Hemispheric Processing in Conventional Metaphor Comprehension: The Role of General Knowledge

This study explored the relation between general knowledge and the hemispheric processing of metaphoric expressions in college age students. We hypothesized that prior knowledge influences how the hemispheres process metaphors in these individuals. In this study, 97 young (college-aged) adults completed a general knowledge and vocabulary test, and were then divided into high-knowledge/high-vocabulary and low-knowledge/low-vocabulary groups. Next, participants viewed word pairs consisting of conventional metaphors, novel metaphors, word pairs with a literal meaning, and unrelated word pairs. The first word in each pair was presented centrally, and the second was presented to the right visual field-left hemisphere (rvf-LH) or the left visual field-right hemisphere (lvf-RH), and participants indicated whether each pair was a meaningful expression. Accuracy results showed an interaction between general knowledge and visual-field hemisphere. Low-knowledge participants were more accurate for metaphors presented to the rvf-LH than the lvf-RH, whereas high-knowledge participants showed no accuracy differences between the hemispheres. We also found an interaction between vocabulary and visual field-hemisphere for conventional metaphors. Specifically, low-vocabulary participants showed a left-hemisphere accuracy advantage, but high-vocabulary participants showed similar accuracy patterns in both hemispheres. These results suggest that young adult readers who have more general knowledge process conventional metaphors similarly in both hemispheres, whereas young adult readers who have less general knowledge may rely more heavily on left-hemisphere processes during conventional metaphor comprehension

If it does take a village to raise a child, how should the village do it? Insights from the kids in places initiative

Cross-sector collaborations are some of the strategies used to promote early childhood development and wellbeing. Without these collaborations, key services for families with young children may be missed or even duplicated. By drawing from experiences in Canada and Italy, we share findings from a study that aimed to understand the factors that make cross-sector collaborations (CSC) succeed or fail. Specifically, the study focused on understanding how CSC promoting early child development are created, maintained, and consolidated; and on identifying the social psychological, organizational, and economic aspects of CSC that help or hinder their functioning. Based on qualitative analysis of data gathered from four focus groups and thirteen interviews conducted across seven Canadian and Italian communities, we conclude that the success of CSC depend of a series of factors that transcend context, language and culture

Expression and in vitro properties of guinea pig IL-5: comparison to human and murine orthologs.

Interleukin-5 (IL-5) is a key mediator of eosinophilic inflammation. The biological role of this cytokine in an allergic airway inflammatory response has been widely demonstrated in guinea pigs, yet the interaction of guinea pig IL-5 (gpIL-5) with its receptor has not been studied. Experiments were performed to quantitate the interaction of gpIL-5 with gpIL-5r and to compare this affinity with that of hIL-5 and mIL-5 and their cognate receptors. The cross-species affinity and agonist efficacy were evaluated to see if gpIL-5r had a restricted species reactivity (as is the case with mIL-5r) or did not distinguish between IL-5 orthologs (similar to hIL-5r). gpIL-5 was cloned using mRNA isolated from cells obtained by bronchoalveolar lavage. Recombinant gpIL-5 was expressed in T. ni insect cells and purified from spent media. Binding assays were performed using insect cells expressing hIL-5ralphabeta or gpIL-5ralphabeta1 as previously described (Cytokine, 12:858-866, 2000) or using B13 cells which express mIL-5r. The agonist potency and efficacy properties of each IL-5 ortholog were evaluated by quantitating the proliferative response of human TF-1 cells and murine B13 cells. gpIL-5 bound with high affinity to recombinant gpIL-5r as demonstrated by displacing [125I]hIL-5 (Ki = 160 pM). gpIL-5 also bound to hIL-5r with high affinity (Ki = 750 pM). hIL-5 and mIL-5 showed similar, high-affinity binding profiles to both gpIL-5r and hIL-5r. In contrast, gpIL-5 and hIL-5 did not bind to the mIL-5r as demonstrated by an inability to displace [125I]mIL-5, even at 1000-fold molar excess. These differences in affinity for IL-5r orthologs correlated with bioassay results: human TF-1 cells showed roughly comparable proliferative responses to guinea pig, human and murine IL-5 whereas murine B13 cells showed a strong preference for murine over guinea pig and human IL-5 (EC50 = 1.9, 2200 and 720 pM, respectively). Recombinant gpIL-5 binds to the gpIL-5r with high affinity, similar to that seen with the human ligand-receptor pair. gpIL-5r and hIL-5r do not distinguish between the three IL-5 orthologs whereas mIL-5r has restricted specificity for its cognate ligand

Implication of the overlap representation for modelling generalized parton distributions

Based on a field theoretically inspired model of light-cone wave functions, we derive valence-like generalized parton distributions and their double distributions from the wave function overlap in the parton number conserved s-channel. The parton number changing contributions in the t-channel are restored from duality. In our construction constraints of positivity and polynomiality are simultaneously satisfied and it also implies a model dependent relation between generalized parton distributions and transverse momentum dependent parton distribution functions. The model predicts that the t-behavior of resulting hadronic amplitudes depends on the Bjorken variable x_Bj. We also propose an improved ansatz for double distributions that embeds this property.Comment: 15 pages, 8 eps figure

Effective and efficient committee work: A Systematic overview of multidisciplinary literatures

An era of financial constraints calls for effective and efficient committee work when making collective decisions. A systematic search identified research literatures in business administration, health research and service development, and social psychology addressing decision making about highly technical issues by mixed groups of people. Existing empirical and theoretical syntheses were drawn together to identify learning about the structure, processes and environment of committees and the characteristics of effective chairing. Committee performance depends upon the individuals involved, their attributes and relationships; and the time available for a committee to explore their knowledge to make choices or solve problems. In general, groups with six to twelve members tend to perform better than those in either smaller or larger groups, especially when relying on virtual communication. Diverse groups take account of a range of opinions and enhance credibility and widespread acceptance and implementation of decisions but may be more difficult to convene and manage appropriately. However, where chairs manage conflict constructively, more varied membership leads to better performance and more reliable judgements. These small-scale interactions reflect the larger scale institutional relationships, hierarchies and cultures which act as a backdrop to committee activities. These findings suggest that effective committee performance is enhanced by: appointing members from all key stakeholder groups who between them bring the appropriate range in educational and functional background, while keeping the group size close to 6-12; appointing committee chairs for their facilitation skills and generalist background rather than specialist knowledge; allowing sufficient time to allow all relevant knowledge to be shared and evaluated through discussion, especially when judgements need to be made by committees with members who vary in status; applying formal consensus development processes; and, particularly when working virtually, considering the challenges of developing trust and cohesion, and integrating divergent perspectives

Antiferromagnetic interlayer exchange coupling across an amorphous metallic spacer layer

By means of magneto-optical Kerr effect we observe for the first time antiferromagnetic coupling between ferromagnetic layers across an amorphous metallic spacer layer. Biquadratic coupling occurs at the transition from a ferromagnetically to an antiferromagnetically coupled region. Scanning tunneling microscopy images of all involved layers are used to extract thickness fluctuations and to verify the amorphous state of the spacer. The observed antiferromagnetic coupling behavior is explained by RKKY interaction taking into account the amorphous structure of the spacer material.Comment: Typset using RevTex, 4 pages with 4 figures (.eps

Theology, News and Notes - Vol. 17, No. 02

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1195/thumbnail.jp

Sustainable land use in mountain regions under global change: synthesis across scales and disciplines

Mountain regions provide essential ecosystem goods and services (EGS) for both mountain dwellers and people living outside these areas. Global change endangers the capacity of mountain ecosystems to provide key services. The Mountland project focused on three case study regions in the Swiss Alps and aimed to propose land-use practices and alternative policy solutions to ensure the provision of key EGS under climate and land-use changes. We summarized and synthesized the results of the project and provide insights into the ecological, socioeconomic, and political processes relevant for analyzing global change impacts on a European mountain region. In Mountland, an integrative approach was applied, combining methods from economics and the political and natural sciences to analyze ecosystem functioning from a holistic human-environment system perspective. In general, surveys, experiments, and model results revealed that climate and socioeconomic changes are likely to increase the vulnerability of the EGS analyzed. We regard the following key characteristics of coupled human-environment systems as central to our case study areas in mountain regions: thresholds, heterogeneity, trade-offs, and feedback. Our results suggest that the institutional framework should be strengthened in a way that better addresses these characteristics, allowing for (1) more integrative approaches, (2) a more network-oriented management and steering of political processes that integrate local stakeholders, and (3) enhanced capacity building to decrease the identified vulnerability as central elements in the policy process. Further, to maintain and support the future provision of EGS in mountain regions, policy making should also focus on project-oriented, cross-sectoral policies and spatial planning as a coordination instrument for land use in general

How the other half lives: CRISPR-Cas's influence on bacteriophages

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or plasmids. The threat from mobile genetic elements inevitably shapes the CRISPR loci of archaea and bacteria, and simultaneously the CRISPR-Cas immune system drives evolution of these invaders. Here we highlight our recent work, as well as that of others, that seeks to understand phage mechanisms of CRISPR-Cas evasion and conditions for population coexistence of phages with CRISPR-protected prokaryotes.Comment: 24 pages, 8 figure