11,471 research outputs found

    MNDA dimerizes through a complex motif involving an N-terminal basic region

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    AbstractHuman myeloid cell nuclear differentiation antigen (MNDA) is a myelomonocytic lineage-specific protein that influences gene expression through interactions with other nuclear proteins and transcription factors. MNDA also self-associates and chemical cross-linking was used to demonstrate that MNDA forms a dimer. C-terminal and internal deletion mutants were used to identify two regions in the N-terminal half of MNDA essential for self-association. One region contains an imperfect leucine zipper and the second is highly enriched in basic residues. The sequences that are essential for dimerization are separated by a highly basic amphipathic α-helical region which was not required for dimerization

    Electrically driven spin resonance in a bent disordered carbon nanotube

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    Resonant manipulation of carbon nanotube valley-spin qubits by an electric field is investigated theoretically. We develop a new analysis of electrically driven spin resonance exploiting fixed physical characteristics of the nanotube: a bend and inhomogeneous disorder. The spectrum is simulated for an electron valley-spin qubit coupled to a hole valley-spin qubit and an impurity electron spin, and features that coincide with a recent measurement are identified. We show that the same mechanism allows resonant control of the full four-dimensional spin-valley space.Comment: 11 pages, 7 figure

    Cosmological Simulations of Normal-Branch Braneworld Gravity

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    We introduce a cosmological model based on the normal branch of DGP braneworld gravity with a smooth dark energy component on the brane. The expansion history in this model is identical to LambdaCDM, thus evading all geometric constraints on the DGP cross-over scale r_c. This model can serve as a first approximation to more general braneworld models whose cosmological solutions have not been obtained yet. We study the formation of large scale structure in this model in the linear and non-linear regime using N-body simulations for different values of r_c. The simulations use the code presented in (F.S., arXiv:0905.0858) and solve the full non-linear equation for the brane-bending mode in conjunction with the usual gravitational dynamics. The brane-bending mode is attractive rather than repulsive in the DGP normal branch, hence the sign of the modified gravity effects is reversed compared to those presented in arXiv:0905.0858. We compare the simulation results with those of ordinary LambdaCDM simulations run using the same code and initial conditions. We find that the matter power spectrum in this model shows a characteristic enhancement peaking at k ~ 0.7 h/Mpc. We also find that the abundance of massive halos is significantly enhanced. Other results presented here include the density profiles of dark matter halos, and signatures of the brane-bending mode self-interactions (Vainshtein mechanism) in the simulations. Independently of the expansion history, these results can be used to place constraints on the DGP model and future generalizations through their effects on the growth of cosmological structure.Comment: 17 pages, 10 figures; v2: minor changes; v3: references added; v4: added appendix on comparison with previous results; matches published version; v5: corrected Eqs. (2.4-2.5) and Fig. 1 following Ref. [28]; all following results unchange

    Self-Consistent Cosmological Simulations of DGP Braneworld Gravity

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    We perform cosmological N-body simulations of the Dvali-Gabadadze-Porrati braneworld model, by solving the full non-linear equations of motion for the scalar degree of freedom in this model, the brane bending mode. While coupling universally to matter, the brane-bending mode has self-interactions that become important as soon as the density field becomes non-linear. These self-interactions lead to a suppression of the field in high-density environments, and restore gravity to General Relativity. The code uses a multi-grid relaxation scheme to solve the non-linear field equation in the quasi-static approximation. We perform simulations of a flat self-accelerating DGP model without cosmological constant. The results of the DGP simulations are compared with standard gravity simulations assuming the same expansion history, and with DGP simulations using the linearized equation for the brane bending mode. This allows us to isolate the effects of the non-linear self-couplings of the field which are noticeable already on quasi-linear scales. We present results on the matter power spectrum and the halo mass function, and discuss the behavior of the brane bending mode within cosmological structure formation. We find that, independently of CMB constraints, the self-accelerating DGP model is strongly constrained by current weak lensing and cluster abundance measurements.Comment: 21 pages; 10 figures. Revised version matching published versio

    Digital multimedia books produced using iBooks Author for pre-operative surgical patient information

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    Presenting patients with medical information and ensuring informed consent can be difficult due to patients with varying levels of literacy, physical and mental disabilities and spoken languages. Patients obtaining information from external sources, such as the internet, can also be problematic as the information can be irrelevant, inaccurate or misleading. A patient satisfaction study was performed in order to assess the effectiveness of using ebooks in order to communicate pre and post surgical information to neurosurgical patients. 3 digital books were produced using iBooks Author (a free desktop publishing program designed by Apple) including ACDF (anterior cervical discectomy and fusion), lumbar laminectomy and lumbar discectomy. Each book contained written information organised into sections and chapters along with an array of multimedia elements including 3D animations, interactive diagrams, 3D models of anatomy and patient experience videos. 32 volunteer patients were then presented with the digital books via an iPad during their preoperative assessment and then asked to complete a questionnaire. The results demonstrated a demand for this type of digital presentation of medical information and also showed patients no longer felt the need to seek further information from external sources
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