Facilitating goal-oriented behaviour in the Stroop task: when executive control is influenced by automatic processing.

A portion of Stroop interference is thought to arise from a failure to maintain goal-oriented behaviour (or goal neglect). The aim of the present study was to investigate whether goal- relevant primes could enhance goal maintenance and reduce the Stroop interference effect. Here it is shown that primes related to the goal of responding quickly in the Stroop task (e.g. fast, quick, hurry) substantially reduced Stroop interference by reducing reaction times to incongruent trials but increasing reaction times to congruent and neutral trials. No effects of the primes were observed on errors. The effects on incongruent, congruent and neutral trials are explained in terms of the influence of the primes on goal maintenance. The results show that goal priming can facilitate goal-oriented behaviour and indicate that automatic processing can modulate executive control

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been extensively analyzed as TRAIL sensitizers, particularly in TRAIL-resistant renal cell carcinoma cells. Evaluation of rocaglamide and analogs identified 29 compounds that are able to sensitize TRAIL-resistant ACHN cells to TRAIL-induced, caspase-dependent apoptosis with sub-µM potency which correlated with their potency as protein synthesis inhibitors and with loss of cFLIP protein in the same cells. Rocaglamide alone induced cell cycle arrest, but not apoptosis. Rocaglates averaged 4–5-fold higher potency as TRAIL sensitizers than as protein synthesis inhibitors suggesting a potential window for maximizing TRAIL sensitization while minimizing effects of general protein synthesis inhibition. A wide range of other rocaglate effects (e.g. on JNK or RAF-MEK-ERK signaling, death receptor levels, ROS, ER stress, eIF4E phosphorylation) were assessed, but did not contribute to TRAIL sensitization. Other than a rapid loss of MCL-1, rocaglates had minimal effects on mitochondrial apoptotic pathway proteins. The identification of structurally diverse/mechanistically similar TRAIL sensitizing rocaglates provides insights into both rocaglate structure and function and potential further development for use in RCC-directed combination therapy.This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research. Research performed at Boston University was supported in part by NIH R35 GM118173. Work at the BU-CMD is supported by R24 GM111625. (HHSN261200800001E - National Cancer Institute, National Institutes of Health; Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research; R35 GM118173 - NIH; R24 GM111625)Published versio

Verification of TG-61 dose for synchrotron-produced monochromatic x-ray beams using fluence-normalized MCNP5 calculations

Ion chamber dosimetry is being used to calibrate dose for cell irradiations designed to investigate photoactivated Auger electron therapy at the Louisiana State University CAMD synchrotron facility. This study performed a dosimetry intercomparison for synchrotron-produced monochromatic x-ray beams at 25 and 35 keV. Ion chamber depth-dose measurements in a PMMA phantom were compared with the product of MCNP5 Monte Carlo calculations of dose per fluence and measured incident fluence. Monochromatic beams of 25 and 35 keV were generated on the tomography beamline at CAMD. A cylindrical, air-equivalent ion chamber was used to measure the ionization created in a 10x10x10-cm3 PMMA phantom for depths from 0.6 to 7.7 cm. The American Association of Physicists in Medicine TG-61 protocol was applied to convert measured ionization into dose. Photon fluence was determined using a NaI detector to make scattering measurements of the beam from a thin polyethylene target at angles 30 degrees to 60 degrees. Differential Compton and Rayleigh scattering cross sections obtained from xraylib, an ANSI C library for x-ray-matter interactions, were applied to derive the incident fluence. MCNP5 simulations of the irradiation geometry provided the dose deposition per photon fluence as a function of depth in the phantom. At 25 keV the fluence-normalized MCNP5 dose overestimated the ion-chamber measured dose by an average of 7.2+/-3.0% to 2.1+/-3.0% for PMMA depths from 0.6 to 7.7 cm, respectively. At 35 keV the fluence-normalized MCNP5 dose underestimated the ion-chamber measured dose by an average of 1.0+/-3.4% to 2.5+/-3.4%, respectively. These results showed that TG-61 ion chamber dosimetry, used to calibrate dose output for cell irradiations, agreed with fluence-normalized MCNP5 calculations to within approximately 7% and 3% at 25 and 35 keV, respectively.Comment: 22 pages, 5 figure

Modelling and characterization of cell collapse in aluminium foams during dynamic loading

Plate-impact experiments have been conducted to investigate the elastic–plastic behaviour of shock wave propagation and pore collapse mechanisms of closed-cell aluminium foams. FE modelling using a meso-scale approach has been carried out with the FE software ABAQUS/Explicit. A micro-computed tomography-based foam geometry has been developed and microstructural changes with time have been investigated to explore the effects of wave propagation. Special attention has been given to the pore collapse mechanism. The effect of velocity variations on deformation has been elucidated with three different impact conditions using the plate-impact method. Free surface velocity (ufs) was measured on the rear of the sample to understand the evolution of the compaction. At low impact velocities, the free-surface velocity increased gradually, whereas an abrupt rise of free-surface velocity was found at an impact velocity of 845 m/s with a copper flyer-plate which correlates with the appearance of shock. A good correlation was found between experimental results and FE predictions

Color--Luminosity Relations for the Resolved Hot Stellar Populations in the Centers of M 31 and M 32

We present Faint Object Camera (FOC) ultraviolet images of the central 14x14'' of Messier 31 and Messier 32. The hot stellar population detected in the composite UV spectra of these nearby galaxies is partially resolved into individual stars, and their individual colors and apparent magnitudes are measured. We detect 433 stars in M 31 and 138 stars in M 32, down to detection limits of m_F275W = 25.5 mag and m_F175W = 24.5 mag. We investigate the luminosity functions of the sources, their spatial distribution, their color-magnitude diagrams, and their total integrated far-UV flux. Although M 32 has a weaker UV upturn than M 31, the luminosity functions and color-magnitude diagrams of M 31 and M 32 are surprisingly similar, and are inconsistent with a majority contribution from any of the following: PAGB stars more massive than 0.56 Msun, main sequence stars, or blue stragglers. Both the the luminosity functions and color-magnitude diagrams are consistent with a dominant population of stars that have evolved from the extreme horizontal branch (EHB) along tracks with masses between 0.47 and 0.53 Msun. These stars are well below the detection limits of our images while on the zero-age EHB, but become detectable while in the more luminous (but shorter) AGB-Manque' and post-early asymptotic giant branch (PEAGB) phases. The FOC observations require that only a only a very small fraction of the main sequence population (2% in M 31 and 0.5% in M 32) in these two galaxies evolve though the EHB and post-EHB phases, with the remainder evolving through bright PAGB evolution that is so rapid that few if any stars are expected in the small field of view covered by the FOC.Comment: 35 pages, Latex. 19 figures. To appear in ApJ. Uses emulateapj.sty and apjfonts.sty (included). Color plates distributed seperatedly: fig1.jpg and fig2.jp

Positivity of Entropy in the Semi-Classical Theory of Black Holes and Radiation

Quantum stress-energy tensors of fields renormalized on a Schwarzschild background violate the classical energy conditions near the black hole. Nevertheless, the associated equilibrium thermodynamical entropy $\Delta S$ by which such fields augment the usual black hole entropy is found to be positive. More precisely, the derivative of $\Delta S$ with respect to radius, at fixed black hole mass, is found to vanish at the horizon for {\it all} regular renormalized stress-energy quantum tensors. For the cases of conformal scalar fields and U(1) gauge fields, the corresponding second derivative is positive, indicating that $\Delta S$ has a local minimum there. Explicit calculation shows that indeed $\Delta S$ increases monotonically for increasing radius and is positive. (The same conclusions hold for a massless spin 1/2 field, but the accuracy of the stress-energy tensor we employ has not been confirmed, in contrast to the scalar and vector cases). None of these results would hold if the back-reaction of the radiation on the spacetime geometry were ignored; consequently, one must regard $\Delta S$ as arising from both the radiation fields and their effects on the gravitational field. The back-reaction, no matter how "small",Comment: 19 pages, RevTe

Measurements of the Diffuse Ultraviolet Background and the Terrestrial Airglow with the Space Telescope Imaging Spectrograph

Far-UV observations in and near the Hubble Deep Fields demonstrate that the Space Telescope Imaging Spectrograph (STIS) can potentially obtain unique and precise measurements of the diffuse far-ultraviolet background. Although STIS is not the ideal instrument for such measurements, high-resolution images allow Galactic and extragalactic objects to be masked to very faint magnitudes, thus ensuring a measurement of the truly diffuse UV signal. The programs we have analyzed were not designed for this scientific purpose, but would be sufficient to obtain a very sensitive measurement if it were not for a weak but larger-than-expected signal from airglow in the STIS 1450-1900 A bandpass. Our analysis shows that STIS far-UV crystal quartz observations taken near the limb during orbital day can detect a faint airglow signal, most likely from NI\1493, that is comparable to the dark rate and inseparable from the far-UV background. Discarding all but the night data from these datasets gives a diffuse far-ultraviolet background measurement of 501 +/- 103 ph/cm2/sec/ster/A, along a line of sight with very low Galactic neutral hydrogen column (N_HI = 1.5E20 cm-2) and extinction (E(B-V)=0.01 mag). This result is in good agreement with earlier measurements of the far-UV background, and should not include any significant contribution from airglow. We present our findings as a warning to other groups who may use the STIS far-UV camera to observe faint extended targets, and to demonstrate how this measurement may be properly obtained with STIS.Comment: 7 pages, Latex. 4 figures. Uses corrected version of emulateapj.sty and apjfonts.sty (included). Accepted for publication in A