Manual-assisted cognitive therapy for self-harm in personality disorder and substance misuse: a feasibility trial

<b>Aims and method</b> To assess the feasibility of conducting a larger, definitive randomised controlled trial of manual-assisted cognitive therapy (MACT), a brief focused therapy to address self-harm and promote engagement in services. We established recruitment, randomisation and assessment of outcome within a sample of these complex patients admitted to a general hospital following self-harm. We assessed symptoms of depressed mood, anxiety and suicidality at baseline and at 3 months’ follow-up.<p></p> <b>Results</b> Twenty patients were randomised to the trial following an index episode of self-harm, and those allocated to MACT demonstrated improvement in anxiety, depression and suicidal ideation.<p></p> <b>Clinical implications</b> It is feasible to recruit a sample of these complex patients to a randomised controlled trial of MACT following an index episode of self-harm. There is preliminary support that MACT could be an acceptable and effective intervention in patients with personality disorder and substance misuse

Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water

By confining water in nano-pores of silica glass, we can bypass the crystallization and study the pressure effect on the dynamical behavior in deeply supercooled state using neutron scattering. We observe a clear evidence of a cusp-like fragile-to-strong (F-S) dynamic transition. Here we show that the transition temperature decreases steadily with an increasing pressure, until it intersects the homogenous nucleation temperature line of bulk water at a pressure of 1600 bar. Above this pressure, it is no longer possible to discern the characteristic feature of the F-S transition. Identification of this end point with the possible second critical point is discussed.Comment: 4 pages, 3 figure

Notes on the diet and reproduction of the bark scorpion \u3cem\u3eCentruroides gracilis\u3c/em\u3e (Scorpiones: Buthidae) on Utila Island, Honduras

The brown bark scorpion Centruroides gracilis (Latreille, 1804) (Buthidae) is an abundant and widespread species, however, fairly little is known about its ecology and natural history. We include several observations from Utila Island, Honduras, that expand on the known literature regarding the diet and reproductive behavior of C. gracilis. We report several prey items for this opportunistic species, which include invertebrates such as spiders (including tarantulas), centipedes, katydids, and crickets; as well as a case of cannibalism between two adult females C. gracilis. We suggest that such cannibalism may be driven by high population densities and/or strong intraspecific competition for prey sources on the island. Additionally, we observed a courtship dance involving a female that still carried second-instar offspring, a common behavior within the Buthidae family, although, to our knowledge, not previously reported for C. gracilis

Quantifying the value of ecosystem services: a case study of honeybee pollination in the UK

There is concern that insect pollinators, such as honey bees, are currently declining in abundance, and are under serious threat from environmental changes such as habitat loss and climate change; the use of pesticides in intensive agriculture, and emerging diseases. This paper aims to evaluate how much public support there would be in preventing further decline to maintain the current number of bee colonies in the UK. The contingent valuation method (CVM) was used to obtain the willingness to pay (WTP) for a theoretical pollinator protection policy. Respondents were asked whether they would be WTP to support such a policy and how much would they pay? Results show that the mean WTP to support the bee protection policy was £1.37/week/household. Based on there being 24.9 million households in the UK, this is equivalent to £1.77 billion per year. This total value can show the importance of maintaining the overall pollination service to policy makers. We compare this total with estimates obtained using a simple market valuation of pollination for the UK

Poor Quality of Instruction Leads to Poor Motor Performance Regardless of Internal or External Focus of Attention

International Journal of Exercise Science 9(2): 214-222, 2016. The view that external focus of attention provides beneficial performance outcomes when compared to an internal focus of attention has been consistently supported in the movement performance literature. While type of focus has been well investigated, the current study examined the influence of quality of instruction as a variation of the type of focus. Specifically, the purpose of the study investigated how performance-enhancing instructions would differ from performance-neutral instructions on an agility performance. An agility L-run was used to measure performance in the four counterbalanced conditions: Internal-Performance Neutral (INT-PN), Internal-Performance Enhancing (INT-PE), External-Performance Neutral (EXT-PN) and External-Performance Enhancing (EXT-PE). These conditions were designed to provide insight into the influence of quality of instruction on performance. The mean times for both EXT-PN (6.76 s) and INT-PN (6.86 s) conditions were significantly slower than the EXT-PE (6.59 s) and INT-PE (6.65 s) conditions, respectively. Additionally, no differences were observed between the EXT-PE and INT-PE conditions. These results demonstrate the negative impact that poor quality of instruction can have on performance

Meteorological conditions during periods of low wind speed and insolation in Germany: The role of weather regimes

Renewable power generation from wind and solar energy is strongly dependent on the weather. To plan future sustainable energy systems that are robust to weather variability, a better understanding of why and when periods of low wind and solar power output occur is valuable. We call such periods of low wind speed and insolation “Dunkelflauten”, the German word for “dark wind lulls”. In this article, we analyse the meteorological conditions during Dunkelflauten in Germany by applying the concept of weather regimes. Weather regimes are quasi-stationary, recurrent and persistent large-scale circulation patterns that explain multi-day atmospheric variability (5–15 days). We use a regime definition that allows us to distinguish four different types of blocked regimes, characterized by high-pressure situations in the North Atlantic-European region. We find that Dunkelflauten in Germany occur mainly in winter when the solar power output is low due to the seasonal cycle of solar irradiance and wind power output drops for several consecutive days. A high-pressure system over Germany, associated with the European Blocking regime, is responsible for most of the Dunkelflauten. Dunkelflauten during the Greenland Blocking regime are associated with colder temperatures than usual, causing higher electricity demand, and would present a particular challenge as space heating becomes electrified in the future. Furthermore, we show that Dunkelflauten occur predominantly when a weather regime is well established and persists longer than usual. Our study provides novel insight into the occurrence and meteorological characteristics of Dunkelflauten, which is essential for planning resilient energy systems and supporting grid operators to prepare for potential shortages in supply

Meteorological conditions during Dunkelflauten in Germany: Characteristics, the role of weather regimes and impacts on demand

Renewable generation from wind and solar power is strongly weather-dependent. To plan future sustainable energy systems that are robust to this variability, a better understanding of why and when periods of low wind and solar power output occur is valuable. We call such periods of low wind and solar power output `Dunkelflauten', the German word for dark wind lulls. In this article, we analyse the meteorological conditions during Dunkelflauten in Germany by applying the concept of weather regimes. Weather regimes are quasi-stationary, recurrent, and persistent large-scale circulation patterns which explain multi-day atmospheric variability (5-15 days). We use a regime definition that allows us to distinguish four different types of blocked regimes, characterised by high pressure situations in the North Atlantic-European region. We find that in Germany, Dunkelflauten mainly occur in winter when the solar power output is anyway low and when the wind power output drops for several consecutive days. A high-pressure system over Germany, associated with the European Blocking regime, is responsible for most of the Dunkelflauten. Dunkelflauten during the Greenland Blocking regime are associated with colder temperatures than usual, causing higher electricity demand and presenting a particular challenge as space heating demand electrifies in future. Furthermore, we show that Dunkelflauten occur predominantly when a weather regime is well-established and persists longer than usual. Our study provides novel insight on the occurrence and meteorological characteristics of Dunkelflauten, which is essential for planning resilient energy systems and supporting grid operators to prepare for potential shortages in supply.Comment: 20pages, 11figures, submitted to "Meteorological Applications" by Royal Meteorological Society (https://rmets.onlinelibrary.wiley.com/journal/14698080

Measles vaccination and antibody response in autism spectrum disorder

OBJECTIVE: To test the hypothesis that measles vaccination was involved in the pathogenesis of autism spectrum disorders (ASD) as evidenced by signs of a persistent measles infection or abnormally persistent immune response shown by circulating measles virus or raised antibody titres in children with ASD who had been vaccinated against measles, mumps and rubella (MMR) compared with controls. DESIGN: Case-control study, community based. METHODS: A community sample of vaccinated children aged 10-12 years in the UK with ASD (n = 98) and two control groups of similar age, one with special educational needs but no ASD (n = 52) and one typically developing group (n = 90), were tested for measles virus and antibody response to measles in the serum. RESULTS: No difference was found between cases and controls for measles antibody response. There was no dose-response relationship between autism symptoms and antibody concentrations. Measles virus nucleic acid was amplified by reverse transcriptase-PCR in peripheral blood mononuclear cells from one patient with autism and two typically developing children. There was no evidence of a differential response to measles virus or the measles component of the MMR in children with ASD, with or without regression, and controls who had either one or two doses of MMR. Only one child from the control group had clinical symptoms of possible enterocolitis. CONCLUSION: No association between measles vaccination and ASD was shown

Sintering of calcium phosphates with a femtosecond pulsed laser for hard tissue engineering

The authors acknowledge support from the sponsors of this work; the EPSRC LUMIN (EP/K020234/1) and EU-Marie-Curie-IAPP LUSTRE (324538) projects.Direct laser sintering on hard tissues is likely to open new pathways for personalised medicine. To minimise irradiation damage of the surrounding soft tissues, lasers operating at wavelengths that are ‘safe’ for the tissues and biomaterials with improved optical properties are required. In this work laser sintering is demonstrated with the use of an ultrafast, femtosecond (100 fs) pulsed laser operating at a wavelength of 1045 nm and two existing calcium phosphate minerals (brushite and hydroxyapatite) which have been improved after doping with iron (10 mol%). Femtosecond laser irradiation caused transformation of the Fe3+-doped brushite and Fe3+-doped HAp samples into β-calcium pyrophosphate and calcium-iron-phosphate, respectively, with simultaneous evidence for microstructural sintering and densification. After estimating the temperature profile at the surface of the samples we suggest that soft tissues over 500 μm from the irradiated zone would be safe from thermal damage. This novel laser processing provides a means to control the phase constitution and the morphology of the finished surfaces. The porous structure of β-pyrophosphate might be suitable for applications in bone regeneration by supporting osteogenic cell activity while, the densified Fe3+-rich calcium-iron-phosphate may be promising for applications like dental enamel restoration.PostprintPeer reviewe