Vivere d’acqua. Archeologie tra Lio Piccolo e Altino

Vivere d’acqua. Archeologie tra Lio Piccolo e Altino: Mostra Archeologica, Centro Culturale Manin, Ca’ Savio (Comune di Cavallino-Treporti). La mostra mira a mettere in risalto le strutture e le forme del paesaggio dell’area lagunare/litoranea antica dell’attuale territorio di Lio Piccolo e Cavallino/Treporti. La narrazione ha come filo conduttore l’importante attività pionieristica condotta da “Tito” Ernesto Canal alla fine del secolo scorso, seguendo un percorso cronologico che si snoda dall’età imperiale romana fino al VI-VII secolo d.C. Attraverso l’esposizione dei materiali archeologici, che sono stati rinvenuti in occasione delle ricerche archeologiche e la ricostruzione delle strutture antiche, il visitatore può comprendere le complesse vicende insediative legate a un territorio molto dinamico, in sospeso tra terre, mare e lagune. In questi luoghi le comunità, profondamente collegate al centro di Altino, hanno imparato a costruire, vivere e “dare forma e struttura” alle acque ed alle barene della Laguna. Qui si sono formati quei gruppi umani che hanno fatto di quell’ambiente la loro cultura. Il percorso espositivo, narrato in maniera semplice e diretta, vuole descrivere le caratteristiche di quelle che erano le infrastrutture della Laguna antica, tardoantica ed altomedievale: saline, peschiere e luoghi di approdo e di approvvigionamento idrico descrivono una zona a lungo sfruttata per la produzione di attività economiche molto redditizie e per il mantenimento dell’efficiente macchina portuale al servizio di Altino. Un focus specifico è dedicato alla villa romana di Lio Piccolo, luogo che ha un posto particolare nella memoria della comunità di Cavallino-Treporti e che ben racconta la vita lagunare di 2000 anni fa

Comparando técnicas terapêuticas para o manejo da úlcera péptica perfurada a partir de novos ensaios clínicos randomizados

A úlcera péptica pode ser caracterizada como um insulto à mucosa do trato digestivo superior, sendo resultado de um desequilíbrio entre ácido-pepsina do estômago e as barreiras de defesa da mucosa, a qual afeta em torno de 4 milhões de pessoas por ano em todo o mundo e com uma taxa de mortalidade de até 30%. O presente estudo de revisão buscou avaliar técnicas terapêuticas no manejo da úlcera péptica perfurada, documentadas por meio de ensaios clínicos randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: testes controlados e randomizados; artigos publicados nos últimos 05 anos (2018-2023); que possuíam texto completo disponível e que abordassem acerca de técnicas terapêuticas no manejo da úlcera péptica perfurada. Ficou constatado que a abordagem com stent juntamente com lavagem laparoscópica e drenagem se mostrou uma alternativa segura no manejo da úlcera duodenal perfurada. Além disso, verificou-se que a drenagem combinada endoscópica e radiológica intervencionista também se mostrou eficaz no tratamento da úlcera péptica aguda perfurada sem necessidade de anestesia geral e com um curto tempo de realização do procedimento

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Progetto Aquae Patavinae. Verso il Parco archeologico delle Terme Euganee

Our research benefited from the opportunity of analysing one of the most famous thermal water sites of the antiquity, Aquae Patavinae, in the Veneto territory, located immediately east of the eastern slopes of the Euganean Hills. The Aquae Patavinae Project has as its final objective the creation of the Terme Euganee Archaeological Park: a \u201cnetwork\u201d park, in which the places of interest are clearly visible in the current urban context and well connected to each other, accessible and comprehensible to the visitors and to the local community