An engineering approach to the use of expert systems technology in avionics applications

The concept of using a knowledge compiler to transform the knowledge base and inference mechanism of an expert system into a conventional program is presented. The need to accommodate real-time systems requirements in applications such as embedded avionics is outlined. Expert systems and a brief comparison of expert systems and conventional programs are reviewed. Avionics applications of expert systems are discussed before the discussions of applying the proposed concept to example systems using forward and backward chaining

Identification of novel small molecules that elevate Klotho expression

The absence of Klotho (KL) from mice causes the development of disorders associated with human aging and decreased longevity, whereas increased expression prolongs lifespan. With age, KL protein levels decrease, and keeping levels consistent may promote healthier aging and be disease-modifying. Using the KL promoter to drive expression of luciferase, we conducted a high-throughput screen to identify compounds that activate KL transcription. Hits were identified as compounds that elevated luciferase expression at least 30%. Following validation for dose-dependent activation and lack of cytotoxicity, hit compounds were evaluated further in vitro by incubation with opossum kidney and Z310 rat choroid plexus cells, which express KL endogenously. All compounds elevated KL protein compared with control. To determine whether increased protein resulted in an in vitro functional change, we assayed FGF23 (fibroblast growth factor 23) signalling. Compounds G–I augmented ERK (extracellular-signal-regulated kinase) phosphorylation in FGFR (fibroblast growth factor receptor)-transfected cells, whereas co-transfection with KL siRNA (small interfering RNA) blocked the effect. These compounds will be useful tools to allow insight into the mechanisms of KL regulation. Further optimization will provide pharmacological tools for in vivo studies of KL

Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

Influenza A virus (IAV) is among the most common causes of pneumonia-related death worldwide. Pulmonary epithelial cells are the primary target for viral infection and replication and respond by releasing inflammatory mediators that recruit immune cells to mount the host response. Severe lung injury and death during IAV infection result from an exuberant host inflammatory response. The linear ubiquitin assembly complex (LUBAC), composed of SHARPIN, HOIL-1L, and HOIP, is a critical regulator of NF-κB–dependent inflammation. Using mice with lung epithelial–specific deletions of HOIL-1L or HOIP in a model of IAV infection, we provided evidence that, while a reduction in the inflammatory response was beneficial, ablation of the LUBAC-dependent lung epithelial–driven response worsened lung injury and increased mortality. Moreover, we described a mechanism for the upregulation of HOIL-1L in infected and noninfected cells triggered by the activation of type I IFN receptor and mediated by IRF1, which was maladaptive and contributed to hyperinflammation. Thus, we propose that lung epithelial LUBAC acts as a molecular rheostat that could be selectively targeted to modulate the immune response in patients with severe IAV-induced pneumonia.Fil: Brazee, Patricia L.. Northwestern University; Estados UnidosFil: Morales Nebreda, Luisa. Northwestern University; Estados UnidosFil: Magnani, Natalia Daniela. Northwestern University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Garcia, Joe G. N.. University of Arizona; Estados UnidosFil: Misharin, Alexander V.. Northwestern University; Estados UnidosFil: Ridge, Karen M.. Northwestern University; Estados UnidosFil: Budinger, G.R. Scott. Northwestern University; Estados UnidosFil: Iwai, Kazuhiro. Kyoto University; JapónFil: Dada, Laura Andrea. Northwestern University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Sznajder, Jacob I.. Northwestern University; Estados Unido

Fruit crops, 1980: a summary of research

Performance of selected apple cultivars on semi-standard rootstocks in southern Ohio / David C. Ferree, Donald A. Chandler, and John C. Schmid -- Influence of summer pruning and alar on growth, flowering, and fruit set of Jerseymac apple trees / D. C. Ferree and E. J. Stang -- Influence of promalin on Delicious in Ohio / D. C. Ferree, E. J. Stang and R. C. Funt -- The effects of overtree misting for bloom delay on soil water status, net photosynthesis, transpiration, and carbohydrate levels of apple trees / R. M. Crassweller and D. C. Ferree -- Effect of orchard heaters on vertical temperature profiles / R. D. Fox, R. D. Brazee, and D. C. Ferree -- The effect of orchard heaters on air movement and temperature / R. D. Fox, R. D. Brazee, and D. C. Ferree -- Organotins and mite control on apples in Ohio / Franklin R. Hall -- Model of the air sprayer / R. D. Fox, R. D. Brazee, D. L. Reichard and F. R. Hall -- Effects of application equipment variables on spray deposition by orchard air sprayers / D. L. Reichard, F. R. Hall and H. R. Krueger -- Fungi associated with moldy-core of apple and their location within fruit / Michael A. Ellis -- Nutrient content of twelve french and american hybrid grape cultivars grown under a wide range of soil conditions / Garth A. Cahoo

Fruit crops, 1982: a summary of research

Influence of six rootstocks and herbicides on growth, cropping, and fruit quality of Blaxtayman apple trees / David C. Ferree and Robert G. Hill, Jr. -- Tree performance and yield efficiency of several apple cultivars on M9 and M9 interstems / D. C. Ferree -- Chemical induction of lateral shoots on young apple trees / S. C. Myers and D. C. Ferree -- The influence of urea sprays, mulch, and pruning on apple tree decline / G. A. Cahoon and C. W. Donoho, Jr. -- Influence of fireblight and ambrosia beetle on several apple cultivars on M9 and M9 interstems / F. R. Hall, M. A. Ellis, and D. C. Ferree -- A model study of the effect of wind on air sprayer jets / R. D. Fox, D. L. Reichard, and R. D. Brazee -- A comparative study of selected vineyard training and pruning systems for 'Concord' grapevines / G. A. Cahoon -- Effects of selected soil applied herbicides on grapes / Jomo MacDermot and Garth A. Cahoon -- Evaluation of aromatic compounds and virgin females as attractants for rose chafer / Roger N. Williams, Terrence P. McGovern, and Michael Klein -- Botrytis cinerea "gray mold" isolates from strawberry resistant to benlate in Ohio / P. Tanboon-Ek and M. A. Elli

Fruit crops 1990: a summary of research

Orchard temperature profiles in spring frost conditions / R. D. Brazee, R. D. Fox and D. C. Ferree -- Orchard sprayers: how much spray moves out of the orchard? / R. D. Fox, D. L. Reichard, R. D. Brazee, and F. R. Hall -- Influence of pruning treatments on mature spur-bound 'Starkrimson Delicious' apple trees / D. C. Ferree, J. C. Schmid, J. R. Schupp and I. J. Warrington -- The winter of 1983-84: a test winter for Ohio's fruit crops / C. K. Chandler and D. C. Ferree -- Performance of apple roostock, cultivars and cultural treatments under the stress of the 1988 drought / D. C. Ferree and J. C. Schmid -- Performance of a spur and standard Delicious strain in a slender spindle system / D. C. Ferree and J. C. Schmid -- Survey of Ohio strawberry growers: present practice and future directions / J. C. Scheerens and G. L. Brenneman -- Orchard crop loss assessments: a precondition for improved crop protection decisions / F. R. Hall -- Evaluation of compounds for control of foliar grape phylloxera, Daktulosphaira vitifoliae (Fitch) in Ohio / M. J. McLeod and R. N. Williams -- Marketing Ohio Strawberries / W. T. Rhodus and R. C. Fun

Fruit crops, 1986: a summary of research

Influence of treatments at planting on trellised apple tree performance / David C. Ferree -- Influence of growth regulators on branching of young apple trees / David C. Ferree and John C. Schmid -- Influence of growth regulators on scarf skin of Rome Beauty apples / David C. Ferree and John C. Schmid -- Influence of fungicides on scarf skin on Gallia Beauty / David C. Ferree and Michael A. Ellis -- Little relationship between root pruning and winter injury / James R. Schupp and David C. Ferree -- Performance of two apple cultivars on MS and M9 interstems on Antonovka / D. C. Ferree, R. M. McConnell, and J. C. Schmid -- Air sprayer jet deflection by travel or wind: as predicted by computer / R. D. Fox, R. D. Brazee, and D. L. Reichard -- Measuring atmospheric water vapor / R. D. Brazee and R. D. Fox -- A prototypic pollination unit made from expanded polystyrene / James E. Tew and Dewey M. Caron -- Effects of gibberellic acid (GA3) and daminozide (Alar) on growth and fruiting of Himrod grapes / G. A. Cahoon, M. L. Kaps, and S. P. Pathak -- Development of an action threshold for meadow spittlebug on strawberries / Mark A. Zajac and Franklin R. Hall -- Long-term yield of selected blackberry cultivars and selections in southern Ohio / Craig K. Chandler, Donald A. Chandler, and Greg L. Brenneman -- Electronic information transfer / R. C. Funt. -- A summary of research on synthetic pyrethroids and mites in the apple orchard ecosystem / Franklin R. Hall -- Controlling apple collar rot: effects of fungicides, soil amendments, and depth of planting / M. A. Ellis, D. C. Ferree, and L. V. Madden -- Validation of an electronic unit for predicting apple scab infection periods / M. A. Ellis, L. V. Madden, and L. L. Wilson -- Epidemiology and control of strawberry leather rot / G. G. Grove, M. A. Ellis, and L. V. Madden -- Research on cane diseases of thornless blackberry in Ohio / M. A. Ellis, G. A. Kuter, and L. L. Wilso

Fruit crops 1994: a summary of research

Effects of nitrogen fertilization on total yield, different yield components, and foliar levels of 'Heritage' raspberry / D. R. Baral, G. A. Cahoon -- Influence of training stakes and various pruning and bending techniques on early performance of 'Fuji' apple trees / D. C. Ferree, J. C. Schmid -- Pilot project for integrated pest management in Ohio apple orchards / C. Welty -- Relationship of canopy micro-climate and apple tree fruit and leaf performance / D. Ferree, J. Tew, D. Miller, R. Brazee, R. Fox -- Effect of root pruning on shoot tip ethylene production and xylem concentrations of cytokinln and 1-aminocyclopropane-1-carboxylic acid in young apple trees / J. R. Schupp, D. C. Ferree -- Rootstock effects on spur characteristics, spur leaf nitrogen content and early production of apple trees / M. Rottgerman, D. Ferree, J. Schmid -- Inhibition of growth of crown-gall-causing bacteria (Agrobacterium tumefaciens) by polyamine synthesis inhibitors / T. Ponappa, A. R. Miller -- Relationships among apple weight, seed number, seed weight, germination date and apple seedling vigor / D. D. Miller, K. Kaiser -- Evaluation of organic and conventional fungicide programs for control of apple scab in Ohio / M. A. Ellis, L. V. Madden, L. L. Wilson, D. C. Ferree -- Evaluation of commercially available serological test kits for diagnosis of apple crown and root rot caused by Phytophthora spp in Ohio / M. A. Ellis, S. A. Miller -- A survey of the pest management practices, information sources, needs, and decision making criteria of Ohio apple growers / F. A. Hale, F. R. Hall -- Effects of cultural systems on the horticultural performance and fruit quality of strawberries / J. C. Scheerens, G. L. Brenneman -- Performance of new or uncommon strawberry cultivars grown under Ohio cultural conditions / G. L. Brenneman, J. C. Scheerens -- A comparison of spray drift deposited on ground and airborne spray collectors and on soybean plants / R. D. Fox, S. M. Hussein, D. L. Reichard, R. D. Brazee, F. R. Hall -- Experimental vs. computer-predicted air velocities for a cross-flow sprayer / R. D. Fox, R. D. Brazee, S. A. Svensson, D. L. Reichar