototypes. A bending test was performed to measure the ovality of the bent tubing and the maximum torque to bend. Secondly we tested the strength of the benders by attempting to bend hardened drill rod. Finally, a salt spray test was performed to validate the corrosion resistance of the benders

Clinical Supervisors\u27 Knowledge of Supervisees with Problems of Professional Competency

In this exploratory study, the authors surveyed clinical supervisors (n = 138) regarding their knowledge of their supervisees’ problems of professional competency (PPC). Findings suggest the majority have observed a supervisee with PPC working towards licensure. Further, those that have supervised a supervisee with PPC have been negatively impacted by these interactions (e.g., increased their workload, increased their stress)

Gravity and BF theory defined in bounded regions

We study Einstein gravity in a finite spatial region. By requiring a well-defined variational principle, we identify all local boundary conditions, derive surface observables, and compute their algebra. The observables arise as induced surface terms, which contribute to a non-vanishing Hamiltonian. Unlike the asymptotically flat case, we find that there are an infinite number of surface observables. We give a similar analysis for SU(2) BF theory.Comment: References adde

Evolution of the holozoan ribosome biogenesis regulon

<p>Abstract</p> <p>Background</p> <p>The ribosome biogenesis (RiBi) genes encode a highly-conserved eukaryotic set of nucleolar proteins involved in rRNA transcription, assembly, processing, and export from the nucleus. While the mode of regulation of this suite of genes has been studied in the yeast, <it>Saccharomyces cerevisiae</it>, how this gene set is coordinately regulated in the larger and more complex metazoan genomes is not understood.</p> <p>Results</p> <p>Here we present genome-wide analyses indicating that a distinct mode of RiBi regulation co-evolved with the E(CG)-binding, Myc:Max bHLH heterodimer complex in a stem-holozoan, the ancestor of both Metazoa and Choanoflagellata, the protozoan group most closely related to animals. These results show that this mode of regulation, characterized by an E(CG)-bearing core-promoter, is specific to almost all of the known genes involved in ribosome biogenesis in these genomes. Interestingly, this holozoan RiBi promoter signature is absent in nematode genomes, which have not only secondarily lost Myc but are marked by invariant cell lineages typically producing small body plans of 1000 somatic cells. Furthermore, a detailed analysis of 10 fungal genomes shows that this holozoan signature in RiBi genes is not found in hemiascomycete fungi, which evolved their own unique regulatory signature for the RiBi regulon.</p> <p>Conclusion</p> <p>These results indicate that a Myc regulon, which is activated in proliferating cells during normal development as well as during tumor progression, has primordial roots in the evolution of an inducible growth regime in a protozoan ancestor of animals. Furthermore, by comparing divergent bHLH repertoires, we conclude that regulation by Myc but not by other bHLH genes is responsible for the evolutionary maintenance of E(CG) sites across the RiBi suite of genes.</p