6,039 research outputs found
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation
Objectives:
To evaluate the clinical and costeffectiveness
of capecitabine and tegafur with uracil
(UFT/LV) as first-line treatments for patients with
metastatic colorectal cancer, as compared with 5-
fluorouracil/folinic acid (5-FU/FA) regimens.
Data sources: Electronic databases, reference lists of
relevant articles and sponsor submissions were also
consulted.
Review methods:
Systematic searches, selection
against criteria and quality assessment were performed
to obtain data from relevant studies. Costs were
estimated through resource-use data taken from the
published trials and the unpublished sponsor
submissions. Unit costs were taken from published
sources, where available. An economic evaluation was
undertaken to compare the cost-effectiveness of
capecitabine and UFT/LV with three intravenous 5-
FU/LV regimens widely used in the UK: the Mayo, the
modified de Gramont regimen and the inpatient de
Gramont regimens.
Results:
The evidence suggests that treatment with
capecitabine improves overall response rates and has
an improved adverse effect profile in comparison with
5-FU/LV treatment with the Mayo regimen, with the
exception of hand–foot syndrome. Time to disease
progression or death after treatment with UFT/LV in
one study appears to be shorter than after treatment
with 5-FU/LV with the Mayo regimen, although it also
had an improved adverse effect profile. Neither
capecitabine nor UFT/LV appeared to improve healthrelated
quality of life. Little information on patient
preference was available for UFT/LV, but there was
indicated a strong preference for this over 5-FU/LV.
The total cost of capecitabine and UFT/LV treatments
were estimated at £2111 and £3375, respectively,
compared with the total treatment cost for the Mayo
regimen of £3579. Cost estimates were also presented
for the modified de Gramont and inpatient de Gramont
regimens. These were £3684 and £6155, respectively.
No survival advantage was shown in the RCTs of the
oral drugs against the Mayo regimen. Cost savings of
capecitabine and UFT/LV over the Mayo regimen were
estimated to be £1461 and £209, respectively. Drug
acquisition costs were higher for the oral therapies
than for the Mayo regimen, but were offset by lower
administration costs. Adverse event treatment costs
were similar across the three regimens. It was inferred
that there was no survival difference between the oral
drugs and the de Gramont regimens. Cost savings of
capecitabine and UFT/LV over the modified de
Gramont regimen were estimated to be £1353 and
£101, respectively, and over the inpatient de Gramont
regimen were estimated to be £4123 and £2870,
respectively.
Conclusions:
The results show that there are cost
savings associated with the use of oral therapies. No
survival difference has been proven between the oral
drugs and the Mayo regimen. In addition, no evidence
of a survival difference between the Mayo regimen and
the de Gramont regimens has been identified.
However, improved progression-free survival and an
improved adverse event profile have been shown for
the de Gramont regimen over the Mayo regimen.
Further research is recommended into the following
areas: quality of life data should be included in trials of
colorectal cancer treatments; the place of effective oral
treatments in the treatment of colorectal cancer, the
safety mechanisms needed to ensure compliance and
the monitoring of adverse effects; the optimum
duration of treatment; the measurement of patient
preference; and a phase III comparative trial of
capecitabine and UFT/LV versus modified de Gramont
treatment to determine whether there was any survival
advantage and to collate the necessary economic data
UniquID: A Quest to Reconcile Identity Access Management and the Internet of Things
The Internet of Things (IoT) has caused a revolutionary paradigm shift in
computer networking. After decades of human-centered routines, where devices
were merely tools that enabled human beings to authenticate themselves and
perform activities, we are now dealing with a device-centered paradigm: the
devices themselves are actors, not just tools for people. Conventional identity
access management (IAM) frameworks were not designed to handle the challenges
of IoT. Trying to use traditional IAM systems to reconcile heterogeneous
devices and complex federations of online services (e.g., IoT sensors and cloud
computing solutions) adds a cumbersome architectural layer that can become hard
to maintain and act as a single point of failure. In this paper, we propose
UniquID, a blockchain-based solution that overcomes the need for centralized
IAM architectures while providing scalability and robustness. We also present
the experimental results of a proof-of-concept UniquID enrolment network, and
we discuss two different use-cases that show the considerable value of a
blockchain-based IAM.Comment: 15 pages, 10 figure
Penning traps with unitary architecture for storage of highly charged ions
Penning traps are made extremely compact by embedding rare-earth permanent
magnets in the electrode structure. Axially-oriented NdFeB magnets are used in
unitary architectures that couple the electric and magnetic components into an
integrated structure. We have constructed a two- magnet Penning trap with
radial access to enable the use of laser or atomic beams, as well as the
collection of light. An experimental apparatus equipped with ion optics is
installed at the NIST electron beam ion trap (EBIT) facility, constrained to
fit within 1 meter at the end of a horizontal beamline for transporting highly
charged ions. Highly charged ions of neon and argon, extracted with initial
energies up to 4000 eV per unit charge, are captured and stored to study the
confinement properties of a one-magnet trap and a two-magnet trap. Design
considerations and some test results are discussed
Fe I Oscillator Strengths for the Gaia-ESO Survey
The Gaia-ESO Public Spectroscopic Survey (GES) is conducting a large-scale
study of multi-element chemical abundances of some 100 000 stars in the Milky
Way with the ultimate aim of quantifying the formation history and evolution of
young, mature and ancient Galactic populations. However, in preparing for the
analysis of GES spectra, it has been noted that atomic oscillator strengths of
important Fe I lines required to correctly model stellar line intensities are
missing from the atomic database. Here, we present new experimental oscillator
strengths derived from branching fractions and level lifetimes, for 142
transitions of Fe I between 3526 {\AA} and 10864 {\AA}, of which at least 38
are urgently needed by GES. We also assess the impact of these new data on
solar spectral synthesis and demonstrate that for 36 lines that appear
unblended in the Sun, Fe abundance measurements yield a small line-by-line
scatter (0.08 dex) with a mean abundance of 7.44 dex in good agreement with
recent publications.Comment: Accepted for publication in Mon. Not. R. Astron. So
Microsomal incubation test of potentially hemolytic drugs for glucose‐6‐phosphate dehydrogenase deficiency
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109761/1/cptclpt198354.pd
Virtual light-by-light scattering and the g factor of a bound electron
The contribution of the light-by-light diagram to the g factor of electron
and muon bound in Coulomb field is obtained. For electron in a ground state,
our results are in good agreement with the results of other authors obtained
numerically for large Z. For relatively small Z our results have essentially
higher accuracy as compared to the previous ones. For muonic atoms, the
contribution is obtained for the first time with the high accuracy in whole
region of Z.Comment: 10 pages, 3 figures, RevTe
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