Stranded superconducting cable of improved design

High-current cable developed in liquid helium cooled magnets uses aluminum wire interspersed with the superconductor strands. The aluminum maintains higher electrical conductivity, is light in weight, and has low thermal capacity

The meteorology of Mars and Venus Final report

Meteorology of Mars and Venu

The southern dust pillars of the Carina Nebula

We present preliminary results from a detailed study towards four previously detected bright mid-infrared sources in the southern part of the Carina Nebula: G287.73--0.92, G287.84--0.82, G287.93--0.99 and G288.07--0.80. All of these sources are located at the heads of giant dust pillars that point towards the nearby massive star cluster, Trumpler 16. It is unclear if these pillars are the prime sites for a new generation of triggered star formation or if instead they are the only remaining parts of the nebula where ongoing star fromation can take place.Comment: 2 pages, to appear in the proceedings of "Hot Star Workshop III: The Earliest Phases of Massive Star Birth" (ed. P.A. Crowther

Empirical Investigation of Flexible Pricing and Payment Alternatives on Canadian Wheat Board Pooling for Wheat

Crop Production/Industries, Marketing,

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown. METHODS AND RESULTS: With the use of computer molecular modeling, we discovered that C242T single-nucleotide polymorphism causes significant structural changes in the extracellular loop of p22(phox) and reduces its interaction stability with Nox2 subunit. Gene transfection of human pulmonary microvascular endothelial cells showed that C242T p22(phox) significantly reduced Nox2 expression but had no significant effect on basal endothelial O2 (.-) production or the expression of Nox1 and Nox4. When cells were stimulated with tumor necrosis factor-α (or high glucose), C242T p22(phox) significantly inhibited tumor necrosis factor-α-induced Nox2 maturation, O2 (.-) production, mitogen-activated protein kinases and nuclear factor κB activation, and inflammation (all P<0.05). These C242T effects were further confirmed using p22(phox) short-hairpin RNA-engineered HeLa cells and Nox2(-/-) coronary microvascular endothelial cells. Clinical significance was investigated by using saphenous vein segments from non-coronary heart disease subjects after phlebotomies. TT (C242T) allele was common (prevalence of ≈22%) and, in comparison with CC, veins bearing TT allele had significantly lower levels of Nox2 expression and O2 (.-) generation in response to high-glucose challenge. CONCLUSIONS: C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 activation and oxidative response to tumor necrosis factor-α or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases

Topology, Quantum Gravity and Particle Physics

It is argued that quantum gravity has an interpretation as a topological field theory provided a certain constraint from the path intergral measure is respected. The constraint forces us to couple gauge and matter fields to gravity for space - time dimensions different from 3. We then discuss possible models which may be relevant to our universe.Comment: 18 pages, LaTeX. Replaced version corrects typos and has additional reference

GEOS I tracking station positions on the SAO standard earth /C-5/

GEOS 1 tracking station positions on SAO standard earth C-5 mode