Communities of Practice in the Public-Private-Partnership Sector for Neglected Diseases Drug Development: the Importance of Mindset Mapping

This research article explores the mindsets of Public-Private Partnerships and Clinical Trials Organizations (CTOs) and the potential conflicts when working on drug discovery and development in the Third World global infectious diseases sector. A Communities-of-Practice (CoP) approach has been adopted to more fully explore the underlying values, attitudes and practices of these two future partners. This exploratory study suggests that future collaboration will be dependent on the two communities understanding and interpretation of each others‟ sustainability drug development drivers. The authors present secondary research findings that suggest the positive contribution that cognitive mapping of a community‟s sense-making can have in understanding the community‟s likely engagement in any future joint enterprise. Proposed future research will explore the underlying sustainability drivers that may both push and pull CTOs to engage in future global infectious diseases discovery and development projects. The article concludes by discussing the implications for future sustainable drug development projects involving PPPs and potential new strategic partners

Parity Violation in Astrophysics

Core collapse supernovae are gigantic explosions of massive stars that radiate 99% of their energy in neutrinos. This provides a unique opportunity for large scale parity or charge conjugation violation. Parity violation in a strong magnetic field could lead to an asymmetry in the neutrino radiation and recoil of the newly formed neutron star. Charge conjugation violation in the neutrino-nucleon interaction reduces the ratio of neutrons to protons in the neutrino driven wind above the neutron star. This is a problem for r-process nucleosynthesis in this wind. On earth, parity violation is an excellent probe of neutrons because the weak charge of a neutron is much larger than that of a proton. The Parity Radius Experiment (PREX) at Jefferson Laboratory aims to precisely measure the neutron radius of $^{208}$Pb with parity violating elastic electron scattering. This has many implications for astrophysics, including the structure of neutron stars, and for atomic parity nonconservation experiments.}Comment: 4 pages, 2 figures, proceedings of PAVI04 conference in Grenoble, Franc

Food choice and diet of the bearded vulture Gypaetus barbatus in southern Africa

When offered a selection of food items, bearded vultures Gypaetus barbatus in southern Africa chose bones in preference to meat or to feeding from a fleshed carcass. Once a carcass had been stripped of soft tissue by Gyps vultures, bearded vultures disarticulated sections or individual bones (depending on the size of the dead animal) in the order: limbs, ribs, vertebrae, skull. Their overall diet was estimated as 70% bone with marrow, 25% meat and 5% skin. This diet is about 15% higher in energy than an equivalent mass of meat. Of 683 identified prey items from five sources of data, over 80% consisted of domestic livestock; about 60% of this was sheep and goats. Even birds nesting within conservation areas derived more than half of their food from domestic stock which they found by foraging over adjacent commercial and subsistence farming areas. Bearded vultures obtain all their food by scavenging, and reports of attacks on live animals and even humans are rejected

Biodiversity of nematode assemblages from the region of the Clarion-Clipperton Fracture Zone, an area of commercial mining interest

BACKGROUND: The possibility for commercial mining of deep-sea manganese nodules is currently under exploration in the abyssal Clarion-Clipperton Fracture Zone. Nematodes have potential for biomonitoring of the impact of commercial activity but the natural biodiversity is unknown. We investigate the feasibility of nematodes as biomonitoring organisms and give information about their natural biodiversity. RESULTS: The taxonomic composition (at family to genus level) of the nematode fauna in the abyssal Pacific is similar, but not identical to, the North Atlantic. Given the immature state of marine nematode taxonomy, it is not possible to comment on the commonality or otherwise of species between oceans. The between basin differences do not appear to be directly linked to current ecological factors. The abyssal Pacific region (including the Fracture Zone) could be divided into two biodiversity subregions that conform to variations in the linked factors of flux to the benthos and of sedimentary characteristics. Richer biodiversity is associated with areas of known phytodetritus input and higher organic-carbon flux. Despite high reported sample diversity, estimated regional diversity is less than 400 species. CONCLUSION: The estimated regional diversity of the CCFZ is a tractable figure for biomonitoring of commercial activities in this region using marine nematodes, despite the immature taxonomy (i.e. most marine species have not been described) of the group. However, nematode ecology is in dire need of further study

Diffeomorphisms as Symplectomorphisms in History Phase Space: Bosonic String Model

The structure of the history phase space $\cal G$ of a covariant field system and its history group (in the sense of Isham and Linden) is analyzed on an example of a bosonic string. The history space $\cal G$ includes the time map $\sf T$ from the spacetime manifold (the two-sheet) $\cal Y$ to a one-dimensional time manifold $\cal T$ as one of its configuration variables. A canonical history action is posited on $\cal G$ such that its restriction to the configuration history space yields the familiar Polyakov action. The standard Dirac-ADM action is shown to be identical with the canonical history action, the only difference being that the underlying action is expressed in two different coordinate charts on $\cal G$. The canonical history action encompasses all individual Dirac-ADM actions corresponding to different choices $\sf T$ of foliating $\cal Y$. The history Poisson brackets of spacetime fields on $\cal G$ induce the ordinary Poisson brackets of spatial fields in the instantaneous phase space ${\cal G}_{0}$ of the Dirac-ADM formalism. The canonical history action is manifestly invariant both under spacetime diffeomorphisms Diff$\cal Y$ and temporal diffeomorphisms Diff$\cal T$. Both of these diffeomorphisms are explicitly represented by symplectomorphisms on the history phase space $\cal G$. The resulting classical history phase space formalism is offered as a starting point for projection operator quantization and consistent histories interpretation of the bosonic string model.Comment: 45 pages, no figure

Sand moisture as a factor determining depth of burrowing in the oniscid isopod Tylos granulatus Krauss

Tylos granulatus, a sandy-beach isopod, prefers an environmental moisture range exceeding 3,4% but less than 13%. The depths to which the animals burrow are, at least partly, determined by the moisture gradient in the sand. They are, however, incapable of burrowing into lotally dry sand. Animals alter their position in the sand in response to changes in moisture content so as to ensure exposure to suitable conditions

Correlated GNSS and temperature measurements at 10-minute intervals on the Severn Suspension Bridge

Global Navigation Satellite System (GNSS) data were gathered on the 998-m-long Severn Suspension Bridge main span. The antennas were located on the tops of the four support towers, as well as five locations on the suspension cables; data were gathered at rates of 10 and 20 Hz. In addition, air and steel temperatures were gathered every 10 min. The GNSS data were processed in an On The Fly manner relative to a reference receiver located on a fixed position adjacent to the Bridge, and the resulting dataset was compared to the air and steel temperature data measurements, and correlations reported. Moving average filters that eliminate short-term movements due to wind loading and traffic loading were applied to the GNSS data, resulting in the longer-term deflections due to temperature changes every 10 min. The temperature over the 3 days varied by up to 10 °C, and movements of the order of decimetres were seen. Clear numerical correlations between the changes in temperature and the changes in height are presented when analysed at these 10-min intervals, suggesting that temperature compensation in structural health monitoring systems could be readily applied, resulting in a sustainable structure

Renormalon Singularities of the QCD Vacuum Polarization Function to Leading Order in 1/Nf1/N_{f}

We explicitly determine the residues and orders of all the ultra-violet (UV) and infra-red (IR) renormalon poles in the Borel plane for the QCD vacuum polarization function (Adler D-function), to leading order in an expansion in the number of quark flavours, $N_{f}$. The singularity structure is precisely as anticipated on general grounds. In particular, the leading IR renormalon is absent, in agreement with operator product expansion ideas. There is a curious and unexplained symmetry between the third and higher UV and IR renormalon residues. We are able to sum up separately UV and IR contributions to obtain closed form results involving $\zeta$-functions. We argue that the leading UV renormalon should have a more complicated structure than conventionally assumed. The disappearance of IR renormalons in flavour-saturated SU($N$) QCD is shown to occur for $N=3,6$ or 9.Comment: 22 pages of LaTeX, revisions to this paper are mainly typographica

Quantum inequalities in two dimensional curved spacetimes

We generalize a result of Vollick constraining the possible behaviors of the renormalized expected stress-energy tensor of a free massless scalar field in two dimensional spacetimes that are globally conformal to Minkowski spacetime. Vollick derived a lower bound for the energy density measured by a static observer in a static spacetime, averaged with respect to the observers proper time by integrating against a smearing function. Here we extend the result to arbitrary curves in non-static spacetimes. The proof, like Vollick's proof, is based on conformal transformations and the use of our earlier optimal bound in flat Minkowski spacetime. The existence of such a quantum inequality was previously established by Fewster.Comment: revtex 4, 5 pages, no figures, submitted to Phys. Rev. D. Minor correction