458 research outputs found
ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΡΠΈ ΠΏΡΠΎΡΡΠ°ΡΠΈΡΠ΅/ΡΠΈΠ½Π΄ΡΠΎΠΌΠ΅ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ
ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π΅Π»Π΅ΡΠ΅Π½Π½ΠΎΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΏΠ΅ΡΠΌΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΈ Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΊ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ ΠΏΡΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠΎΠ»ΠΎΠ²ΡΡ
ΠΆΠ΅Π»Π΅Π· ΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΌ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΠ°ΠΊΡΠ΅ΡΠΈΠΈ, Π²ΠΈΡΡΡΡ, Π»Π΅ΠΉΠΊΠΎΡΠΈΡΡ, ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠ΅ ΡΠ°Π΄ΠΈΠΊΠ°Π»Ρ, ΡΠΈΡΠΎΠΊΠΈΠ½Ρ, ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΡ ΡΠ΅ΠΌΡΠ²ΡΠ²ΠΎΠ΄ΡΡΠΈΡ
ΠΏΡΡΠ΅ΠΉ ΠΏΡΠΈ ΠΏΡΠΎΡΡΠ°ΡΠ΅ ΡΠ²Π»ΡΡΡΡΡ ΠΊΠΎΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ.It is shown that untreated chronic inflammation of the prostate gland causes disturbances of spermogram count and strility in a number of cases at normal development of sex glands and sufficient hormone supply of the organism. Bacteria, viruses, leukocytes, free radicals, cytokines, immunological changes and obstruction of the deferent ducts in prostatitis are coβfactors of sterility development
Assessment of oesophageal emptying in achalasia patients by intraluminal impedance monitoring
Oesophageal emptying can be assessed by radiographic and scintigraphic tests with radiation exposure or by multichannel intraluminal impedance monitoring (MII). The aim of this study was to evaluate the applicability of MII for the assessment of oesophageal emptying in achalasia patients. In 10 achalasia patients, impedance tracings were scored independently by three observers after ingestion of a 100-mL barium bolus. Bolus clearance time (BCT) and height of barium column were scored using fluoroscopic images acquired at 20-s intervals. All patients showed a low baseline impedance level in the distal oesophagus. Air trapping in the proximal oesophagus was detected in nine patients. BCT on MII was similar to that on fluoroscopy in 40-70% of the patients. Correlations between height of barium on fluoroscopy and fluid level on MII were poor to moderate at different time intervals. Concordance (Kendall's coefficient) between the three observers for assessment of fluid level on MII was 0.31 (P = 0.04) at 1 and 5 min, 0.26 (P = 0.08) at 10 and 0.44 (P = 0.01) at 15 min. We conclude that in achalasia patients, low baseline impedance levels and air entrapment in the proximal oesophagus limit the value of intraluminal impedance monitoring as a test of oesophageal emptying
ΠΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Ρ ΠΊΡΠΎΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΡΠΉΠ½ΠΎΡ Π²ΠΈΡΠΎΠΊΠΎΠ΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΠ΄ΠΈΠ½Π½ΠΎΡ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡΡ
ΠΠ΄ΡΠΉΡΠ½Π΅Π½Π° Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π· 3-(2'-Π±ΡΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ»)-7-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΡΠΌΠ°ΡΠΈΠ½ΠΎΠΌ Ρ ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΡ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ Ρ ΠΊΡΠΎΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΡΠΉΠ½ΠΎΡ Π²ΠΈΡΠΎΠΊΠΎΠ΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΠ΄ΠΈΠ½Π½ΠΎΡ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡΡ. ΠΠΈΠ²ΡΠ΅Π½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² ΡΡΠ·Π½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π΄Π΅ΠΏΡΠΎΡΠΎΡΠ½ΡΠ·Π°ΡΡΡ Π½Π° Π²ΠΈΠ²ΡΠ»ΡΠ½Π΅Π½Π½Ρ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΡΠ° ΠΎΠΏΡΠΈΠΌΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠΌΠΎΠ²ΠΈ ΠΏΡΠΎΠ±ΠΎΠΏΡΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ.ΠΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π²Π°Π»ΡΠΏΡΠΎΠ΅Π²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ 3-(2'-Π±ΡΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ»)-7-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΡΠΌΠ°ΡΠΈΠ½ΠΎΠΌ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ΠΎ Π΅Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π² ΠΊΡΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π΅ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π½Π° Π²ΡΡ
ΠΎΠ΄Ρ Π²Π°Π»ΡΠΏΡΠΎΠ΅Π²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΏΡΠΎΠ±ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ.The interaction of the valproic acid with 3-(2'-bromoacetyl)-7-methoxicoumarin has been carried out and its determination in blood by the reaction high performance liquid chromatography method has been developed. The influence of various methods of deproteinization on the yields of the valproic acid has been studied and the conditions of the sample preparing has been optimized
Prognostic Value of Colonic Tissue and Blood Eosinophils in Ulcerative Colitis.
BACKGROUND
It has been suggested that eosinophils may be a prognostic marker of disease outcome in ulcerative colitis (UC), but conflicting data exist. The objective was to investigate the extent of mucosal eosinophils and peripheral blood eosinophil count in newly diagnosed UC patients and to investigate its predictive value in short- and long-term disease outcomes.
METHODS
The degree of eosinophilia in baseline colonic biopsies and blood of newly diagnosed UC patients was retrospectively analyzed. It was investigated if tissue and blood eosinophilia could be a marker of a severe phenotype of UC, defined as the need for corticosteroids or immunomodulators in the first year or treatment with therapeutic monoclonal antibodies or colectomy during follow-up. Time to therapeutic monoclonal antibodies and time to colectomy were also evaluated as outcomes.
RESULTS
There were 103 UC patients (median age 26 years) included. Median tissue peak eosinophil count (PEC) was 70.0 and median peripheral blood eosinophil count was 0.3β
Γβ
109/L at diagnosis. Tissue PEC (rβ
=β
-0.161, P = .104) and blood eosinophil count (rβ
=β
0.022, P = .877) were not correlated with the severity of histologic inflammation. Logistic regression analyses did not identify PEC and blood eosinophil count as predictors of more severe disease outcomes. Tissue PEC and peripheral blood eosinophil count did not predict the time the initiation of therapeutic monoclonal antibodies or colectomy.
CONCLUSION
Baseline tissue or peripheral blood eosinophils are not markers of disease activity and cannot be used as a predictor of severe disease outcomes in both adults and children with UC
ΠΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π³Π΅ΡΡΠ°Π³Π΅Π½/ΡΡΡΡΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π³ΠΈΠΏΠ΅ΡΠ°Π½Π΄ΡΠΎΠ³Π΅Π½ΠΈΠΈ
Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³Π΅ΡΡΠ°Π³Π΅Π½/ΡΡΡΡΠΎΠ³Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π³ΠΈΠΏΠ΅ΡΠ°Π½Π΄ΡΠΎΠ³Π΅Π½ΠΈΠΈ. ΠΠΏΠΈΡΠ°Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Π΄ΡΠΎΡΠΏΠΈΡΠ΅Π½ΠΎΠ½Π° Ρ ΡΡΠΈΠ½ΠΈΠ΄ΡΡΡΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠΌ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π°ΠΊΠ½Π΅, ΡΠ΅Π±ΠΎΡΠ΅ΠΈ ΠΈ Π³ΠΈΡΡΡΡΠΈΠ·ΠΌΠ° Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π½ΡΠΆΠ΄Π°ΡΡΠΈΡ
ΡΡ Π² ΠΊΠΎΠ½ΡΡΠ°ΡΠ΅ΠΏΡΠΈΠΈ.The biochemical mechanisms of action of gestagen/estrogen drugs in treatment for syndrome of hyperandrogeny are featured. The advantages of Drospirenon and Etinidestradiol combination in treatment of acne, seborrhea and hirsutism in women simultaneously requiring contraception are described
The Habitual Diet of Dutch Adult Patients with Eosinophilic Esophagitis Has Pro-Inflammatory Properties and Low Diet Quality Scores
We determined the nutritional adequacy and overall quality of the diets of adult patients with eosinophilic esophagitis (EoE). Dietary intakes stratified by sex and age were compared to Dietary Reference Values (DRV). Overall diet quality was assessed by two independent Diet-Quality-Indices scores, the PANDiet and DHD-index, and compared to age- and gender-matched subjects from the general population. Lastly, food and nutrient intakes of EoE patients were compared to intakes of the general population. Saturated fat intake was significantly higher and dietary fiber intake significantly lower than the DRV in both males and females. In males, the DRV were not reached for potassium, magnesium, selenium, and vitamins A and D. In females, the DRV were not reached for iron, sodium, potassium, selenium, and vitamins A, B2, C and D. EoE patients had a significantly lower PANDiet and DHD-index compared to the general population, although the relative intake (per 1000 kcal) of vegetables/fruits/olives was significantly higher (yet still up to 65% below the recommended daily amounts) and alcohol intake was significantly lower compared to the general Dutch population. In conclusion, the composition of the habitual diet of adult EoE patients has several pro-inflammatory and thus unfavorable immunomodulatory properties, just as the general Dutch population, and EoE patients had lower overall diet quality scores than the general population. Due to the observational character of this study, further research is needed to explore whether this contributes to the development and progression of EoE
European Guideline on Achalasia - UEG and ESNM recommendations
Altres ajuts: These guidelines have been developed and funded within the United European Gastroenterology.Achalasia is a primary motor disorder of the oesophagus characterised by absence of peristalsis and insufficient lower oesophageal sphincter relaxation. With new advances and developments in achalasia management, there is an increasing demand for comprehensive evidence-based guidelines to assist clinicians in achalasia patient care. Guidelines were established by a working group of representatives from United European Gastroenterology, European Society of Neurogastroenterology and Motility, European Society of Gastrointestinal and Abdominal Radiology, and the European Association of Endoscopic Surgery in accordance with the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. A systematic review of the literature was performed and the certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Recommendations were voted upon using a nominal group technique. These guidelines focus on the definition of achalasia, treatment aims, diagnostic tests, medical, endoscopic and surgical therapy, management of treatment failure, follow-up and oesophageal cancer risk. These multidisciplinary guidelines provide a comprehensive evidence-based framework with recommendations on the diagnosis, treatment and follow-up of adult achalasia patients
Returning genome sequences to research participants:Policy and practice
Despite advances in genomic science stimulating an explosion of literature around returning health-related findings, the possibility of returning entire genome sequences to individual research participants has not been widely considered. Through direct involvement in large-scale translational genomics studies, we have identified a number of logistical challenges that would need to be overcome prior to returning individual genome sequence data, including verifying that the data belong to the requestor and providing appropriate informatics support. In addition, we identify a number of ethico-legal issues that require careful consideration, including returning data to family members, mitigating against unintended consequences, and ensuring appropriate governance. Finally, recognising that there is an opportunity cost to addressing these issues, we make some specific pragmatic suggestions for studies that are considering whether to share individual genomic datasets with individual study participants. If data are shared, research should be undertaken into the personal, familial and societal impact of receiving individual genome sequence data
Objectively diagnosing rumination syndrome in children using esophageal pH-impedance and manometry
This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'.
Β© 2017 John Wiley & Sons, Inc. All rights reserved.Background
Rumination syndrome is characterized by recurrent regurgitation of recently ingested food into the mouth. Differentiation with other diagnoses and gastroesophageal reflux disease (GERD) in particular, is difficult. Recently, objective pHβimpedance (pHβMII) and manometry criteria were proposed for adults. The aim of this study was to determine diagnostic ambulatory pHβMII and manometry criteria for rumination syndrome in children.
Methods
Clinical data and 24βhour pHβMII and manometry recordings of children with a clinical suspicion of rumination syndrome were reviewed. Recordings were analyzed for retrograde bolus flow extending into the proximal esophagus. Peak gastric and intraesophageal pressures closely related to these events were recorded and checked for a pattern compatible with rumination. Events were classified into primary, secondary, and supragastric belchβassociated rumination.
Key Results
Twentyβfive consecutive patients (11 males, median age 13.3 years [IQR 5.9β15.8]) were included; recordings of 18 patients were suitable for analysis. Rumination events were identified in 16/18 patients, with 50% of events occurring 30 mmHg, while only 50% of all events was characterized by peaks >30 mmHg and an additional 20% by peaks >25 mmHg. Four patients had evidence of acid GERD, all showing secondary rumination.
Conclusions and Inferences
Combined 24βhour pHβMII and manometry can be used to diagnose rumination syndrome in children and to distinguish it from GERD. Rumination patterns in children are similar compared with adults, albeit with lower gastric pressure increase. We propose a diagnostic cutoff for gastric pressure increase >25 mmHg associated with retrograde bolus flow into the proximal esophagus
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