7,823 research outputs found
Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells
Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES
Receipt from New York Botanical Gardens to Ogden Goelet
https://digitalcommons.salve.edu/goelet-personal-expenses/1038/thumbnail.jp
Is Improving Access to University Enough? Socio-Economic Gaps in the Earnings of English Graduates
Much research and policy attention has been on socio-economic gaps in participation at university, but less attention has been paid to socio-economic gaps in graduates' earnings. This paper addresses this shortfall using tax and student loan administrative data to investigate the variation in earnings of English graduates by socio-economic background. We fi nd that graduates from higher income families (with median income of around 26,000). Once we condition on institution and subject choices, this premium roughly halves, to around 10%. The premium grows with age and is larger for men, in particular for men at the most selective universities. We estimate the extent to which different institutions and subjects appear to deliver good earnings for relatively less well off students, highlighting the
good performance of medicine, economics, law, business, engineering, technology and computer science, as well as the prominent London-based universities.Nuffield Foundation
British Academ
Study of a Large NaI(Tl) Crystal
Using a narrow band positron beam, the response of a large high-resolution
NaI(Tl) crystal to an incident positron beam was measured. It was found that
nuclear interactions cause the appearance of additional peaks in the low energy
tail of the deposited energy spectrum
High Purity Pion Beam at TRIUMF
An extension of the TRIUMF M13 low-energy pion channel designed to suppress
positrons based on an energy-loss technique is described. A source of beam
channel momentum calibration from the decay pi+ --> e+ nu is also described.Comment: 5 page
14th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2011): Preface
No abstract available
Effects of Contact Network Models on Stochastic Epidemic Simulations
The importance of modeling the spread of epidemics through a population has
led to the development of mathematical models for infectious disease
propagation. A number of empirical studies have collected and analyzed data on
contacts between individuals using a variety of sensors. Typically one uses
such data to fit a probabilistic model of network contacts over which a disease
may propagate. In this paper, we investigate the effects of different contact
network models with varying levels of complexity on the outcomes of simulated
epidemics using a stochastic Susceptible-Infectious-Recovered (SIR) model. We
evaluate these network models on six datasets of contacts between people in a
variety of settings. Our results demonstrate that the choice of network model
can have a significant effect on how closely the outcomes of an epidemic
simulation on a simulated network match the outcomes on the actual network
constructed from the sensor data. In particular, preserving degrees of nodes
appears to be much more important than preserving cluster structure for
accurate epidemic simulations.Comment: To appear at International Conference on Social Informatics (SocInfo)
201
Spatial and spatio-temporal patterns in a cell-haptotaxis model
We investigate a cell-haptotaxis model for the generation of spatial and spatio-temporal patterns in one dimension. We analyse the steady state problem for specific boundary conditions and show the existence of spatially hetero-geneous steady states. A linear analysis shows that stability is lost through a Hopf bifurcation. We carry out a nonlinear multi-time scale perturbation procedure to study the evolution of the resulting spatio-temporal patterns. We also analyse the model in a parameter domain wherein it exhibits a singular dispersion relation
- …