6 research outputs found
Joint analysis of phenotypic and molecular diversity provides new insights on the genetic variability of the brazilian physic nut germplasm bank
- Author
- Alexandre Alonso Alves
- Asante IK
- Berchmans HJ
- Bhering LL
- Bhering LL
- Bosetti F
- Brondani RPV
- Bruno GalvĂŞas Laviola
- Collard BCY
- Colombo C
- Cosme DamiĂŁo Cruz
- Cruz CD
- Cruz CD
- Dias LAS
- Divakara BN
- Drumond MA
- DurĂŁes FMO
- Eduardo Fernandes Formighieri
- Ginwal HS
- Gower JC
- Grattapaglia D
- Gurgel FD
- Hamza H
- Jaccard P
- Koehler-Santos P
- Kumar RV
- Laviola BG
- Laviola BG
- Laviola BG
- Leonardo Lopes Bhering
- Lewontin RC
- Manly BFJ
- Martins FA
- Modi MK
- Nybom H
- Pamidimarri DVNS
- Ram SG
- Reed DH
- Reis AMM
- Rocha RB
- Rosado TB
- Sestili S
- Silva-Junior OB
- Subramanyam K
- Sun QB
- Sunil N
- Tatiana Barbosa Rosado
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Origin, evolution and genome distribution of microsatellites
- Author
- Amos W
- Arcot SS
- Avise J
- Bachtrog D
- Bailey AD
- Balloux F
- Balloux F
- Balloux F
- Belkum A Van
- Bernardo R
- Bichara M
- Biggin MD
- Blouin MS
- Bowen BW
- Bowers J
- Brondani RV
- Chakraborty R
- Chakraborty R
- Ciampi AY
- Cipriani G
- Collevatti RG
- Collevatti RG
- Cooper G
- Cregan B
- Crollius HR
- Crow J
- Cummings CJ
- Dayanandan S
- Di Rienzo A
- Di Rienzo A
- Donnelly MJ
- Dow BD
- Dow BD
- Eder Jorge Oliveira
- Ellegren H
- Estoup A
- Estoup A
- Everett CM
- Falconer DS
- Field D
- Foster L
- Gaggiotti OE
- Garner TWJ
- Gilmour DS
- Goldstein DB
- Hancock JM
- Hedrick W
- Hentschel CC
- Heywood VH
- Hood DW
- Hunter BR
- Isagi Y
- Jackson PJ
- Jarne P
- Juliano Gomes Pádua
- Kalinowski ST
- Kashi Y
- Kempthorne O
- Knapik EW
- Kolodner RD
- Kruglyak S
- Lemes MR
- Levinson G
- Lin X
- Lowenhaupt K
- Lynch M
- Mahadevan M
- Malécot G
- Maria Imaculada Zucchi
- Maria LĂşcia Carneiro Vieira
- Messier W
- Metzgar M
- Morgante M
- Morin PA
- Moxon R
- MĂ©tais I
- Nadir E
- Nei M
- Nichols RA
- Novick RR
- O’Donnell KH
- O’Donnell WT
- Pardue ML
- Petit RJ
- Pinto LR
- Pinto LR
- Primmer CR
- Pupko T
- Queller DC
- Ramsay L
- Ritland K
- Roa AC
- Roland Vencovsky
- Rose O
- Rosenberg SM
- Rubinsztein DC
- Saunders NJ
- Schlotterer C
- Schlötterer C
- Schlötterer C
- Schlötterer C
- Sia EA
- Sia EA
- Slatkin M
- Song QJ
- Souza E
- Stallings RL
- Steinkellner H
- Strand M
- Streisinger G
- Thompson EA
- Treco D
- TĂłth G
- Vencovsky R
- Wahls W
- Weir BS
- White G
- Wilder J
- Williamson JE
- Wright JM
- Wright S
- Wright S
- Wright S
- Wright S
- Zhu Y
- Zucchi MI
- Zucchi MI
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2006
- Field of study
Physiological characterization of common bean (Phaseolus vulgaris L.) under abiotic stresses for breeding purposes
- Author
- AB Heinemann
- AC Lanna
- AJ Scott
- Alécio Souza Moreira
- Anna Cristina Lanna
- BN Sponchiado
- C Lesk
- CA Alvares
- Claudio Brondani
- Cleber M. GuimarĂŁes
- D Chen
- D Kahle
- DA Wilhite
- DC Nielsen
- DF Ferreira
- DW Lawlor
- E Bitocchi
- E Georgii
- EH Beck
- F Tardieu
- FP Carvalho
- G Shi
- Gesimária Ribeiro Costa Coelho
- GV Subbarao
- H Nakano
- H Omae
- H Omae
- HP Graham
- I Ahuja
- I Konsens
- IM Rao
- JA Acosta-Gallegos
- JA PolanĂa
- JA PolanĂa
- JI Bergonci
- João Antônio Mendonça
- KA Schneider
- M Ashraf
- M Bajji
- MA Rosales
- MF Mohamed
- N Petry
- P Ramirez-Vallejo
- Paula Arielle Mendes Ribeiro Valdisser
- PE McClean
- PF Scholander
- R Jin
- RA Fischer
- Renato Adolfo Silva
- Rosana Pereira Vianello
- RV Ribeiro
- RV Ribeiro
- S Li
- S Mahajan
- S Mamidi
- SE Beebe
- SE Beebe
- SM Cuéllar-Ortiz
- T Lawson
- Tatiana Maris Ferraresi
- VA Monterroso
- ZB Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Microsatellite marker development by partial sequencing of the sour passion fruit genome (Passiflora edulis Sims)
- Author
- A Untergasser
- AJC Viana
- AK Hansen
- Alexandre M Martins
- ALR Cazé
- Ana Maria Costa
- AP Dobson
- C Paiva
- CB Cerqueira-Silva
- CB Cerqueira-Silva
- CB Cerqueira-Silva
- CBM Cerqueira-Silva
- CBM Cerqueira-Silva
- CE Holleley
- D Csencsics
- D Fajardo
- D Paetkau
- DB Goldstein
- DC Ortiz
- DR Zerbino
- E Khurana
- EJ Oliveira
- EJ Oliveira
- F Ferreira
- F Rohlf
- FR Ferreira
- Fábio G Faleiro
- G Bellon
- G Evanno
- GAF Oliveira
- HA Penha
- J Abdelkrim
- J Doyle
- J MacDougal
- J Ocampo
- JG Padua
- JK Pritchard
- JK Pritchard
- JS RendĂłn
- KG Lim
- L Karagyozov
- L Salmela
- L Zhai
- LF Santos
- LMM Meletti
- M Litt
- M Lynch
- M Matschiner
- M Morgante
- ML Crochemore
- ML Crochemore
- MM Souza
- Márcio E Ferreira
- N Fonseca-Trujillo
- N Myers
- Nilton T V Junqueira
- NO Domaniç
- PI Silva
- R d O Plotze
- R GuigĂł
- R Li
- RPV Brondani
- RR Rodrigues
- RV Reis
- S d PM Abreu
- S Segura
- Susan Araya
- TA Castoe
- TC Marshall
- VC Muschner
- W Powell
- ZQ Ma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diversity array technology (DArT)-based mapping of phenotypic variations among recombinant inbred lines of WAB638-1/PRIMAVERA under drought stress
- Author
- A Diagne
- A Diagne
- A Dubock
- A Fiust
- A Shahin
- B Myśków
- B Yue
- BP Swamy
- BS Thorat
- C Brondani
- C Li
- C Lu
- C Saintenac
- C Sansaloni
- C Zhu
- CF Lu
- D Xue
- DA Cartwright
- DH Beighley
- DW Chen
- E Chancerel
- ED Purbajanti
- GH Zhang
- H Cui
- H Li
- HJ Schouten
- J Bernier
- J Cairns
- J Hu
- J Simmonds
- J Solis
- JC Lanceras
- JH Xiao
- K Cui
- K Ishimaru
- K Kaladhar
- K Kazan
- K Semagn
- K Suenaga
- KA Adeboye
- KA Adeboye
- L Lei
- L Meng
- L Yang
- LA Egea
- LL Ma
- M Cooper
- M Islam
- M Maheswaran
- M Wójcik-Jagła
- MC Champoux
- N Sandhu
- P Lewis
- P Moncada
- P Qu
- P Vikram
- P Wang
- PR Marri
- Q Xu
- QH Yang
- R Marino
- R Ren
- R Venuprasad
- R Venuprasad
- RV Kesseli
- S Ambawat
- S Fukai
- S Hittalmani
- S Teng
- SK Truong
- SR Barik
- T Sasaki
- TB De Leon
- TFC Mackay
- V Ravindra-Babu
- W Hussain
- X Wang
- Y Harushima
- ZK Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- AraĂşjo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
- Ausperger KM
- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
- Ayasse D
- Ayau Milla O
- Ayesu K
- Aylward P
- Azhdari M
- Azua MG
- Babbar A
- Babbolin M
- Babilonia N
- Babilonia N
- Babu P
- Babu R
- Babuty D
- Badenhorst J
- Badila E
- Bae HJ
- Bagatin J
- Bagby J
- Bai F
- Baine S
- Bakliza Z
- Balboa W
- Baldwin E
- Ball E
- Ballyuzek M
- Baman R
- Bamhorst M
- Bamrungpong P
- Banaeian F
- Banikova A
- Banikova A
- Banker D
- Bansal N
- Banville P
- Bar M
- Barai A
- Baranyai M
- Barash B
- Barbarash O
- Barber M
- Barbera S
- Barcinas R
- Barker T
- Barnhorst M
- Barquero R
- Barrington P
- Barros R
- Barroso D
- Bart B
- Bartholomaus D
- Bartkowiak A
- Bartos D
- Bashkireva A
- Basson M
- Baszak J
- Baszak J
- Batchell K
- Batista M
- Batta C
- Battistelli E
- Batushkin V
- Bauch F
- Bauch F
- Bauer K
- Bautista C
- Bayata S
- Bayata S
- Baylacher M
- Bayram Llamas E
- Bazylevych A
- Beasley R
- Beck P
- Bedenko E
- Bedoya R
- Bedregal SA
- Bedwell N
- Beerts C
- Beeton I
- Behm K
- Beinart S
- Bekal S
- Belatsky V
- Belcuore M
- Belenky D
- Belhassane A
- Beloscar J
- Belousova L
- Ben Ari M
- Benatar J
- Bengtsson AS
- Bengus C
- Benicka E
- Benjarge P
- Bensimhon D
- Bentivenga L
- Benton J
- Berbari H
- Berbari H
- Bereznyakov I
- Berger CJ
- Berger N
- Bergovec M
- Bergovec M
- Berk M
- Berka L
- Berli M
- Berli M
- Bernard J
- Bernhardt P
- Berni A
- Berns S
- Berrouschot J
- Bertolim Precoma D
- Betcher J
- Beyer-Westendorf J
- Bharani A
- Bhargava R
- Bhargava V
- Bhaskarwar P
- Bhuti M
- Bianchini M
- Bilal B
- Bilazarian S
- Bingham S
- Biniek D
- Biniwale A
- Binns M
- Biscardi R
- Bjelobrk M
- Blagden M
- Blanc J
- Blanc JJ
- Blanco Coronado J
- Blihar O
- Block T
- Blom KB
- Blomström P
- Blonder R
- Bloomberg K
- Bloomberg R
- Blue B
- Bobade M
- Bobbie C
- Bobescu E
- Bocanera M
- Bognar A
- Bojanowska E
- Bokarev I
- Bollova D
- Bolohan F
- Bolohan F
- Bolton R
- Bonds C
- Bonin K
- Bonora M
- Boriani G
- Borowski W
- Borsheim M
- Borthwick L
- Bosco B
- Bose S
- Bossaers J
- Botelho R
- Botero R
- Botha L
- Bouchard A
- Bourlios P
- Boursin P
- Bouzo M
- Bowden W
- Bowen L
- Bowman B
- Boyer M
- Bozek B
- Bradley A
- Braemer U
- Braun D
- Braun R
- Braunwald E
- Braunwald E
- Breschi M
- Bridge C
- Brilakis E
- Briscoe C
- Broberg M
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- Bronisz M
- Brown F
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- Browning J
- Brtko M
- Brtko M
- Brubaker S
- Bruguera Cortada J
- Bruning T
- Bruton T
- Buchholz M
- Budassi N
- Buelow-Johansen B
- Bugueño C
- Buhler A
- Buhr M
- Buiks C
- Buiks C
- Builes A
- Buksa B
- Bulgari M
- Bulygin S
- Burianova H
- Burianova H
- Bush D
- Bustamante G
- Bustamante Labarta G
- Busz-Papiez B
- Butcher S
- Buza V
- Buzzetti C
- Bybee K
- Cabero P
- Cabrera J
- Caccavo A
- Caceres M
- Cader C
- Cajulis C
- Cakmak N
- Calambur N
- Calderon M
- Calik A
- Calvo C
- Calvo G
- Calvo M
- Calvo Vargas C
- Camm J
- Camm J
- Cammell R
- Campbell G
- Campisto Y
- Canaday D
- Cannoni S
- Cano N
- Canosa R
- Capasso-Gulve E
- Capiau L
- Caplan J
- Car S
- Cardona Muñoz E
- Cardoza T
- Carevic V
- Carey G
- Carey J
- Carlsson T
- Carne M
- Carr K
- Carraro A
- Carrasco GT
- Carrillo J
- Carrion A
- Carroll L
- Cartasegna L
- Caruso O
- Casares E
- Casas R
- Castro C
- Caterini T
- Cavanna L
- Cayli M
- Cayli M
- Ceirano C
- Celic V
- Cemerlic Adjic N
- Cendali G
- Cermak O
- Cermak O
- Cervellione K
- Cervi E
- Ceyhan C
- Ceyhan C
- Cha J
- Cha JK
- Cha MJ
- Chacon L
- Champagne M
- Chang M
- Chapman O
- Charlat M
- Chaturvedi S
- Chaves Junior H
- Chavez C
- Chehayeb R
- Chen JZ
- Chen SA
- Chen XP
- Chen YF
- Chen YP
- Chendey T
- Cheng CC
- Cheng CC
- Chernyavskaya T
- Cherrico M
- Chiang CE
- Chiang FT
- Chilvers M
- Chiou CW
- Chiu CZ
- Chmielowski A
- Cho BR
- Choi HH
- Choi KJ
- Choi Y
- Chompalova B
- Chopda M
- Choy A
- Christensen H
- Christensen L
- Christian T. Ruff
- Chumakova G
- Chun MY
- Chung A
- Chung N
- Chung WS
- Ciaramita J
- Cieslak B
- Ciezak P
- Ciglenecki N
- Ciobotaru G
- Ciortea M
- Clapp T
- Claussen H
- Clay A
- Cleveland D
- Clifton R
- Clinckemaille N
- Cobos D
- Cobos J
- Coching R
- Codutti O
- Cohen A
- Cohen A
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- Colin MA
- Colombo H
- Colquhoun D
- Coman I
- Comi G
- Concha M
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- Constance C
- Constantinescu M
- Constantinescu M
- Contzen C
- Cook S
- Coombs V
- Copley M
- Corbalan R
- Corbalán R
- Corbett B
- Corbut S
- Corchado D
- Correia J
- Correia J
- Cossu S
- Costache L
- Costantini C
- Costi P
- Cottiero R
- Coutinho E
- Coutu B
- Cowan L
- Cox C
- Coyle GS
- Cozma M
- Craft D
- Craig M
- Crerand W
- Creteanu M
- Crimmins D
- Cristaldi J
- Cristea M
- Crisu D
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- Cuneo C
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- Cury C
- Cush S
- Cymerman K
- Cymerman K
- Cásares Ramirez M
- D'Amico A
- D'Costa D
- D'Souza A
- Dabrowska M
- Dagan T
- Daitz C
- Dalby A
- Dalby A
- Dandekar U
- Dang N
- Daniels R
- Daniels S
- Dart A
- Daskalaki A
- Dastoli K
- Datta S
- Daut W
- Dave B
- Dave K
- Davicevic Z
- David D
- Davids M
- Davies D
- Davis A
- Davis C
- Davis C
- Davis S
- Davolos M
- Davuluri A
- Davé J
- de Arce Borda A
- De Bleecker J
- De Bruyne L
- De Caterina R
- de Groot J
- de Koning K
- de la Mora S
- De Lemos J
- de Melo RF
- De Pace D
- De Patta M
- De Servi S
- De Tollenaere M
- de Vos R
- de Vos R
- Dean J
- Debes C
- Decoulx E
- Deenadayalu N
- DeGarmo R
- Degtyareva E
- Delgadillo T
- Delgado A
- Delgado MD
- Delgado P
- Delgado Restrepo J
- Delgado S
- Demir H
- Demir H
- Demko A
- Denchev S
- Denie D
- Denis I
- Dennison K
- Deokar M
- Derlaga B
- Deruche E
- Derycker K
- Desai A
- Desai A
- DeSalle D
- Desfontaines P
- Desire A
- Despotovic N
- Dettmann S
- Devenport S
- Dewar C
- Dhar S
- Dharmarao A
- Di Lenarda A
- Di Niro M
- Di Pasquale G
- Dias P
- Diaz IA
- Diaz PA
- Diaz-Pintado M
- Dichristin U
- Dicker D
- Dickinson D
- Dickinson D
- DiCorcia L
- Dieckheuer U
- Diez Tejedor E
- DiGiovanna M
- Dimitra K
- Dinanian S
- Dioszeghy P
- Djokic I
- Djokovic A
- Djordjevic-Radojkovic D
- do Val R
- Dobre I
- Dobreanu D
- Doctor A
- Dodt K
- Doka B
- Domanska E
- Domingo D
- Donahue S
- Dong YG
- Dongas B
- Donova T
- Donovan D
- Dorn S
- Dorobantu M
- Dotani I
- Dotsenko S
- Dougal K
- Doughty R
- Douglas H
- Douglas S
- Dovgalevsky P
- Dovgan N
- Dowling C
- Dragomir D
- Dran R
- Drapchak I
- Drapkina O
- Drescher T
- Drew B
- Dreykluft K
- Dronov D
- Drozdiak R
- du Preez M
- Duda N
- Duff J
- Dufresne M
- Dugal J
- Duggal A
- Dukat A
- Duki Y
- Dulka T
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- Duncan D
- Dunn K
- Dunn S
- Duprat C
- Duris T
- Duris T
- Dutka C
- Dutra O
- Dutter S
- Dvoieglazova M
- Dzublik Y
- Dzupina A
- Dzupinova M
- Dzyak G
- Eade J
- Easton JD
- Ebano P
- Ebano P
- Ebert J
- Ebina E
- Ebreo N
- Edelstein J
- Eden M
- Edes I
- Edlund M
- Egorova L
- Egorova L
- Eikelboom J
- El Jarroudi F
- El Jarroudi F
- El Jarroudi M
- Elbl L
- Elbl L
- Eldadah Z
- Eldred R
- Elias M
- Elliott M. Antman
- Ellis G
- Ellis J
- Enad C
- Endo H
- Engdahl J
- Engelbrecht J
- Enger S
- Ensminger E
- Erasmus L
- Erceg P
- Erdogan D
- Erdogan D
- Erenrich N
- Erenrich N
- Eriksson G
- Ermis C
- Ermis C
- Erofeeva S
- Esip V
- Essop M
- Estol C
- Ettinger N
- Eugene Braunwald
- Everhart B
- Ewing B
- Exarchou E
- Ezekowitz M
- Facello A
- Facello M
- Faghih M
- Faghih M
- Fahmy R
- Faircloth C
- Falu E
- Fattore L
- Faucett S
- Faustino Saporito W
- Faynyk A
- Fedacko J
- Fedotov S
- Feil JF
- Fekete A
- Feld L
- Feldman J
- Felsman D
- Felten W
- Femenia F
- Feng C
- Fenu L
- Ferguson D
- Ferkl R
- Ferkl R
- Fernandez E
- Fernandez M
- Fernández Ruiz R
- Ferraz RF
- Ferreira L
- Ferri Certic J
- Fialkow J
- Filatov A
- Finimundi H
- Fink P
- Finkel M
- Finkelstein S
- Finlayson M
- Finsterbusch T
- Fiok J
- Fischell T
- Fishbein G
- Fisher M
- Fisher M
- Fisher M
- Fisher M
- Fisher R
- Fleck N
- Flecknoe-Brown S
- Fleets J
- Flint L
- Florenzano F
- Flores E
- Florian J
- Florian J
- Fonseca J
- Forck-Boedeker K
- Forgione C
- Forman S
- Formoso I
- Fortin C
- Foster B
- Fracaro V
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- Zamlynskyy M
- Zamorano JL
- Zanotti A
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- Zateyshchikov D
- Zateyshchikova A
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- Zharinov O
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- Zhukova N
- Zhurba S
- Zidkova E
- Zidkova E
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- Zielinski M
- Zienciuk-Krajka A
- Zimmermann EB
- Zimmermann S
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- Zondag M
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- Zubeeva G
- Zyatenkova E
- Ă…kerberg A
- Ă–stberg S
- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)