Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

<p>Abstract</p> <p>Introduction</p> <p>Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I₂) have a antiproliferative and apoptotic effect either <it>in vivo </it>as <it>in vitro</it>, however the cellular intermediated involved in these effects has not been elucidated.</p> <p>Methods</p> <p>Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw) and the participation of arachidonic acid (AA) and PPAR receptors in the antineoplasic effect of I₂where analyzed.</p> <p>Results</p> <p>I₂-treated rats for four weeks exhibited a significant reduction in the incidence (62.5 vs. 100%) and size (0.87 ± 0.98 vs 1.96 ± 1.5 cm³) of mammary tumors. HPLC analysis showed that tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I₂treatment. Tumors from I₂-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARα). These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARγ).</p> <p>Conclusion</p> <p>Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARγ induction.</p

Actitud de los padres ante el uso de aditamentos de contención física en la consulta dental en pacientes con discapacidad.

En odontología, para pacientes con discapacidad, la cooperación del paciente durante la consulta no es la adecuada. En los casos donde las técnicas de manejo de conducta no funcionan se buscan alternativas para atender al paciente. Dentro de estas se encuentra  la contención física, cuyo objetivo es evitar que se produzcan situaciones que pongan en peligro la integridad física del paciente, el odontólogo y de su equipo de trabajo limitando el movimiento por medio de aditamentos físicos o mecánicos

Percepción de inseguridad en un entorno rural desde la perspectiva de género. El caso de Flor de coco en Colima, México

Este trabajo tiene como objetivo analizar, desde la perspectiva de género, la percepción que un grupo de mujeres de un poblado rururbano, con alta marginalidad, tienen de los espacios públicos y del contexto de sus viviendas. La investigación forma parte del proyecto Vivienda y mujer: espacios habitables para el desarrollo de familias con jefatura femenina en la comunidad de Flor de Coco, Municipio de Armería, Colima. Para el estudio se empleó una metodología cuali-cuantitativa con información de campo, entrevistas, talleres y el análisis del entorno inmediato de ocho viviendas con jefatura femenina. Los resultados muestran que existen diez tipos de inseguridad, desde la percepción de las mujeres: drogadicción, alcoholismo, robos y asaltos, violencia de género, pandillerismo, inseguridad por falta de iluminación, por falta de vigilancia, por riesgo de deslaves, por problemas de movilidad y por inundaciones y crecidas del río. Como señalan Nieto Morales y Esquivel Hernández, Soto Villagrán, Ortiz Escalante, Col-lectiu Punt 6 y Farapi, la ausencia de una planeación con perspectiva de género de la forma urbana y su espacio público afecta más a las mujeres, lo que las vuelve más vulnerables.

Ciencia Odontológica 2.0

Libro que muestra avances de la Investigación Odontológica en MéxicoEs para los integrantes de la Red de Investigación en Estomatología (RIE) una enorme alegría presentar el segundo de una serie de 6 libros sobre casos clínicos, revisiones de la literatura e investigaciones. La RIE está integrada por cuerpos académicos de la UAEH, UAEM, UAC y UdeG

Antineoplastic mechanisms of Iodine in cancers that take up Iodine

Purpose: In addition to being a component of thyroid hormone (TH), iodine can be an antioxidant as well as an antiproliferative and differentiation agent that helps to maintain the integrity of several organs with the ability to take up iodine.Methods and Results: Studies from our laboratory shown that in preclinical (cell culture, induced animal cancer and xenographs) and clinical studies (mammary cancer protocol), molecular iodine (I2) supplementation exerts suppressive effects on implantation, development, and progression of cancer neoplasias. These effects can be mediated by a variety of mechanisms and pathways, including direct actions, in which the oxidized iodine modulates the immune/tumor response and through iodolipid formation and the activation of peroxisome proliferator-activated receptors type gamma (PPARγ) triggering apoptotic and/or differentiation pathways.Conclusion: The absence of side effects and the easy availability and handling of I2 have allowed the establishment of clinical protocols to utilize I2 supplementation as an adjuvant in therapies against cancers that take up iodine.-----------------------------------------Cite this article as:  Aceves C, Anguiano B. Antineoplastic mechanisms of Iodine in cancers that take up Iodine. Int J Cancer Ther Oncol 2015; 3(4):3401.[This abstract was presented at the BIT’s 8th Annual World Cancer Congress, which was held from May 15-17, 2015 in Beijing, China.]</p

Antineoplastic mechanisms of Iodine in cancers that take up Iodine

Purpose: In addition to being a component of thyroid hormone (TH), iodine can be an antioxidant as well as an antiproliferative and differentiation agent that helps to maintain the integrity of several organs with the ability to take up iodine.Methods and Results: Studies from our laboratory shown that in preclinical (cell culture, induced animal cancer and xenographs) and clinical studies (mammary cancer protocol), molecular iodine (I2) supplementation exerts suppressive effects on implantation, development, and progression of cancer neoplasias. These effects can be mediated by a variety of mechanisms and pathways, including direct actions, in which the oxidized iodine modulates the immune/tumor response and through iodolipid formation and the activation of peroxisome proliferator-activated receptors type gamma (PPARγ) triggering apoptotic and/or differentiation pathways.Conclusion: The absence of side effects and the easy availability and handling of I2 have allowed the establishment of clinical protocols to utilize I2 supplementation as an adjuvant in therapies against cancers that take up iodine.-----------------------------------------Cite this article as:  Aceves C, Anguiano B. Antineoplastic mechanisms of Iodine in cancers that take up Iodine. Int J Cancer Ther Oncol 2015; 3(4):3401.[This abstract was presented at the BIT’s 8th Annual World Cancer Congress, which was held from May 15-17, 2015 in Beijing, China.

Understanding and Addressing the California Latino Achievement Gap in Early Elementary School

One of the most pressing problems in California is improving student academic performance, especially the state’s burgeoning Latino student population. This study examined the extent of the achievement gap between Latino and White students over the first two years of elementary school and the characteristics of students and schools that contribute to it. The analysis revealed that Latino students begin kindergarten at a considerable educational disadvantage relative to White students and the disadvantage increases during the first two years of school. Yet schools do little to widen or narrow these differences. Instead achievement differences increase when students are not in school. Consequently, to reduce the achievement gap will require both effective education policies and policies that address the overall social welfare of Latinos outside of school

Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator

Most investigations of iodine metabolism in humans and animals have focused on its role in thyroid function. However, considerable evidence indicates that iodine could also be implicated in the physiopathology of other organs. We review the literature that shows that molecular iodine (I2) exerts multiple and complex actions on the organs that capture it, not including its effects as part of thyroid hormones. This chemical form of iodine is internalized by a facilitated diffusion system that is evolutionary conserved, and its effects appear to be mediated by a variety of mechanisms and pathways. As an oxidized component, it directly neutralizes free radicals, induces the expression of type II antioxidant enzymes, or inactivates proinflammatory pathways. In neoplastic cells, I2 generates iodolipids with nuclear actions that include the activation of apoptotic pathways and the inhibition of markers related to stem cell maintenance, chemoresistance, and survival. Recently, I2 has been postulated as an immune modulator that depending on the cellular context, can function as an inhibitor or activator of immune responses. We propose that the intake of molecular iodine is increased in adults to at least 1 mg/day in specific pathologies to obtain the potential extrathyroid benefits described in this review