49 research outputs found
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells
Peer reviewedPublisher PD
Measurement of the Proton Spin Structure Function g1p with a Pure Hydrogen Target
A measurement of the proton spin structure function g1p(x,Q^2) in
deep-inelastic scattering is presented. The data were taken with the 27.6 GeV
longitudinally polarised positron beam at HERA incident on a longitudinally
polarised pure hydrogen gas target internal to the storage ring. The kinematic
range is 0.021<x<0.85 and 0.8 GeV^2<Q^2<20 GeV^2. The integral
Int_{0.021}^{0.85} g1p(x)dx evaluated at Q0^2 of 2.5 GeV^2 is
0.122+/-0.003(stat.)+/-0.010(syst.).Comment: 7 pages, 3 figures, 1 table, RevTeX late
Beam-Induced Nuclear Depolarisation in a Gaseous Polarised Hydrogen Target
Spin-polarised atomic hydrogen is used as a gaseous polarised proton target
in high energy and nuclear physics experiments operating with internal beams in
storage rings. When such beams are intense and bunched, this type of target can
be depolarised by a resonant interaction with the transient magnetic field
generated by the beam bunches. This effect has been studied with the HERA
positron beam in the HERMES experiment at DESY. Resonances have been observed
and a simple analytic model has been used to explain their shape and position.
Operating conditions for the experiment have been found where there is no
significant target depolarisation due to this effect.Comment: REVTEX, 6 pages, 5 figure
Observation of a Coherence Length Effect in Exclusive Rho^0 Electroproduction
Exclusive incoherent electroproduction of the rho^0(770) meson from 1H, 2H,
3He, and 14N targets has been studied by the HERMES experiment at squared
four-momentum transfer Q**2>0.4 GeV**2 and positron energy loss nu from 9 to 20
GeV. The ratio of the 14N to 1H cross sections per nucleon, known as the
nuclear transparency, was found to decrease with increasing coherence length of
quark-antiquark fluctuations of the virtual photon. The data provide clear
evidence of the interaction of the quark- antiquark fluctuations with the
nuclear medium.Comment: RevTeX, 5 pages, 3 figure
The Flavor Asymmetry of the Light Quark Sea from Semi-inclusive Deep-inelastic Scattering
The flavor asymmetry of the light quark sea of the nucleon is determined in
the kinematic range 0.02<x<0.3 and 1 GeV^2<Q^2<10 GeV^2, for the first time
from semi-inclusive deep-inelastic scattering. The quantity
(dbar(x)-ubar(x))/(u(x)-d(x)) is derived from a relationship between the yields
of positive and negative pions from unpolarized hydrogen and deuterium targets.
The flavor asymmetry dbar-ubar is found to be non-zero and x dependent, showing
an excess of dbar over ubar quarks in the proton.Comment: 7 Pages, 2 figures, RevTeX format; slight revision in text, small
change in extraction of dbar-ubar and comparison with a high q2
parameterizatio
Three-dimensional photographic analysis of the face in European adults from southern Spain with normal occlusion: reference anthropometric measurements
Background: Recent non-invasive 3D photography method has been applied to facial analysis, offering numerous
advantages in orthodontic. The purpose of this study was to analyze the faces of a sample of healthy European
adults from southern Spain with normal occlusion in order to establish reference facial soft tissue anthropometric
parameters in this specific geographic-ethnic population, as well as to analyze sexual dimorphism.
Methods: A sample of 100 healthy adult volunteers consisting of 50 women (mean age, 22.92 ± 1.56 years) and 50
men (mean age, 22.37 ± 2.12 years) were enrolled in this study. All participants had normal occlusion, skeletal Class I,
mesofacial pattern, and healthy body mass index. Three-dimensional photographs of the faces were captured noninvasively
using Planmeca ProMax 3D ProFace®. Thirty landmarks related to the face, eyes, nose, and orolabial and chin
areas were identified.
Results: Male displayed higher values in all vertical and transversal dimensions, with the exception of the lower lip
height. Larger differences between sexes were observed in face, mandible, and nose. Male also had higher values in
the angular measurements which referred to the nose. No sex differences were found in transverse upper lip
prominence or transverse mandibular prominence. No differences were found in the ratio measurements, with the
exception of intercantal width/nasal width, which was higher in women than in men.
Conclusions: Reference anthropometric measurements of facial soft tissues have been established in European
adults from southern Spain with normal occlusion. Significant sexual dimorphism was found, with remarkable
differences in size between sexe
Observation of a Single-Spin Azimuthal Asymmetry in Semi-Inclusive Pion Electro-Production
Single-spin asymmetries for semi-inclusive pion production in deep-inelastic
scattering have been measured for the first time. A significant target-spin
asymmetry of the distribution in the azimuthal angle phi of the pion relative
to the lepton scattering plane was observed for pi+ electro-production on a
longitudinally polarized hydrogen target. The corresponding analyzing power in
the sin(phi) moment of the cross section is 0.022 +/- 0.005 +/- 0.003. This
result can be interpreted as the effect of terms in the cross section involving
chiral-odd spin distribution functions in combination with a time-reversal-odd
fragmentation function that is sensitive to the transverse polarization of the
fragmenting quark.Comment: 5 pages of RevTex, 3 ps figures, 2 table
Flavor Decomposition of the Polarized Quark Distributions in the Nucleon from Inclusive and Semi-inclusive Deep-inelastic Scattering
Spin asymmetries of semi-inclusive cross sections for the production of
positively and negatively charged hadrons have been measured in deep-inelastic
scattering of polarized positrons on polarized hydrogen and 3He targets, in the
kinematic range 0.023<x<0.6 and 1 GeV^2<Q^2<10 GeV^2. Polarized quark
distributions are extracted as a function of x for up $(u+u_bar) and down
(d+d_bar) flavors. The up quark polarization is positive and the down quark
polarization is negative in the measured range. The polarization of the sea is
compatible with zero. The first moments of the polarized quark distributions
are presented. The isospin non-singlet combination Delta_q_3 is consistent with
the prediction based on the Bjorken sum rule. The moments of the polarized
quark distributions are compared to predictions based on SU(3)_f flavor
symmetry and to a prediction from lattice QCD.Comment: 14 pages, 6 figures (eps format), 10 tables in Latex New version
contains tables of asymmetries and correlation matri
Desarrollo, subjetividad y transgresiones identitarias en las costas del sur- austral chileno
This work is part of an investigation into the contemporary dynamics of development and modernization in the southern and far southern coastal areas of Chile, specifically the shoreline of the northern part of the Aysen Region. The objective is to propose a theoretical-conceptual reflection to enable ethnographic data to be framed as a problem and interpreted as a function of a political reading which - why not say so? - could transform the world of the southern and far southern coastal zone. The central argument of the text is hypothetical: the dilemmas of development, in the current circumstances of the coasts of the Aysen Region, are susceptible of resolution (at least up to a point) from a conscious, reflexive change of perspective on culture as the word is understood in anthropology. Este trabajo se enmarca en una investigación sobre las dinámicas contemporáneas del desarrollo y la modernización en las costas sur-australes de Chile, específicamente en el litoral norte de la región de Aisén. A partir de un conjunto de datos etnográficos se propone una reflexión teórico-conceptual que permita problematizar e interpretar esos datos en función de una lectura política y, por qué no decirlo, transformadora del mundo costero sur-austral. El argumento central del texto tiene carácter hipotético: las encrucijadas del desarrollo, en las actuales coyunturas de las costas aiseninas, son susceptibles de ser resueltas (al menos hasta cierto punto) a partir de un giro reflexivo y consciente sobre eso que en antropología llamamos cultura
Albumin-Associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal
BACKGROUND: Although human embryonic stem cells (hESCs) hold great promise as a source of differentiated cells to treat several human diseases, many obstacles still need to be surmounted before this can become a reality. First among these, a robust chemically-defined system to expand hESCs in culture is still unavailable despite recent advances in the understanding of factors controlling hESC self-renewal. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we attempted to find new molecules that stimulate long term hESC self-renewal. In order to do this, we started from the observation that a commercially available serum replacement product has a strong positive effect on the expansion of undifferentiated hESCs when added to a previously reported chemically-defined medium. Subsequent experiments demonstrated that the active ingredient within the serum replacement is lipid-rich albumin. Furthermore, we show that this activity is trypsin-resistant, strongly suggesting that lipids and not albumin are responsible for the effect. Consistent with this, lipid-poor albumin shows no detectable activity. Finally, we identified the major lipids bound to the lipid-rich albumin and tested several lipid candidates for the effect. CONCLUSIONS/SIGNIFICANCE: Our discovery of the role played by albumin-associated lipids in stimulating hESC self-renewal constitutes a significant advance in the knowledge of how hESC pluripotency is maintained by extracellular factors and has important applications in the development of increasingly chemically defined hESC culture systems