Interstitial diagnosis and treatment of breast tumours

This thesis exploits the interaction of light with breast tissue for diagnosis and therapy. Optical biopsy is an experimental technique, based on Elastic Scattering Spectroscopy (ESS), being developed for characterising breast tissue. An optical probe interrogates tissue with a white light pulse, with spectral analysis of the reflected light. 264 spectral measurements (50 patients) were obtained from a range of breast tissues and axillary lymph nodes and correlated with conventional histology of biopsies from the same sites. Algorithms for spectral analysis were developed using ANN (Artificial Neural Network), HCA (Hierarchical Cluster Analysis) and MBA (Model Based Analysis). The sensitivity and specificity for cancer detection in breast and lymph nodes were: [diagram]. Interstitial Laser Photocoagulation (ILP) involves image guided, thermal coagulation of lesions within the breast using laser energy delivered via optical fibres positioned percutaneously under local anaesthetic. Two groups were studied: 1) Nineteen patients with benign fibroadenomas underwent ILP and the results compared with 11 treated conservatively. Thirteen ILP patients (14 fibroadenomas) and 6 controls (11 fibroadenomas) have reached their one-year review: [diagram]. These differences are statistically significant (P<0.001). 2)Six patients with primary breast cancers underwent ILP (with pre- and post-ILP contrast enhanced MRI) within 3 weeks of diagnosis and were then treated with Tamoxifen. Four underwent surgery at 3 months, two showing complete tumour ablation. MRI was reasonably accurate at detecting residual tumour. In conclusion: a) optical biopsy is a promising 'real time' diagnostic tool for breast disease. b) ILP could provide a simple and safe alternative to surgery for fibroadenomas. c) ILP with MRI monitoring may be an alternative to surgery in the management of some patients with localised primary breast cance

Improving the efficiency and relevance of health technology assessent: the role of iterative decision analytic modelling

Decision making in health care involves two sets of related decisions: those concerning appropriate service provision on the basis of existing information; and those concerned with whether to fund additional research to reduce the uncertainty relating to the decision. Information acquisition is not costless, and the allocation of funds to the enhancement of the decision makers’ information set, in a budgetconstrained health service, reduces the ‘pot’ of resources available for health service provision. Hence, a framework is necessary to unify these decisions and ensure that HTA is subject to the same evaluation of efficiency as service provision. A framework is presented which addresses these two sets of decisions through the employment of decision analytic models and Bayesian value of information analysis, early and regularly within the health technology assessment process. The model becomes the vehicle of health technology assessment, managing and directing future research effort on an iterative basis over the lifetime of the technology. This ensures consistency in decision making between service provision, research and development priorities and research methods. Fulfilling the aim of the National Health Service HTA programme, that research is “produced in the most economical way” using “cost effective research protocols”. The proposed framework is applied to the decision concerning the appropriate management of female patients with symptoms of urinary tract infection, which was the subject of a recent NHS HTA call for proposals. A probabilistic model is employed to fully characterise and assess the uncertainty surrounding the decision. The expected value of perfect information (EVPI) is then calculated for the full model, for each individual management strategy and for particular model parameters. Research effort can then be focused on those areas where the cost of uncertainty is high and where additional research is potentially cost-effective. The analysis can be used to identify the most appropriate research protocol and to concentrate research upon particular parameters where more precise estimates would be of most value.assessment

Repentir: Digital exploration beneath the surface of an oil painting

Repentir is a mobile application that employs marker-less tracking and augmented reality to enable gallery visitors to explore the under drawing and successive stages of pigment beneath an oil painting's surface. Repentir recognises the position and orientation of a specific painting within a photograph and precisely overlays images that were captured during that painting's creation. The viewer may then browse through the work's multiple states and closely examine its painted surface in one of two ways: sliding or rubbing. Our current prototype recognises realist painter Nathan Walsh's most recent work, "Transamerica". Repentir enables the viewer to explore intermediary stages in the painting's development and see what is usually lost within the materially additive painting process. The prototype offers an innovative approach to digital reproduction and provides users with unique insights into the painter's working method

No Oil Painting: digital originals and slow prints

Slow technology is…in part a reaction against the impulses toward instantaneity afforded by digital technology. This paper explores the slow work of a contemporary ‘analogue’ painter in the context of current research enquiry into digital art, authenticity and value. A group of artists were recruited to take part in in depth interviews conducted in their studios. The paper describes the artist’s resolutely non digital practice and outlines a concept design for a ‘slow print’ based on his work

Work hard, party harder:drug use and sexual behaviour in young British casual workers in Ibiza, Spain

Background: Every summer, young people flock to nightlife-focused holiday resorts around the world to find casual work. Despite being exposed to hedonistic environments, often for several months, little is known about their substance use, sexual activity and health service needs over this extended amount of time abroad. Methods: A short anonymous questionnaire examining alcohol and drug use, sexual behaviour and use of health services was administered to young British casual workers aged 16–35 in San Antonio, Ibiza (n = 171). Results: 97.7% of casual workers used alcohol in Ibiza, and the majority (85.3%) used drugs. Almost half (43.5%) of all participants used a drug in Ibiza that they had never used in the UK. Most casual workers arrived in Ibiza without a partner or spouse (86.5%). Of these, 86.9% had sex during their stay and 50.0% had unprotected sex; often while under the influence of alcohol. Only 14.3% of those having unprotected sex with a new partner sought a sexual health check-up in Ibiza, although 84.1% intended to do this on their return to the UK. Conclusion: Substance use and sexual risk taking is widespread among young British casual workers in Ibiza. Such international nightlife resorts represent key settings for substance-related health and social problems, and for the international spread of sexually transmitted infections. Addressing the health needs of casual workers and the environments that permit and promote their excessive behaviour requires collaboration between authorities in home and destination countries and the tourism industry

The effects of hydration dehydration on rigid gas permeable contact lenses

The base curves of eighteen rigid gas permeable lenses of various powers and manufactors mere measured after hydration-dehydration cycles. The Halsey Lenscope allowed measuring of the central as well as peripheral base curves. The general trend of the measurements, verified the hypothesized flattening of the central and steepening of the peripheral base curve with medium and high minus tenses. This observation might explain the clinical mystery of a measured flattened base curve accompanied by symptoms of a tight lens

A Delta Once More: Restoring Riparian and Wetland Habitat in the Colorado River Delta

Outlines the delta's history and current political context, documents recent findings about the delta's partial recovery, and makes recommendations for maintaining existing flows to further benefit and sustain the remnant wetland ecosystems

Archaeology unearthing the invisible people: European women and children and Aboriginal people at South Australian shore-based whaling stations

Archaeological fieldwork in South Australia (the Archaeology of Whaling in South Australia or AWSA project) under the direction of Mark Staniforth, commenced in April 1997, involving the recording and subsequently the excavation of whaling station sites on the Eyre Peninsula, Kangaroo Island, and at Cape Jervis. The aim of this research is to investigate the activities of whalers in South Australia, especially those involved in whaling activity who have been previously neglected, namely women, children and Indigenous peoples. Funding of more than $40,000 for this project and the development of a website has come from a Flinders University URB establishment grant, the Ian Potter Foundation, the Australian National Center for Excellence in Maritime Archaeology (WA Maritime Museum) and a Small ARC grant

MR399: Forestry-Related Nonpoint Source Pollution in Maine: A Literature Review

A great deal of research effort has been devoted to the topic of erosion and sedimentation from forest lands. This report reviews the literature dealing with the potential sources of forestry-related nonpoint source pollution and impacts on surface water, with particular emphasis on those studies conducted in Maine and in the Northeast. This review is organized along the following topics: sediment, temperature, nitrate, phosphorus, acidity, and herbicides.https://digitalcommons.library.umaine.edu/aes_miscreports/1024/thumbnail.jp

Probing the Interior Environment of Carbon Nano-test-tubes

We report the filling of single walled carbon nanotubes with an electron spin-active fullerene species where a nitroxide radical is functionalized on the fullerene cage. High resolution transmission electron microscopy (HRTEM), optical absorption and electron spin resonance (ESR) are used to determine the rotational behavior of the encapsulated molecules and determine the polar nature of the nanotube interior