Оценка точности химико-аналитических приборов по результатам их градуировки

In the production of micro devices for applications in chemistry, biotechnology and medical technologies surface properties become more and more important The microscale topography and surface chemistry have influence on wetting properties and cell behavior. Therefor the design of material surface determines the success of artificial devices in contact with biological systems. For applications in the field of medical implants laser technologies have been developed for micro structuring of polymers to modify the surface properties with respect to wettability and controlled cell growth. The technology is based on excimer laser treatment of polymer surfaces using laser wavelength 193 nm (ArF) with different fluences and cumulated energies. Depending on the processing parameters and examined polymers either hydrophobic or hydrophilic surfaces can be increased. The water contact angle of polydimethylsiloxane (PDMS) for example can be increased from 113° to approx. 150° so that the surface exhibits the so called lotus effect. The laser generated micro patterns reveal influence on cell density and cell distribution which can be used for cell guidance. Results for cell growing experiments are shown for different polymers

MANAGEMENT DECISION MAKING IN MARKETING

Miniaturized microreactors enable photochemistry with laser irradiation in flow mode to convert azidobiphenyl into carbazole with high efficiency

Photochemistry with laser radiation in condensed phase using miniaturized photoreactors

Miniaturized microreactors enable photochemistry with laser irradiation in flow mode to convert azidobiphenyl into carbazole with high efficiency

Тепловая экономичность привода питательных насосов электростанций

In the production of micro devices the surface properties become more and more important for chemistry, biotechnology and medical technology with respect to wetting properties and chemical composition of the surface. Typical applications are implants as well as micro fluidic systems or miniaturized devices for DNA- and proteome analysis (biochips). In this paper newly designed laser technologies based on UV-laser treatment of polymers for surface processing are described to manipulate wetting properties, cell growth and immobilization of functional molecules with high spatial resolution. Depending on the processing parameters and used polymers either hydrophobic or hydrophilic properties can be enhanced (i.e. laser induced lotus/anti-lotus effect). Enhanced roughness and changes of the chemical composition have also influence on cell growth on polymer surfaces. Thus guiding aids for cells e.g. on medical implants can be generated by laser irradiation. Due to photo oxidation processes while UV-treatment in air, functional groups are created that are suited for covalent bonding of (bio)moelcules onto the surfaces. A second process for the locally selective immobilization of anchor molecules based on azide functionalized templates suitable for further modification steps is presented by means of irradiating polymers under solutions of these linkers

Использование аналитики при создании бренда территории

Рассматриваются компоненты брендинга и бренда территории, раскрываются возможности использования аналитики при его создании и продвижении. Под аналитикой понимается обширное использование данных, статистического и количественного анализа, описательных и прогнозных моделей для принятия решений и действий, на основе реальных фактов. Делается вывод о том, что аналитика является наиболее эффективным механизмом при создании и продвижении бренда территории

Strukturierung und Modifizierung von Polymeren mit UV-Laserstrahlung für life science Anwendungen

The objective of this work was the development of new processing technologies with UV-laser radiation for high performance and biocompatible polymers in life science applications. The laser treated surfaces were characterized by a variety surface sensitive of methods. In these polymers different surface topologies were generated by ablation in order to study their wetting properties by measurement of water contact angles. With this protocol it was possible to generate a Lotus-effect on hydrophobic polymers like PDMS and an "anti"Lotus-Effect in more hydrophilic polymers like PEEK. No negative influence on the biocompatibility of polymer surfaces caused by laser treatment has been detected. Guided cell growth was stimulated along geometrically defined groves generated by laser ablation. Furthermore cells proliferate well through laser drilled holes. On PDMS the parameters for laser drilling of small geometrically defined holes were optimized and the holes were characterized. A special procedure based on the use of a protective coating was developed to avoid the build-up of debris around small structures. As an application of this methodology a laser drilled retina implant is described. The chemical changes on polymer surfaces caused by laser treatment in air have been examined on selected polymers. New functionalities generated by photo oxidation were identified by derivatization with fluorescent dyes. The functionalized micro structures were detected by florescence microscopy. Reactive compounds like azides were immobilized out of a solution surrounding the polymer onto its surface with high spatial resolution by use of laser radiation. This procedure for polymer surface modification might stimulate further research into the immobilization of bioactive molecules e.g. for applications in biochips

Information technology organization of Building project management offices

Розглянуто процеси організації офісу проекту крізь призму бізнес-процесів загального управління будівельними проектами. Проаналізовано роль інформаційної технології у створенні системи управління будівельними проектами відповідно до вимог проектного менеджменту. На основі процесного підходу запропоновано структурну модель інформаційної технології організації офісу в будівельній компанії.Determined process of the formatted project management office through biasness–process of total building project management. The phenomenon of information system to the system building project management. have been analyzed. Represented the structural model of the information technology organization of project management office in building company which based process method

Strukturierung und Modifizierung von Polymeren mit UV-Laserstrahlung für life science Anwendungen

The objective of this work was the development of new processing technologies with UV-laser radiation for high performance and biocompatible polymers in life science applications. The laser treated surfaces were characterized by a variety surface sensitive of methods. In these polymers different surface topologies were generated by ablation in order to study their wetting properties by measurement of water contact angles. With this protocol it was possible to generate a Lotus-effect on hydrophobic polymers like PDMS and an "anti"Lotus-Effect in more hydrophilic polymers like PEEK. No negative influence on the biocompatibility of polymer surfaces caused by laser treatment has been detected. Guided cell growth was stimulated along geometrically defined groves generated by laser ablation. Furthermore cells proliferate well through laser drilled holes. On PDMS the parameters for laser drilling of small geometrically defined holes were optimized and the holes were characterized. A special procedure based on the use of a protective coating was developed to avoid the build-up of debris around small structures. As an application of this methodology a laser drilled retina implant is described. The chemical changes on polymer surfaces caused by laser treatment in air have been examined on selected polymers. New functionalities generated by photo oxidation were identified by derivatization with fluorescent dyes. The functionalized micro structures were detected by florescence microscopy. Reactive compounds like azides were immobilized out of a solution surrounding the polymer onto its surface with high spatial resolution by use of laser radiation. This procedure for polymer surface modification might stimulate further research into the immobilization of bioactive molecules e.g. for applications in biochips