Examining Links between Social Anxiety and Relational Aggression in Adolescence: The Influence of Rumination and Anger

Social anxiety is linked to more covert forms of aggressive behavior, particularly reactive and relational aggression in early adolescent and young adult samples. Adolescents with social anxiety and those who engage in reactive relational aggression are also more likely to have difficulties regulating emotions (e.g., anger) and show maladaptive cognitive coping styles (e.g., rumination). The goal of the present study was to assess the relationship between social anxiety and reactive relational aggression in adolescents (14-17 years), combining the form and function of aggression, and to examine trait anger and anger rumination as underlying factors that may explain the relationship between social anxiety and reactive relational aggression. The current study hypothesized that adolescents with social anxiety would engage in reactive relational aggression through the use of anger rumination, and this relationship would only be present in adolescents with higher levels of trait anger. High school adolescents in grades 9 to 12 (N=105; Mage = 15.43; 61% female) were recruited through their local school and community to complete a 30-minute, battery of questionnaires examining social anxiety, trait anger, anger rumination, and reactive relational aggression. Adolescents completed questionnaires anonymously via an online survey platform, Qualtrics, and were subsequently compensated for their time. Results supported study hypotheses. Simple regression analyses found that social anxiety was positively related to trait anger, anger rumination and reactive relational aggression. Trait anger and anger rumination were also positively correlated with reactive relational aggression. A conditional process analysis was conducted to test the major study hypothesis. Adolescents with social anxiety were more likely to engage in reactive relational aggression if they ruminated about experiences that created anger, and this relationship was present in adolescents with higher levels of trait anger. Gender differences were also explored. Higher rates of social anxiety and anger rumination were found in females. No other gender differences were found. Overall, socially anxious adolescents showed a greater tendency to engage in reactive relational aggression adding to the current literature. Difficulties regulating negative emotions, like anger, and ineffective cognitive coping strategies, such as anger rumination, were precipitating factors that likely maintained socially anxious and aggressive behaviors

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+T cell dysregulation and accumulation

The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co -exist-ing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8+ T cell clonal expansions and autoimmunity, we analyzed patients and mice with germline STAT3 GOF mutations. STAT3 GOF mutations drove the accumulation of effector CD8+ T cell clones highly expressing NKG2D, the receptor for stress-induced MHC-class-I-related molecules. This subset also expressed genes for granzymes, perforin, interferon-y, and Ccl5/Rantes and required NKG2D and the IL-15/IL-2 receptor IL2RB for maximal accumula-tion. Leukocyte-restricted STAT3 GOF was sufficient and CD8+ T cells were essential for lethal pathology in mice. These results demonstrate that STAT3 GOF mutations cause effector CD8+ T cell oligoclonal accumu-lation and that these rogue cells contribute to autoimmune pathology, supporting the hypothesis that somatic mutations in leukemia/lymphoma driver genes contribute to autoimmune disease.Peer reviewe

Infection after medical abortion: a review of the literature.

Medical abortion regimens have become widely used, but the frequency of infection after medical abortion is not well documented. This systematic review provides data on infectious complications after medical abortion. We searched Medline for articles written before July 2003 to determine the frequency of infection after medical abortion up to 26 weeks of gestation. We reviewed all articles and extracted data on the frequency of infection from 65 studies. The frequency of diagnosed and/or treated infection after medical abortion was very low (0.92%, N = 46,421) and varied among regimens. Results of this review confirm that, with respect to infectious complications, medical abortion is a safe and effective option for first- and second-trimester pregnancy termination. After accounting for regional variations in diagnosis, there is little difference in frequency of infection among the regimens reviewed. Future studies should report clear diagnosis and treatment standards for infection so that more precise information becomes available

Ectopic pregnancy and medical abortion.

OBJECTIVE: Medical abortion regimens have become more widely used to terminate early pregnancies. Medical abortion providers are concerned to diagnose and exclude women with ectopic pregnancy before initiating treatment, as with any early pregnancy termination. Yet, there is little information about whether the various pretreatment screening methods used are adequate. We reviewed published literature to determine the overall success of screening for ectopic pregnancy before medical abortion treatment. DATA SOURCES: We searched MEDLINE for articles on medical abortion regimens published before July 2003. METHODS OF STUDY SELECTION: We selected English language articles of studies of medical abortion with sample sizes greater than 100, which reported on ectopic pregnancy diagnosed after medical abortion treatment. Fifty-seven of 85 prospective studies and randomized trials (69%) met these inclusion criteria. We also included data from 2 unpublished studies because they were large and well-controlled and because they included serious adverse events known to us, which we did not deem fair to exclude from our analysis. TABULATION, INTEGRATION, AND RESULTS: Each article was reviewed by one author. Data from selected studies were compiled, and the frequency of ectopic pregnancy diagnosed after medical abortion treatment was calculated. Ectopic pregnancy was diagnosed very infrequently following medical abortion procedures, occurring in only 10 of 44,789 (0.02%) women. CONCLUSION: The very low frequency of ectopic pregnancies diagnosed after medical abortion treatment demonstrates that the various pretreatment screening methods that providers use to exclude patients with ectopic pregnancies are successful. Further, there is no evidence to suggest that medical abortion treatment leads to unusual complications for women with ectopic pregnancies

Social complexity as a proximate and ultimate factor in communicative complexity

The ‘social complexity hypothesis’ for communication posits that groups with complex social systems require more complex communicative systems to regulate interactions and relations among group members. Complex social systems, compared with simple social systems, are those in which individuals frequently interact in many different contexts with many different individuals, and often repeatedly interact with many of the same individuals in networks over time. Complex communicative systems, compared with simple communicative systems, are those that contain a large number of structurally and functionally distinct elements or possess a high amount of bits of information. Here, we describe some of the historical arguments that led to the social complexity hypothesis, and review evidence in support of the hypothesis. We discuss social complexity as a driver of communication and possible causal factor in human language origins. Finally, we discuss some of the key current limitations to the social complexity hypothesis—the lack of tests against alternative hypotheses for communicative complexity and evidence corroborating the hypothesis from modalities other than the vocal signalling channel