Owner perceptions of their cat's quality of life when treated with a modified University of Wisconsin-Madison protocol for lymphoma

The objectives of this study were to assess owner perceptions of their cat’s quality of life during treatment for lymphoma with a doxorubicin-containing multi-agent chemotherapy protocol, whether various health-related parameters correlated with quality of life scores, and to assess owner satisfaction with the protocol

Effect of Free Jet on Refraction and Noise

This article investigates the role of a free jet on the sound radiated from a jet. In particular, the role of an infinite wind tunnel, which simulates the forward flight condition, is compared to that of a finite wind tunnel. The second configuration is usually used in experiments, where the microphones are located in a static ambient medium far outside the free jet. To study the effect of the free jet on noise, both propagation and source strength need to be addressed. In this work, the exact Green's function in a locally parallel flow is derived for a simulated flight case. Numerical examples are presented that show a reduction in the magnitude of the Green's function in the aft arc and an increase in the forward arc for the simulated flight condition. The effect of finite wind tunnel on refraction is sensitive to the source location and is most pronounced in the aft arc. A Reynolds-averaged Navier-Stokes solution (RANS) yields the required mean flow and turbulence scales that are used in the jet mixing noise spectrum calculations. In addition to the sound/flow interaction, the separate effect of source strength and elongation of the noise-generating region of the jet in a forward flight is studied. Comparisons are made with experiments for the static and finite tunnel cases. Finally, the standard free-jet shear corrections that convert the finite wind tunnel measurements to an ideal wind tunnel arrangement are evaluated

Long Term Thermal Stability In Air Of Ionic Liquid Based Alternative Heat Transfer Fluids For Clean Energy Production

The purpose of this study was to investigate the effect of long-term aging on the thermal stability and chemical structure of seven different ILs so as to explore their suitability for use as a heat transfer fluid. This was accomplished by heating the ILs for 15 weeks at 200�C in an oxidizing environment and performing subsequent analyses on the aged chemicals

Ethyl 4-{1-[(2,4-dinitro­phen­yl)hydrazono]eth­yl}-5-(2-naphthyl­methoxy­meth­yl)isoxazole-3-carboxyl­ate

The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004 ▶). Neuropharmacology, 46, 273–284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra­molecular N—H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane

The 2dF Galaxy Redshift Survey: power-spectrum analysis of the final data set and cosmological implications

We present a power-spectrum analysis of the final 2dF Galaxy Redshift Survey (2dFGRS), employing a direct Fourier method. The sample used comprises 221 414 galaxies with measured redshifts. We investigate in detail the modelling of the sample selection, improving on previous treatments in a number of respects. A new angular mask is derived, based on revisions to the photometric calibration. The redshift selection function is determined by dividing the survey according to rest-frame colour, and deducing a self-consistent treatment of k-corrections and evolution for each population. The covariance matrix for the power-spectrum estimates is determined using two different approaches to the construction of mock surveys, which are used to demonstrate that the input cosmological model can be correctly recovered. We discuss in detail the possible differences between the galaxy and mass power spectra, and treat these using simulations, analytic models and a hybrid empirical approach. Based on these investigations, we are confident that the 2dFGRS power spectrum can be used to infer the matter content of the universe. On large scales, our estimated power spectrum shows evidence for the ‘baryon oscillations' that are predicted in cold dark matter (CDM) models. Fitting to a CDM model, assuming a primordial ns= 1 spectrum, h= 0.72 and negligible neutrino mass, the preferred parameters are Ωmh= 0.168 ± 0.016 and a baryon fraction Ωb/Ωm= 0.185 ± 0.046 (1σ errors). The value of Ωmh is 1σ lower than the 0.20 ± 0.03 in our 2001 analysis of the partially complete 2dFGRS. This shift is largely due to the signal from the newly sampled regions of space, rather than the refinements in the treatment of observational selection. This analysis therefore implies a density significantly below the standard Ωm= 0.3: in combination with cosmic microwave background (CMB) data from the Wilkinson Microwave Anisotropy Probe (WMAP), we infer Ωm= 0.231 ± 0.02

Whole Genome Sequencing Highlights Genetic Changes Associated with Laboratory Domestication of C. elegans

Defining the mutational landscape when individuals of a species grow separately and diverge over many generations can provide insights into trait evolution. A specific example of this involves studying changes associated with domestication where different lines of the same wild stock have been cultivated independently in different standard environments. Whole genome sequence comparison of such lines permits estimation of mutation rates, inference of genes' ancestral states and ancestry of existing strains, and correction of sequencing errors in genome databases. Here we study domestication of the C. elegans Bristol strain as a model, and report the genome sequence of LSJ1 (Bristol), a sibling of the standard C. elegans reference wild type N2 (Bristol). The LSJ1 and N2 lines were cultivated separately from shortly after the Bristol strain was isolated until methods to freeze C. elegans were developed. We find that during this time the two strains have accumulated 1208 genetic differences. We describe phenotypic variation between N2 and LSJ1 in the rate at which embryos develop, the rate of production of eggs, the maturity of eggs at laying, and feeding behavior, all the result of post-isolation changes. We infer the ancestral alleles in the original Bristol isolate and highlight 2038 likely sequencing errors in the original N2 reference genome sequence. Many of these changes modify genome annotation. Our study provides a starting point to further investigate genotype-phenotype association and offers insights into the process of selection as a result of laboratory domestication

The 2dF Galaxy Redshift Survey: the blue galaxy fraction and implications for the Butcher—Oemler effect

We derive the fraction of blue galaxies in a sample of clusters at z < 0.11 and the general field at the same redshift. The value of the blue fraction is observed to depend on the luminosity limit adopted, cluster-centric radius and, more generally, local galaxy density, but it does not depend on cluster properties. Changes in the blue fraction are due to variations in the relative proportions of red and blue galaxies but the star formation rate for these two galaxy groups remains unchanged. Our results are most consistent with a model where the star formation rate declines rapidly and the blue galaxies tend to be dwarfs and do not favour mechanisms where the Butcher-Oemler effect is caused by processes specific to the cluster environmen

OpenSAFELY: a platform for analysing electronic health records designed for reproducible research

Electronic health records (EHRs) and other administrative health data are increasingly used in research to generate evidence on the effectiveness, safety, and utilisation of medical products and services, and to inform public health guidance and policy. Reproducibility is a fundamental step for research credibility and promotes trust in evidence generated from EHRs. At present, ensuring research using EHRs is reproducible can be challenging for researchers. Research software platforms can provide technical solutions to enhance the reproducibility of research conducted using EHRs. In response to the COVID-19 pandemic, we developed the secure, transparent, analytic open-source software platform OpenSAFELY designed with reproducible research in mind. OpenSAFELY mitigates common barriers to reproducible research by: standardising key workflows around data preparation; removing barriers to code-sharing in secure analysis environments; enforcing public sharing of programming code and codelists; ensuring the same computational environment is used everywhere; integrating new and existing tools that encourage and enable the use of reproducible working practices; and providing an audit trail for all code that is run against the real data to increase transparency. This paper describes OpenSAFELY’s reproducibility-by-design approach in detail