Pbte Quantum Dots In Tellurite Glass Microstructured Optical Fiber

PbTe doped tellurite glass photonic optical fiber for non linear application were developed using rod in tube method in a draw tower. We follow the growth kinetics of the quantum dots in the optical fiber by High Resolution Transmission Electron Microscopy giving some results related with the growth kinetic of the same in function of time so much for optical fiber as for the glass bulk. Absorption peak near 1500 nm as observed and it was attributed the optical resonance due PbTe quantum dots in the core fiber.6902Tsunetomo, K., (1995) Nonlinear Opt, 13, p. 109Borrelli, N.F., Smith, D.W., (1994) J. Non-Cryst. Soi, 180, p. 25Lipovskii, A., Kolobkova, E.A., Petrikov, V., Kang, I., Olkhovets, A., Krauus, T., Thomas, M., Kycia, S., (1997) Appl. Phys. Lett, 71, p. 3406Reynoso, V.C.S., de Paula, A.M., Cuevas, R.F., Medeiros Neto, J.A., Alves, O.L., Cesar, C.L., Barbosa, L.C., (1995) Elect. Lett, 31 (12), pp. 1013-1014Rodrigues, E., Jimenez, E., Jacob, G.J., Neves, A.A.A., Cesar, C.L., Barbosa, L.C., (2005) Phisica E, 26, pp. 321-325Jacob, G.J., Cesar, C.L., Barbosa, L.C., Tellurite Glass Doped with PbTe Quantum Dots (2002) Physics and Chemistry of Glass, 43 C, pp. 250-253Jacob, G.J., Rodriguez, E., Barbosa, L.C., Cesar, C.L., Tellurite Glass Optical fiber doped with PbTe Quantum DotsPhotonics West 2005, The International Society for Optical Engineering SPIEEnomoto, Y., Tokuyama, M., Kawasaki, K., (1986) Act. Metall, 34, p. 2139Marqusee, J.A., Ross, J., (1984) J. Chem. Phys, 80, p. 536Lifshitz, E.M., Slyozov, V.V., (1961) J. Phys. Chem. Sol, 19, p. 3

Tellurite Photonic Crystal Fiber With Er3+-tm3+ For Broadband Optical Amplifier In 1550nm

Er3+-Tm3+ co-doped tellurite photonic crystal fiber was fabricated via a stack-and-draw procedure and without using extrusion in any stage. The final fiber presents a 187 nm bandwidth of amplified spontaneous emission (ASE) intensity around 1550nm when pumped with 790nm. In this manuscript a soft-glass tube fabrication technique, using the centrifugation method, is also shown.6116Knight, J.C., Birks, T.A., Russel, P.St.J., Atkin, D.M., All-silica single-mode optical fiber with photonic crystal cladding (1996) Opt. Lett, 21, pp. 1547-1549Jeong, H., Oh, K., Han, S.R., Morse, T.F., Characterization of broadband amplified spontaneous emission from an Er3+-Tm3+ -codoped silica fiber (2003) Opt. Lett, 367, pp. 507-511Chillcce, E.F., Rodriguez, E., Neves, A.A.R., Moreira, W.C., César, C.L., Barbosa, L.C., Er3+-Tm3+ co-doped tellurite fibers for broadband optical fiber amplifier around 1550 nm band (2005) Opt. Fiber Technol., , article in pressRussell, P., Photonic crystal fibers (2003) Science, 299, pp. 358-362Knight, J.C., Photonic crystal fibers (2003) Nature, 424, pp. 847-851Kumar, V.V.R.K., George, A.K., Knight, J.C., Russell, P.St.J., Tellurite photonic crystal fiber (2003) Opt. Exp, 20, pp. 2641-2645Kumar, V.V.R.K., George, A.K., Reeves, W.H., Knight, J.C., Russell, P.St.J., Omenetto, F.G., Taylor, A.J., Extruded soft glass photonic crystal fiber for ultrabroad supercontinuum generation (2002) Opt. Exp, 10 (25), pp. 1520-1525Kiang, K.M., Frampton, K., Monro, T.M., Moore, R., Tucknott, J., Hewak, D.W., Richardson, D.J., Rutt, H.N., Extruded singlemode non-silica glass holey optical fiber (2002) Electron. Lett, 38 (12), pp. 546-54

FGFR1 and PROKR2 rare variants found in patients with combined pituitary hormone deficiencies.

The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Using a candidate gene approach, we screened 156 Brazilian patients with combined pituitary hormone deficiencies (CPHD) for loss-of-function mutations in FGFR1 and PROKR2. We identified three FGFR1 variants (p.Arg448Trp, p.Ser107Leu and p.Pro772Ser) in four unrelated patients (two males) and two PROKR2 variants (p.Arg85Cys and p.Arg248Glu) in two unrelated female patients. Five of the six patients harbouring the variants had a first-degree relative that was an unaffected carrier of it. Results of functional studies indicated that the new FGFR1 variant p.Arg448Trp is a loss-of-function variant, while p.Ser107Leu and p.Pro772Ser present signalling activity similar to the wild-type form. Regarding PROKR2 variants, results from previous functional studies indicated that p.Arg85Cys moderately compromises receptor signalling through both MAPK and Ca(2) (+) pathways while p.Arg248Glu decreases calcium mobilization but has normal MAPK activity. The presence of loss-of-function variants of FGFR1 and PROKR2 in our patients with CPHD is indicative of an adjuvant and/or modifier effect of these rare variants on the phenotype. The presence of the same variants in unaffected relatives implies that they cannot solely cause the phenotype. Other associated genetic and/or environmental modifiers may play a role in the aetiology of this condition

Development Of Soft-glasses Photonic Crystal Fiber Made By Stacking-and-draw Technique

We have been able to produce soft glass conventional core-clad and micro-structured fibers using rod-and-tube and stack-and-draw method respectively. The stack-and-draw technique shows several difficulties when used with soft glasses, that we managed to avoid using two different lead and alkaline glasses. Non commercial glasses and fibers were thermo-mechanically and optically characterized.6469White, T.P., McPhedran, R.C., de Sterke, C.M., Botten, L.C., Steel, M.J., Confinement losses in micro structure optical fibers (2001) Opt. Lett, 26 (21), p. 1660Russell, P., Photonic crystal fibers (2003) Science, 299, pp. 358-362Knight, J.C., Photonic crystal fibers (2003) Nature, 424, pp. 847-851Chillcce, E.F., Cordeiro, C.M., Rodriguez, E., Brito Cruz, C.H., Cesar, C.L., Barbosa, L.C., Tellurite photonic crystal with Er 3+-Tm3+ for broadband optical amplifier in 1550nm (2006) Proc. of SPIE, 6116, p. 611604A. Hruby, Czech J. Phys. B, Evaluation of glass-forming tendency by means of DTA 1972, 22, 118

Cardiovascular abnormalities in patients with oral cleft: a clinical-electrocardiographic-echocardiographic study

OBJECTIVES: The present study aims to describe the clinical, electrocardiographic, and echocardiographic cardiological findings in a group of patients with oral clefts. METHODS: This is a prospective cross-sectional study on 70 children (age range from 13 days to 19 years) with oral clefts who attended the multidisciplinary program of a university hospital from March 2013 to September 2014. The patients were evaluated by a pediatric cardiologist and underwent detailed anamnesis, physical examination, electrocardiogram, and echocardiogram. RESULTS: Sixty percent of the patients were male; 55.7% presented with cleft lip and palate, and 40.0% presented with health complaints. Comorbidities were found in 44.3%. Relevant pregnancy, neonatal, family and personal antecedents were present in 55.7%, 27.1%, 67.2%, and 24.3% of the patients, respectively. Regarding the antecedents, 15.2% of the patients presented with a cardiac murmur, 49.0% with a familial risk of developing plurimetabolic syndrome, and 6% with family antecedents of rheumatic fever. Electrocardiographic evaluation showed one case of atrioventricular block. Echocardiograms were abnormal in 35.7% of the exams, including 5 cases of mitral valve prolapse — one of which was diagnosed with rheumatic heart disease. CONCLUSION: The finding of a family risk of developing plurimetabolic syndrome and a diagnosis of rheumatic heart disease indicates that patients with oral clefts may be more prone to developing acquired heart disease. Thus, our findings highlight the importance of anamnesis and methodological triangulation (clinical-electrocardiographic-echocardiographic) in the investigation of patients with oral clefts and emphasize that cardiological follow-up to evaluate acquired and/or rhythm heart diseases is necessary. This strategy permits comorbidity prevention and individualized planned treatment