Tecnologias de Internet em uma plataforma de colaboração para a pesquisa médica

Web technologies have changed software development. The changes affect a full range of applications as well as the way users interact with computers. In the health domain, clinical research demands a lot of investment, effort and information in order to safely commercialize a new drug. The WebInVivo project aims at providing automated support for clinical research based on Web technologies. It includes mechanisms for sharing and reusing clinical trial information, such as protocols, protocol data, workflows and workflow metadata and for controlling the protocol life cycle, from modeling to execution. In this project, knowledge from the biomedical area permeates three segments of Brazilian society: (a) research and development, (b) health agents, and (c) the population. This knowledge will be made available through social networks for these segments of Brazilian society.As tecnologias de Internet mudaram o desenvolvimento de software. As mudanças afetam uma gama completa de aplicações, assim como a forma em que os usuários interagem com os computadores. No campo da saúde, a pesquisa médica demanda muito investimento, esforço e informações para a comercialização segura de um fármaco novo. O projeto WebInVivo visa fornecer suporte automatizado à pesquisa médica, alicerçado em tecnologias de Internet. Ele inclui mecanismos para o compartilhamento e a reutilização de informações de pesquisas médicas, tais como protocolos, dados de protocolos, fluxos de trabalho e metadados de fluxos de trabalho para o controle do ciclo de vida do protocolo, da modelagem à execução. Neste projeto, o conhecimento da área biomédica permeia três segmentos da sociedade brasileira: (a) pesquisa e desenvolvimento, (b) agentes de saúde e (c) a população. Este conhecimento será disponibilizado em redes sociais, para esses segmentos da sociedade brasileira

Web technologies in a collaborative platform for clinical trials - DOI: 10.3395/reciis.v3i4.236en

Web technologies have changed software development. The changes affect a full range of applications as well as the way users interact with computers. In the health domain, clinical research demands a lot of investment, effort and information in order to safely commercialize a new drug. The WebInVivo project aims at providing automated support for clinical research based on Web technologies. It includes mechanisms for sharing and reusing clinical trial information, such as protocols, protocol data, workflows and workflow metadata and for controlling the protocol life cycle, from modeling to execution. In this project, knowledge from the biomedical area permeates three segments of Brazilian society: (a) research and development, (b) health agents, and (c) the population. This knowledge will be made available through social networks for these segments of Brazilian society

An innovative method to obtain porous PLLA scaffolds with highly spherical and interconnected pores

Scaffolding is an essential issue in tissue engineering and scaffolds should answer certain essential criteria: biocompatibility, high porosity, and important pore interconnectivity to facilitate cell migration and fluid diffusion. In this work, a modified solvent castingparticulate leaching out method is presented to produce scaffolds with spherical and interconnected pores. Sugar particles (200–300 lm and 300–500 lm) were poured through a horizontal Meker burner flame and collected below the flame. While crossing the high temperature zone, the particles melted and adopted a spherical shape. Spherical particles were compressed in plastic mold. Then, poly-L-lactic acid solution was cast in the sugar assembly. After solvent evaporation, the sugar was removed by immersing the structure into distilled water for 3 days. The obtained scaffolds presented highly spherical interconnected pores, with interconnection pathways from 10 to 100 lm. Pore interconnection was obtained without any additional step. Compression tests were carried out to evaluate the scaffold mechanical performances. Moreover, rabbit bone marrow mesenchymal stem cells were found to adhere and to proliferate in vitro in the scaffold over 21 days. This technique produced scaffold with highly spherical and interconnected pores without the use of additional organic solvents to leach out the porogen

Swine and Poultry Pathogens: the Complete Genome Sequences of Two Strains of Mycoplasma hyopneumoniae and a Strain of Mycoplasma synoviae

This work reports the results of analyses of three complete mycoplasma genomes, a pathogenic (7448) and a nonpathogenic (J) strain of the swine pathogen Mycoplasma hyopneumoniae and a strain of the avian pathogen Mycoplasma synoviae; the genome sizes of the three strains were 920,079 bp, 897,405 bp, and 799,476 bp, respectively. These genomes were compared with other sequenced mycoplasma genomes reported in the literature to examine several aspects of mycoplasma evolution. Strain-specific regions, including integrative and conjugal elements, and genome rearrangements and alterations in adhesin sequences were observed in the M. hyopneumoniae strains, and all of these were potentially related to pathogenicity. Genomic comparisons revealed that reduction in genome size implied loss of redundant metabolic pathways, with maintenance of alternative routes in different species. Horizontal gene transfer was consistently observed between M. synoviae and Mycoplasma gallisepticum. Our analyses indicated a likely transfer event of hemagglutinin-coding DNA sequences from M. gallisepticum to M. synoviae