90 research outputs found

    Na sombra do VietnĂŁ: o nacionalismo liberal e o problema da guerra

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    Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

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    Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≄ II, EF ≀35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

    Reducing Software Costs and Improving Performance with Server Based Computing

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    SITE 2015 - Las Vegas, NV, United States, March 1-6, 2015Classroom computing in graduate education continues to grow as more and more schools include the use of sophisticated software programs in their curriculums. Unfortunately many of these statistics and modeling applications are quite expensive and require significant processing power. The Graduate School of Business and Public Policy at the Naval Postgraduate School is using server-based computing to control software costs and improve the performance of applications. This paper describes the school’s use of Microsoft’s Remote Desktop Services to deliver applications to networked student computers. The virtual delivery of the software, which runs on a server, eliminates the need to install the software on every student computer. Depending on the software licensing structure, this can significantly reduce the required number of licenses. For some applications it can also dramatically improve performance

    Thin-clients in the Classroom; Software Compatibility and a Survey of Systems

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    Prepared for E-Learn 2006, World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education, Honolulu, Hawaii, USA, October 200. The article of record as published may be located at http://www.editlib.org/p/23714Thin-client computing devices have several advantages over traditional networked PCs in an academic classroom environment. The most significant of these are lower cost, ease of maintenance and administration, lower power requirements and increased reliability. This study examined a variety of Windows applications being used in the Graduate School of Business and Public Policy at the Naval Postgraduate School. The majority of the programs were found to be compatible with the thin-client architecture. The study also found there are a wide variety of thin client devices on the market and it is important to test prospective devices to determine whether they satisfy all of the user's functional requirements

    Apple App Store as a business model supporting U.S. Navy

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    Excerpt from the Proceedings of the Ninth Annual Acquisition Research Symposium, Thursday Sessions, Volume IINaval Open Architecture (NOA) is the confluence of business and technical practices yielding modular, interoperable systems that adhere to open standards with published interfaces. This approach significantly increases opportunities for innovation and competition, enables re-use of components, facilitates rapid technology insertion, and reduces maintenance constraints. A key enabler of the NOA initiative is the Software Hardware Asset Reuse Enterprise (SHARE) repository. The repository was created in August 2006 to facilitate the reuse of software and thereby reduce future development costs. The total benefit of the repository will correspond to the quality and quantity of the applications deposited into it. Indisputably, the most successful software repository in the public sector is the Apple App Store. As of March 2012, Apple listed more than 500,000 available applications. The purpose of this research is to examine the business model of the App Store to identify which of its effective business practices might be applicable to the SHARE repository.Naval Postgraduate School Acquisition Research ProgramApproved for public release; distribution is unlimited

    Apple App Store as a Business Model Supporting U.S. Navy Requirements

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    Sponsored Report (for Acquisition Research Program)Naval Open Architecture (NOA) is the confluence of business and technical practices yielding modular, interoperable systems that adhere to open standards with published interfaces. This approach significantly increases opportunities for innovation and competition, enables re-use of components, facilitates rapid technology insertion, and reduces maintenance constraints. A key enabler of the NOA initiative is the Software Hardware Asset Reuse Enterprise (SHARE) repository. The repository was created in August 2006 to facilitate the reuse of software and thereby reduce future development costs. The total benefit of the repository will correspond to the quality and quantity of the applications deposited into it. Indisputably, the most successful software repository in the public sector is the Apple App Store. As of October 2011, Apple lists more than 425,000 applications available. The purpose of this research is to examine the business model of the App Store to identify which of its effective business practices might be applicable to the SHARE repository.Acquisition Research ProgramApproved for public release; distribution is unlimited

    ACMS: a prototype expert database for air combat maneuvering

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    In combat situations, a fighter pilot must deal with a large number of input variables and decision alternatives in a very short time. To have the greatest chance of success in an encounter, the pilot must have a viable game plan in mind before he engages with an enemy aircraft. This game plan comes about through many hours of expert training in various scenarios of actual and hypothetical situations. This study describes the design and implementation of a prototype expert database training system for air combat maneuvering. The architecture of the system integrates a rule-based expert system with a database in a loosely coupled fashion. The expert system component of the system uses its rule base, access to the database, the pilot input to arrive at its decision.http://archive.org/details/acmsprototypeexp1094530697Lieutenant, United States NavyApproved for public release; distribution is unlimited

    History of the 1960’s Environmental Revolution: The Roles of Rachel Carson & Presidents Kennedy and Johnson

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    Monday’s lecture was Brinkley’s first in advance of his new work. The event was sponsored through a collaboration between the SJU President’s Office and the Eugene McCarthy Center for Public Policy and Civic Engagement. “My book will be out in November, but I did want to kind of test run some ideas,” said Brinkley, a best-selling author, the Katherine Tsanoff Brown Chair in Humanities and professor of history at Rice University, a CNN presidential historian and a contributing editor at Vanity Fair. “This seemed to be a perfect place. I’ve read about Saint John’s and Saint Ben’s so often – whether it’s from studying issues of Indigenous people to studying (SJU alum and former U.S. Senator and presidential candidate) Eugene McCarthy. I haven’t been here before. But I did my doctorate at Georgetown, so I’ve known a lot of people who have gone here over the years. This seemed like a great opportunity to visit, though I wish I could have come when there was a football game on.
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