Roadway System Assessment Using Bluetooth-Based Automatic Vehicle Identification Travel Time Data

This monograph is an exposition of several practice-ready methodologies for automatic vehicle identification (AVI) data collection systems. This includes considerations in the physical setup of the collection system as well as the interpretation of the data. An extended discussion is provided, with examples, demonstrating data techniques for converting the raw data into more concise metrics and views. Examples of statistical before-after tests are also provided. A series of case studies were presented that focus on various real-world applications, including the impact of winter weather on freeway operations, the economic benefit of traffic signal retiming, and the estimation of origin-destination matrices from travel time data. The technology used in this report is Bluetooth MAC address matching, but the concepts are extendible to other AVI data sources

Inhibitory control as a mediator of bidirectional effects between early oppositional behavior and maternal depression.

Maternal depression is an established risk factor for child conduct problems, but relatively few studies have tested whether children's behavioral problems exacerbate mothers' depression or whether other child behavioral characteristics (e.g., self-regulation) may mediate bidirectional effects between maternal depression and child disruptive behavior. This longitudinal study examined the parallel growth of maternal depressive symptoms and child oppositional behavior from ages 2 to 5; the magnitude and timing of their bidirectional effects; and whether child inhibitory control, a temperament-based self-regulatory mechanism, mediated effects between maternal depression and child oppositionality. A randomized control trial of 731 at-risk families assessed children annually from ages 2 to 5. Transactional models demonstrated positive and bidirectional associations between mothers' depressive symptoms and children's oppositional behavior from ages 2 to 3, with a less consistent pattern of reciprocal relations up to age 5. Mediation of indirect mother-child effects and child evocative effects depended on the rater of children's inhibitory control. Findings are discussed in regard to how child evocative effects and self-regulatory mechanisms may clarify the transmission of psychopathology within families

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development

In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnidarian model to study the origins of TLR signaling because its genome encodes a single TLR and homologs of many downstream signaling components, including the NF-κB pathway. We have characterized the single N. vectensis TLR (Nv-TLR) and demonstrated that it can activate canonical NF-κB signaling in human cells. Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact with the human TLR adapter proteins MAL and MYD88. We demonstrate that the coral pathogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated V. coralliilyticus and bacterial flagellin can activate a reconstituted Nv-TLR–to–NF-κB pathway in human cells. By immunostaining of anemones, we show that Nv-TLR is expressed in a subset of cnidocytes and that many of these Nv-TLR–expressing cells also express Nv-NF-κB. Additionally, the nematosome, which is a Nematostella-specific multicellular structure, expresses Nv-TLR and many innate immune pathway homologs and can engulf V. coralliilyticus. Morpholino knockdown indicates that Nv-TLR also has an essential role during early embryonic development. Our characterization of this primitive TLR and identification of a bacterial pathogen for N. vectensis reveal ancient TLR functions and provide a model for studying the molecular basis of cnidarian disease and immunity.IOS-1354935 - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); 1262934 - National Science Foundation (NSF); 2014-BSP - Arnold and Mabel Beckman Foundatio

Rumble Stripes: Opportunity to Improve Safety and Retroreflectivity

Painted rumble stripes can provide safety benefits as well as improved retroreflectivy and paint durability. This presentation covers specifications and construction techniques. A case study will describe the recent application of rumble stripes on US 231 between Crawfordsville and Lafayette, Indiana

Alternatives to Raised Pavement Markers (RPMs)

Empirical evidence shows that raised pavement markers (RPMs) can become dislodged from the pavement when struck by snowplows, presenting a road hazard. Furthermore, a dislodged RPM opens an ingress point for water to reach the sub pavement, potentially reducing the design life of the pavement. To address this issue, Indiana conducted an evaluation of centerline rumble stripes (CLRSs) as an alternative to RPMs on rural, non-interstate, roadways. Five pilot test sites consisting of 41.2 miles of roadway were constructed to evaluate CLRS performance in multiple regions of Indiana under various pavement conditions. CLRS were subsequently incorporated into INDOT’s 2013 Goals and approximately 238 project miles were programmed for construction. The project team participated in the development of a new specification for use in contract lettings after September 1, 2013. This technical report summarizes that evaluation, briefly summarizes the project background and development of CLRS specifications, provides detailed photos of a fall 2013 deployment, and summarizes the post—construction close out meeting held on December 4, 2013

Painted Rumble Stripes: Alternatives to Raised Pavement Markers (RPMs)

This poster highlights research completed by the Joint Transportation Research Program (JTRP) led by Darcy Bullock, Lyles School of Civil Engineering, Purdue University, for JTRP Project SPR-3528, Alternatives to Raised Pavement Markers (RPMs). The poster includes photos taken at a construction site on State Road 25 located near Shadeland, Indiana. The top photo demonstrates how the center line corrected a driver when snow covered to avoid oncoming traffic. Photo was taken on US 231 near Country Road 800 in Tippecanoe County

Can the United States Afford a “No-Fault” System of Compensation for Medical Injury?

One of the key issues separating US critics of a no-fault alternative to the tort system for compensating victims of medical injury from supporters is its anticipated cost. Results from a study are presented that estimate the costs of a no-fault system, one that is similar to the system now in operation in Sweden, within the context of the US health care system