A Corticothalamic Circuit Trades off Speed for Safety during Decision-Making under Motivational Conflict

Decisions to act while pursuing goals in the presence of danger must be made quickly but safely. Premature decisions risk injury or death, whereas postponing decisions risk goal loss. Here we show how mice resolve these competing demands. Using microstructural behavioral analyses, we identified the spatiotemporal dynamics of approach–avoidance decisions under motivational conflict in male mice. Then we used cognitive modeling to show that these dynamics reflect the speeded decision-making mechanisms used by humans and nonhuman primates, with mice trading off decision speed for safety of choice when danger loomed. Using calcium imaging in paraventricular thalamus and optogenetic inhibition of the prelimbic cortex to paraventricular thalamus pathway, we show that this speed-safety trade off occurs because increases in paraventricular thalamus activity increase decision caution, thereby increasing approach–avoid decision times in the presence of danger. Our findings demonstrate that a discrete brain circuit involving the paraventricular thalamus and its prefrontal input adjusts decision caution during motivational conflict, trading off decision speed for decision safety when danger is close. We identify the corticothalamic pathway as central to cognitive control during decision-making under conflict

The Relationship of Residence to Academic Performance in NCAA Division I Freshman Athletes

Numerous studies have been completed examining academic ability of student athletes. Since the mid 1980s, the NCAA has emphasized the importance of academics and mandated more stringent requirements for participation in intercollegiate athletics. These initial-eligibility standards have been successful in increasing overall graduation rates of student-athletes, but a number of concerns remain. The purpose of this study was to determine if a NCAA Division-I freshman student athlete’s place of residence on campus, as opposed to off campus, during his/her freshman year had a statistically significant relationship to academic performance. The participants of this study (N = 205) were surveyed individually to determine their place of residence and preference of residence during their freshman year. Academic performance at the end of the freshman year was obtained via the school’s database of academic records (Access Banner). Based on the results of this study, it was concluded that living in an on campus or off campus environment had no statistical relationship with how the NCAA D-I freshman student athletes performed academically. There were however, significant differences between gender. The findings warrant further discussion and continued research

Association polymorphism CSFM50 with weight gain in Hereford beef cattle.

Este foi o título do artigo submetido ao Congresso "Association of microsatellite CSFM50 with weaning weight in Hereford beef cattle", mas este foi o título publicado no Proceedings

A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II)

© 2016 Siva et al. Background: Stereotactic ablative body radiotherapy (SABR) is emerging as a non-invasive method for precision irradiation of lung tumours. However, the ideal dose/fractionation schedule is not yet known. The primary purpose of this study is to assess safety and efficacy profile of single and multi-fraction SABR in the context of pulmonary oligometastases. Methods/Design: The TROG 13.01/ALTG 13.001 clinical trial is a multicentre unblinded randomised phase II study. Eligible patients have up to three metastases to the lung from any non-haematological malignancy, each<5cm in size, non-central targets, and have all primary and extrathoracic disease controlled with local therapies. Patients are randomised 1:1 to a single fraction of 28Gy versus 48Gy in four fractions of SABR. The primary objective is to assess the safety of each treatment arm, with secondary objectives including assessment of quality of life, local efficacy, resource use and costs, overall and disease free survival and time to distant failure. Outcomes will be stratified by number of metastases and origin of the primary disease (colorectal versus non-colorectal primary). Planned substudies include an assessment of the impact of online e-Learning platforms for lung SABR and assessment of the effect of SABR fractionation on the immune responses. A total of 84 patients are required to complete the study. Discussion: Fractionation schedules have not yet been investigated in a randomised fashion in the setting of oligometastatic disease. Assuming the likelihood of similar clinical efficacy in both arms, the present study design allows for exploration of the hypothesis that cost implications of managing potentially increased toxicities from single fraction SABR will be outweighed by costs associated with delivering multiple-fraction SABR. Trials registration:ACTRN12613001157763 , registered 17th October 201

Bond graph based multiphysic modelling of anion exchange membrane water electrolysis cell

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordThis work is an attempt to develop and validate a graphical dynamical model of an AEM electrolysis cell based on Bond Graphs, an energy based tool that allows to represent multiphysics systems. The model of the cell lays a foundation for developing a complete representation for AEM electrolysers which can be used for simulation as well as for developing control algorithms and fault diagnosis. Parameter identification and model validation is achieved using experimental data.European Commissio