The formation of mixed germanium–cobalt carbonyl clusters: an electrospray mass spectrometric study, and the structure of a high-nuclearity [Ge₂Co₁₀(CO)₂₄]²⁻ anion

The reaction of [µ₄-Ge{Co₂(CO)₇}₂] with [Co(CO)₄]⁻ has been monitored by electrospray mass spectrometry to detect the cluster anions generated. Conditions giving known mixed Ge–Co carbonyl clusters were established, and a new high nuclearity cluster anion, [Ge₂Co₁₀(CO)₂₄]²⁻ was detected. Conditions for its formation were optimised and it was subsequently isolated as its [Et₄N]⁺ salt and characterised by single-crystal X-ray crystallography. The Ge₂Co₁₀ cluster core has a novel geometry with the two germanium atoms in semi-encapsulated positions, forming seven formal Ge–Co bonds. There are also eighteen formal Co–Co bonds. Corresponding reactions of [µ₄-Si{Co₂(CO)₇}₂] with [Co(CO)₄]⁻ were also investigated

A system of efficient, cost-effective, and customizable vaccines for use with multiple vaccine candidates

Most vaccines created today are costly to produce. In addition, the creation of new vaccines to combat emerging diseases such as novel influenza strains such as H1N1 and SARS is slow and not able to meet the demand early in the disease cycle. The current invention developed by researchers at the University of Missouri is a new vaccine platform utilizing inactivated spores that is easy to customize to a disease of interest. The time between identification of an emerging pathogen to vaccine creation can be shortened to as little as 3 weeks. By utilizing bacterial cells that to high titers in simple growth medium, large batches of vaccine can be made in little time with immunogenic proteins surface displayed on the spores. Cost and time savings are achieved because no protein purification steps are required. The spores are easily inactivated and stable in the absence of refrigeration. Bacterial spores are recognized by the immune system as foreign and have the natural ability to stimulate the immune system and lead to effective immune responses. Thus our platform system should not need the use of adjuvants to produce a robust immune response. Lastly, we have the ability to express proteins from different antigen sources to create a multivalent vaccine against multiple pathogens. Potential Areas of Applications: * Vaccine development and production Patent Status: U.S. Patent Application No. 12/391,060 Inventor(s): George C. Stewart; Brian M. Thompson Contact Info: Harriet F. Francis, MS; J.D. [email protected] 573-884-0374 Per Stromhaug, Ph.D., MBA [email protected] 573-884-355

The preparation and characterisation of monomeric and linked metal carbonyl clusters containing the closo-Si2Co4 pseudo-octahedral core

PhSiH3 reacts with [Co₄(CO)₁₂] at 50 °C in hydrocarbon solvents to give [(µ₄-SiPh)₂Co₄(CO)₁₁], 2c, shown by an X-ray crystal structure determination to have a pseudo-octahedral Si₂Co₄ core. Substituted aryl-silanes behaved similarly. Mixtures of PhSiH₃, H₃SiC₆H₄SiH₃ and [Co₄(CO)₁₂] in a ca. 2 1 2 ratio gave the dimeric cluster [{Co₄(µ₄-SiPh)(CO)₁₁Si}₂C₆H₄], 3a, which has the two Si₂Co₄ cores linked by a C₆H₄ group to give a rigid molecule which an X-ray structure analysis shows to be over 23 Å long. Related dimers linked by –(CH₂)₈– groups were isolated from mixtures of PhSiH₃, α ,ω-(H₃Si)₂(CH₂)₈ and [Co₄(CO)₁₂]. Electrochemical studies show the two cluster units in 3a do not interact electronically

Removal of toxic contaminates from polluted soil and water via bioremediation utilizing bacillus spores [abstract]

Atrazine, a widely used herbicide in North America, is one of the known pollutants that pose a potential threat to human health. The addition of naturally occurring degradative bacteria that can remediate these pollutants has been promising. The soil bacterium Pseudomonas sp. strain ADP produces the enzyme AtzA which modifies atrazine to the benign hydroatrazine. However, the current use of bacteria in bioremediation is limited. These bacteria need to compete for nutrients with the native populations of microorganisms in the contaminated soil to survive and to maintain a degradative population. Bacterial endospores are naturally resistant to harmful environments, such as acidic soil, heat, and dessication; and have the ability to persist in soil for long periods of time. We wanted to utilize the Bacillus spore as a vehicle to deliver degradative enzymes, such as AtzA, into the soil and allow the tethered enzymes to persist over time. We utilized two methods for the tethering of enzymes to the spore surface. The first method being a genetic fusion of degradative enzymes to the exosporium of Bacillus endospores, and the second method being a chemical linkage to the outer layers of the Bacillus exosporium. INVENTOR(S): Brian M. Thompson; George C. Stewart; and Chun-Ho Lin CONTACT INFO: Harriet F. Francis, MS; J.D.; [email protected]; 573.884.0374 Per Stromhaug, Ph.D., MBA; [email protected]; 573.884.355

The Impact of Living in Housing With Care and Support on Loneliness and Social Isolation:Findings From a Resident-Based Survey

BACKGROUND AND OBJECTIVES: Housing with care is often lauded as a way to combat loneliness and social isolation in later life. This study examined whether housing with care created better outcomes for residents in terms of loneliness and social isolation than they might expect if they were living in the community. RESEARCH DESIGN AND METHODS: A survey was distributed to residents of housing with care as part of the Diversity in Care Environments project. It was designed to enable comparison with the English Longitudinal Study of Ageing. Propensity score matching was applied to identify the effect of housing with care residence on loneliness and social isolation. RESULTS: People living in housing with care had lower levels of loneliness than would be expected if they lived in the general community, with an average treatment effect on the treated (ATT) of −0.407 (95% CI = −0.601, −0.214). In contrast, social isolation was found to be slightly higher for residents than would be expected if they were in the community (ATT = 0.134 [95% CI = 0.022, 0.247]). Higher social isolation appears driven by less frequent contact with friends and reduced organizational membership rather than any difference in contact with family and children. DISCUSSION AND IMPLICATIONS: Our research has shown a positive impact on subjective social experiences from housing with care residence, despite a slight increase in objective social isolation. The findings underscore the importance of looking at loneliness and social isolation as distinct concepts as well as the effectiveness of housing with care at improving later-life outcomes

Improving Summer/Autumn Feed Quality in New Zealand Hill Country

Pasture management in spring has a strong influence on pasture quality in summer and autumn in New Zealand hill country pastures. Manipulation of defoliation frequency and intensity during mid-late spring can impact summer and autumn pasture quality and quantity (Orr et al. 1988). Summer/autumn management is mainly concerned with maintaining herbage quality in summer wet areas and controlling animal pressure in summer dry areas for drought management and winter feed stocks (Clark 1994). Deferred grazing to transfer pasture growth from late spring into summer and autumn deficits is difficult due to detrimental effects on pasture quality, plant density and species composition (Sheath et al. 1987). Various grazing management models have been published to inform hill farmers of pasture management considerations during this period (Smith and Dawson 1977; Sheath and Bircham 1983; Sheath et al. 1987). It has previously been shown that management of late spring surpluses to restrict reproductive growth will increase summer pasture quality through a reduction in accumulated stem and dead material and an increase in clover content (Sheath et al. 1987). However, there is no information on the longevity of these effects. This trial aimed to determine the effect of different defoliation intensities during spring on herbage quality and composition throughout the subsequent summer-autumn period

Disagreeable Privacy Policies: Mismatches between Meaning and Users’ Understanding

Privacy policies are verbose, difficult to understand, take too long to read, and may be the least-read items on most websites even as users express growing concerns about information collection practices. For all their faults, though, privacy policies remain the single most important source of information for users to attempt to learn how companies collect, use, and share data. Likewise, these policies form the basis for the self-regulatory notice and choice framework that is designed and promoted as a replacement for regulation. The underlying value and legitimacy of notice and choice depends, however, on the ability of users to understand privacy policies. This paper investigates the differences in interpretation among expert, knowledgeable, and typical users and explores whether those groups can understand the practices described in privacy policies at a level sufficient to support rational decision-making. The paper seeks to fill an important gap in the understanding of privacy policies through primary research on user interpretation and to inform the development of technologies combining natural language processing, machine learning and crowdsourcing for policy interpretation and summarization. For this research, we recruited a group of law and public policy graduate students at Fordham University, Carnegie Mellon University, and the University of Pittsburgh (“knowledgeable users”) and presented these law and policy researchers with a set of privacy policies from companies in the e-commerce and news & entertainment industries. We asked them nine basic questions about the policies’ statements regarding data collection, data use, and retention. We then presented the same set of policies to a group of privacy experts and to a group of non-expert users. The findings show areas of common understanding across all groups for certain data collection and deletion practices, but also demonstrate very important discrepancies in the interpretation of privacy policy language, particularly with respect to data sharing. The discordant interpretations arose both within groups and between the experts and the two other groups. The presence of these significant discrepancies has critical implications. First, the common understandings of some attributes of described data practices mean that semi-automated extraction of meaning from website privacy policies may be able to assist typical users and improve the effectiveness of notice by conveying the true meaning to users. However, the disagreements among experts and disagreement between experts and the other groups reflect that ambiguous wording in typical privacy policies undermines the ability of privacy policies to effectively convey notice of data practices to the general public. The results of this research will, consequently, have significant policy implications for the construction of the notice and choice framework and for the US reliance on this approach. The gap in interpretation indicates that privacy policies may be misleading the general public and that those policies could be considered legally unfair and deceptive. And, where websites are not effectively conveying privacy policies to consumers in a way that a “reasonable person” could, in fact, understand the policies, “notice and choice” fails as a framework. Such a failure has broad international implications since websites extend their reach beyond the United States