632 research outputs found
Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen
Polyomaviruses such as BK virus and JC virus have been linked to several diseases, but treatments that thwart their propagation are limited in part because of slow growth and cumbersome culturing conditions. In contrast, the replication of one member of this family, Simian Virus 40 (SV40), is robust and has been well-characterized. SV40 replication requires two domains within the viral-encoded large tumor antigen (TAg): The ATPase domain and the N-terminal J domain, which stimulates the ATPase activity of the Hsp70 chaperone. To assess whether inhibitors of polyomavirus replication could be identified, we examined a recently described library of small molecules, some of which inhibit chaperone function. One compound, MAL2-11B, inhibited both TAg's endogenous ATPase activity and the TAg-mediated activation of Hsp70. MAL2-11B also reduced SV40 propagation in plaque assays and compromised DNA replication in cell culture and in vitro. Furthermore, the compound significantly reduced the growth of BK virus in a human kidney cell line. These data indicate that pharmacological inhibition of TAg's chaperone and ATPase activities may provide a route to combat polyomavirus-mediated disease. © 2009 Elsevier B.V. All rights reserved
Strangeness in the nucleon and the ratio of proton-to-neutron neutrino-induced quasi-elastic yield
The electroweak form factors of the nucleon as obtained within a three flavor
pseudoscalar vector meson soliton model are employed to predict the ratio of
the proton and neutron yields from , which are induced by quasi-elastic
neutrino reactions. These predictions are found to vary only moderately in the
parameter space allowed by the model. The antineutrino flux of the up-coming
experiment determining this ratio was previously overestimated. The
corresponding correction is shown to have only a small effect on the predicted
ratio. However, it is found that the experimental result for the ratio
crucially depends on an accurate measurement of the energy of the knocked out
nucleon.Comment: 17 pages, LaTeX, 2 tables, 4 figures, Discussion on shape of strange
form factors added, Z. Phys. A, to be publishe
Extracting the Distribution Amplitudes of the rho meson from the Color Glass Condensate
We extract the leading twist-2 and subleading twist-3 Distribution Amplitudes
(DAs) of the rho meson using the HERA data on diffractive rho photoproduction.
We do so using several Colour Glass Condensate (CGC) inspired and a Regge
inspired dipole models. We find that our extracted twist-2 DA is not much model
dependent and is consistent with QCD Sum Rules and lattice predictions. The
extracted twist-3 DA is more model dependent but is still consistent with the
Sum Rules prediction.Comment: 21 pages, 10 figures, 3 tables. Section 6 revised, figures 8 and 9
and table 3 updated. Conclusions essentially unchange
Prompt atmospheric neutrino fluxes: perturbative QCD models and nuclear effects
We evaluate the prompt atmospheric neutrino flux at high energies using three
different frameworks for calculating the heavy quark production cross section
in QCD: NLO perturbative QCD, factorization including low-
resummation, and the dipole model including parton saturation. We use QCD
parameters, the value for the charm quark mass and the range for the
factorization and renormalization scales that provide the best description of
the total charm cross section measured at fixed target experiments, at RHIC and
at LHC. Using these parameters we calculate differential cross sections for
charm and bottom production and compare with the latest data on forward charm
meson production from LHCb at TeV and at TeV, finding good agreement
with the data. In addition, we investigate the role of nuclear shadowing by
including nuclear parton distribution functions (PDF) for the target air
nucleus using two different nuclear PDF schemes. Depending on the scheme used,
we find the reduction of the flux due to nuclear effects varies from to
at the highest energies. Finally, we compare our results with the
IceCube limit on the prompt neutrino flux, which is already providing valuable
information about some of the QCD models.Comment: 61 pages, 25 figures, 11 table
Baryon-Baryon Interactions
After a short survey of some topics of interest in the study of baryon-baryon
scattering, the recent Nijmegen energy dependent partial wave analysis (PWA) of
the nucleon-nucleon data is reviewed. In this PWA the energy range for both pp
and np is now 0 < Tlab < 350 MeV and a chi^2_{d.o.f.}=1.08 was reached. The
implications for the pion-nucleon coupling constants are discussed. Comments
are made with respect to recent discussions around this coupling constant in
the literature. In the second part, we briefly sketch the picture of the baryon
in several, more or less QCD-based, quark-models that have been rather
prominent in the literature. Inspired by these pictures we constructed a new
soft-core model for the nucleon-nucleon interaction and present the first
results of this model in a chi^2 -fit to the new multi-energy Nijmegen PWA.
With this new model we succeeded in narrowing the gap between theory and
experiment at low energies. For the energies Tlab = 25-320 MeV we reached a
record low chi^2_{p.d.p.} = 1.16. We finish the paper with some conclusions and
an outlook describing the extension of the new model to baryon-baryon
scattering.Comment: 12 pages LaTeX and one postscript figure included. Invited talk
presented at the XIVth European Conference of Few-Body Problems in Physics,
Amsterdam, August 23-28, 199
Long-Range Rapidity Correlations in Heavy Ion Collisions at Strong Coupling from AdS/CFT
We use AdS/CFT correspondence to study two-particle correlations in heavy ion
collisions at strong coupling. Modeling the colliding heavy ions by shock waves
on the gravity side, we observe that at early times after the collision there
are long-range rapidity correlations present in the two-point functions for the
glueball and the energy-momentum tensor operators. We estimate rapidity
correlations at later times by assuming that the evolution of the system is
governed by ideal Bjorken hydrodynamics, and find that glueball correlations in
this state are suppressed at large rapidity intervals, suggesting that
late-time medium dynamics can not "wash out" the long-range rapidity
correlations that were formed at early times. These results may provide an
insight on the nature of the "ridge" correlations observed in heavy ion
collision experiments at RHIC and LHC, and in proton-proton collisions at LHC.Comment: 32 pages, 2 figures; v2: typos corrected, references adde
Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy
Both in humans and animal models, an acute increase in plasma insulin levels, typically following meals, leads to transient depression of hepatic secretion of very low density lipoproteins (VLDL). One contributing mechanism for the decrease in VLDL secretion is enhanced degradation of apolipoprotein B100 (apoB100), which is required for VLDL formation. Unlike the degradation of nascent apoB100, which occurs in the endoplasmic reticulum (ER), insulin-stimulated apoB100 degradation occurs post-ER and is inhibited by pan-phosphatidylinositol (PI)3-kinase inhibitors. It is unclear, however, which of the three classes of PI3-kinases is required for insulin-stimulated apoB100 degradation, as well as the proteolytic machinery underlying this response. Class III PI3-kinase is not activated by insulin, but the other two classes are. By using a class I-specific inhibitor and siRNA to the major class II isoform in liver, we now show that it is class II PI3-kinase that is required for insulin-stimulated apoB100 degradation in primary mouse hepatocytes. Because the insulin-stimulated process resembles other examples of apoB100 post-ER proteolysis mediated by autophagy, we hypothesized that the effects of insulin in autophagy-deficient mouse primary hepatocytes would be attenuated. Indeed, apoB100 degradation in response to insulin was significantly impaired in two types of autophagy-deficient hepatocytes. Together, our data demonstrate that insulin-stimulated apoB100 degradation in the liver requires both class II PI3-kinase activity and autophagy. © 2013 Andreo et al
Physics Opportunities of e+e- Linear Colliders
We describe the anticipated experimental program of an e+e- linear collider
in the energy range 500 GeV -- 1.5 TeV. We begin with a description of current
collider designs and the expected experimental environment. We then discuss
precision studies of the W boson and top quark. Finally, we review the range of
models proposed to explain the physics of electroweak symmetry breaking and
show, for each case, the central role that the linear collider experiments will
play in elucidating this physics. (to appear in Annual Reviews of Nuclear and
Particle Science)Comment: 93 pages, latex + 23 figures; typos corrections + 1 reference adde
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