MOD-0 wind turbine dynamics test correlations

The behavior of the teetered, downwind, free yaw, MOD-0 wind turbine, as represented by NASA dynamic test data, was used to support confidence in the Hamilton Standard computer code simulations. Trim position, performance at trim, and teeter response as predicted by the computer codes were compared to test results. Using the computer codes, other possible configurations for MOD-0 were investigated. Several new test configurations are recommended for exploring free yaw behavior. It is shown that eliminating rotor tilt and optimizing cooling and blade twist can contribute to good free yaw behavior and stability. The effects of rotor teeter, teeter gravity balance, inflow and other physical and operating parameters were also investigated

Advanced turbo-prop airplane interior noise reduction-source definition

Acoustic pressure amplitudes and phases were measured in model scale on the surface of a rigid semicylinder mounted in an acoustically treated wind tunnel near a prop-fan (an advanced turboprop with many swept blades) model. Operating conditions during the test simulated those of a prop-fan at 0.8 Mach number cruise. Acoustic pressure amplitude and phase contours were defined on the semicylinder surface. Measurements obtained without the semi-cylinder in place were used to establish the magnitude of pressure doubling for an aircraft fuselage located near a prop-fan. Pressure doubling effects were found to be 6dB at 90 deg incidence decreasing to no effect at grazing incidence. Comparisons of measurements with predictions made using a recently developed prop-fan noise prediction theory which includes linear and non-linear source terms showed good agreement in phase and in peak noise amplitude. Predictions of noise amplitude and phase contours, including pressure doubling effects derived from test, are included for a full scale prop-fan installation

Dynamic response and stability of a composite prop-fan model

Results are presented for blade response and stability during wind tunnel tests of a 62.2 cm diameter model of a prop-fan, advanced turboprop, with swept graphite/epoxy composite blades. Measurements of dynamic response were made with the rotor mounted on an isolated nacelle, with varying tilt for nonuniform inflow, at flow speeds from 0.36 to 0.9 Mach number. The blade displayed no instabilities over the operating range tested, up to 0.9 Mach number and 10,000 RPM. Measurements are compared with those for other prop-fan models of both solid metal and graphite composite construction. The swept composite blade had less response than an unswept composite blade. Composite blades had more response than metal blades. Measurements are compared with theoretically based predictions. The 1-P blade response was significantly overpredicted using unimproved methods and somewhat overpredicted using improved methods. Unexpectedly high 2-P strain levels were measured and suggest the presence of nonlinear effects on blade response

The Role of Cold Flows in the Assembly of Galaxy Disks

We use high resolution cosmological hydrodynamical simulations to demonstrate that cold flow gas accretion, particularly along filaments, modifies the standard picture of gas accretion and cooling onto galaxy disks. In the standard picture, all gas is initially heated to the virial temperature of the galaxy as it enters the virial radius. Low mass galaxies are instead dominated by accretion of gas that stays well below the virial temperature, and even when a hot halo is able to develop in more massive galaxies there exist dense filaments that penetrate inside of the virial radius and deliver cold gas to the central galaxy. For galaxies up to ~L*, this cold accretion gas is responsible for the star formation in the disk at all times to the present. Even for galaxies at higher masses, cold flows dominate the growth of the disk at early times. Within this modified picture, galaxies are able to accrete a large mass of cold gas, with lower initial gas temperatures leading to shorter cooling times to reach the disk. Although star formation in the disk is mitigated by supernovae feedback, the short cooling times allow for the growth of stellar disks at higher redshifts than predicted by the standard model.Comment: accepted to Ap

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown. METHODS AND RESULTS: With the use of computer molecular modeling, we discovered that C242T single-nucleotide polymorphism causes significant structural changes in the extracellular loop of p22(phox) and reduces its interaction stability with Nox2 subunit. Gene transfection of human pulmonary microvascular endothelial cells showed that C242T p22(phox) significantly reduced Nox2 expression but had no significant effect on basal endothelial O2 (.-) production or the expression of Nox1 and Nox4. When cells were stimulated with tumor necrosis factor-α (or high glucose), C242T p22(phox) significantly inhibited tumor necrosis factor-α-induced Nox2 maturation, O2 (.-) production, mitogen-activated protein kinases and nuclear factor κB activation, and inflammation (all P<0.05). These C242T effects were further confirmed using p22(phox) short-hairpin RNA-engineered HeLa cells and Nox2(-/-) coronary microvascular endothelial cells. Clinical significance was investigated by using saphenous vein segments from non-coronary heart disease subjects after phlebotomies. TT (C242T) allele was common (prevalence of ≈22%) and, in comparison with CC, veins bearing TT allele had significantly lower levels of Nox2 expression and O2 (.-) generation in response to high-glucose challenge. CONCLUSIONS: C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 activation and oxidative response to tumor necrosis factor-α or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases

Induced topological pressure for countable state Markov shifts

We introduce the notion of induced topological pressure for countable state Markov shifts with respect to a non-negative scaling function and an arbitrary subset of finite words. Firstly, the scaling function allows a direct access to important thermodynamical quantities, which are usually given only implicitly by certain identities involving the classically defined pressure. In this context we generalise Savchenko's definition of entropy for special flows to a corresponding notion of topological pressure and show that this new notion coincides with the induced pressure for a large class of H\"older continuous height functions not necessarily bounded away from zero. Secondly, the dependence on the subset of words gives rise to interesting new results connecting the Gurevi{\vc} and the classical pressure with exhausting principles for a large class of Markov shifts. In this context we consider dynamical group extentions to demonstrate that our new approach provides a useful tool to characterise amenability of the underlying group structure.Comment: 28 page

Separation of biological materials in microgravity

Partition in aqueous two phase polymer systems is a potentially useful procedure in downstream processing of both molecular and particulate biomaterials. The potential efficiency of the process for particle and cell isolations is much higher than the useful levels already achieved. Space provides a unique environment in which to test the hypothesis that convection and settling phenomena degrade the performance of the partition process. The initial space experiment in a series of tests of this hypothesis is described