7,299 research outputs found
The Convective Urca Process with Implicit Two-Dimensional Hydrodynamics
Consideration of the role of the convective flux in the thermodymics of the
convective Urca neutrino loss process in degenerate, convective, quasi-static,
carbon-burning cores shows that the convective Urca process slows down the
convective current around the Urca-shell, but, unlike the "thermal" Urca
process, does not reduce the entropy or temperature for a given convective
volume. Here we demonstrate these effects with two-dimensional numerical
hydrodynamical calculations. These two-dimensional implicit hydrodynamics
calculations invoke an artificial speeding up of the nuclear and weak rates.
They should thus be regarded as indicative, but still qualitative. We find
that, compared to a case with no Urca-active nuclei, the case with Urca effects
leads to a higher entropy in the convective core because the energy released by
nuclear burning is confined to a smaller volume by the effective boundary at
the Urca shell. All else being equal, this will tend to accelerate the
progression to dynamical runaway. We discuss the open issues regarding the
impact of the convective Urca process on the evolution to the "smoldering
phase" and then to dynamical runaway.Comment: 22 pages, 11 figures, accepted for publication in the Astrophysical
Journa
Bioconversion of polyphenols and organic acids by gut microbiota of predigested Hibiscus sabdariffa L. calyces and Agave (A. tequilana Weber) fructans assessed in a dynamic in vitro model (TIM-2) of the human colon
The present work aimed at understanding gut microbiota bioconversion of phenolic compounds (PC) and organic acids in predigested Hibiscus sabdariffa (Hb) calyces and the mixture of Hb and Agave (Agave tequilana Weber) fructans (AF). With this purpose, dried Hb and Hb/AF were predigested with enzymatic treatment, and then fermented in a dynamic in vitro model of the human colon (TIM-2). After HPLC-ESI-QToF-MS analysis of samples taken at 0, 24, 48 and 72 h of fermentation, it was observed that hydroxycinnamic acids, flavanols, flavonols, and anthocyanins were mainly transformed into derivatives of hydroxyphenylpropionic, hydroxyphenylacetic and hydroxybenzoic acids. Moreover, organic acids, such as hydroxycitric and hibiscus acids, were formed along with unidentified lactones and reduced compounds. Interestingly, no differences were observed between microbial-derived metabolites formed after the fermentation of Hb and Hb/AF. In conclusion, colonic fermentation of polyphenol-rich Hb yields a wide range of microbial phenolic metabolites with potential effects on health.RMB and SGSA acknowledge to Science and Technology for Development Program (CYTED) through the Ibero-American Network of Underutilized Autonomous Foods (ALSUB-CYTED, 118RT0543). SGSA acknowledges CONACYT-Mexico for the sabbatical grant 260935. The Spanish Ministry of Science, Innovation and Universities (Project AGL2015-69986-R) is also acknowledged. This research has been made possible with the support of the Dutch Province of Limburg.Peer reviewe
Motivic Serre invariants, ramification, and the analytic Milnor fiber
We show how formal and rigid geometry can be used in the theory of complex
singularities, and in particular in the study of the Milnor fibration and the
motivic zeta function. We introduce the so-called analytic Milnor fiber
associated to the germ of a morphism f from a smooth complex algebraic variety
X to the affine line. This analytic Milnor fiber is a smooth rigid variety over
the field of Laurent series C((t)). Its etale cohomology coincides with the
singular cohomology of the classical topological Milnor fiber of f; the
monodromy transformation is given by the Galois action. Moreover, the points on
the analytic Milnor fiber are closely related to the motivic zeta function of
f, and the arc space of X.
We show how the motivic zeta function can be recovered as some kind of Weil
zeta function of the formal completion of X along the special fiber of f, and
we establish a corresponding Grothendieck trace formula, which relates, in
particular, the rational points on the analytic Milnor fiber over finite
extensions of C((t)), to the Galois action on its etale cohomology.
The general observation is that the arithmetic properties of the analytic
Milnor fiber reflect the structure of the singularity of the germ f.Comment: Some minor errors corrected. The original publication is available at
http://www.springerlink.co
Advanced practice in radiotherapy across Europe: stakeholders’ perceptions of implementation and evolution
Introduction Adapting radiotherapy services with workforce innovation using skills-mix or task-shifting optimises resources, supporting current and future demands. Advanced practitioners (APs) work at a different level of practice (beyond initial registration) across four pillars: clinical practice, leadership and management, education, and research. There is limited cross-country research on the advanced therapeutic radiographers/radiation therapists (TR/RTTs), particularly in Europe. This study aimed to investigate European radiotherapy stakeholders’ perceptions regarding current and future advanced practice (AP). Methods From June to September 2022, one-to-one online semi-structured interviews were conducted in English, and audio and video were recorded. Full verbatim audio files were independently transcribed and checked by interviewer and interviewees. Braun and Clarke's seven steps guided the thematic analysis (using NVivo). Results Thirty-three interviewees working or studying in 16 European countries represented practitioners (n=14), managers (n=6), educators (n=4), professional bodies (n=4), students (n=3), and regulators (n=2). Four overarching themes emerged: “AP drivers and outcomes”, “AP challenges vs enablers”, “Current vs future AP”, “Becoming and being advanced practitioner”. Participants identified research as the neglected AP pillar due to a lack of protected time, limited staff skills, no research culture, no funding, workload, and clinical priorities. Interviewees highlighted the importance of consistency in job titles, harmonisation of education models and curricula, definition of AP requirements, and support for all AP pillars through job plans and workforce planning. Conclusion Neither the profession nor education of TR/RTTs are harmonised across Europe, which is highly reflected in advanced-level practice. Advanced TR/RTTs should work across all pillars, including research, and these should be embedded in master's programmes, including leadership. Implications for practice This study highlights a policy gap in the education and practice of APs in radiotherapy
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