EXPLOSIVE CYCLOGENESIS OVER THE SOUTH-EASTERN ROMANIA DECEMBER 2 – 3, 2012

Explosive cyclogenesis over the south-eastern Romania december 2-3, 2012 . This paper is devoted to the study of the synoptic- dynamical conditions that contributed to the development of an rare explosive cyclogenesis event occurred at the beginning of 2012-2013 winter in southwestern Romania, more precisely between 2nd and 3th of December, 2012. The minimum pressure observed was 980,2 hPa, the lowest ever observed record in the surface of Sulina observation station, and also over the western side of Black Sea during period 1961-2000 and 1965-2004. It was found that the cyclone was not a regular one, but a real „meteorological bomb” one where the central pressure at sea level has recorded an important decrease at about 32,3 hPa in 24 hours, equivalent with 1,7 Bergeron. Comparative by „XX century storms” Lothar and Martin (level 2 and 1 on hurricane scale) which desolated western and central Europe in December 1999, this case of explosive cyclogenesis can be considered one of the extreme for our area concerning both meteorological view as well as the effects

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives

A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied. Five of them were selected, conventionally named S1, S2, S3, S4, S5, and investigated in terms of their potential influence on the central nervous system (CNS). For this purpose, the antidepressant effect was determined using the forced swimming test; the anxiolytic/ anxiogenic effect was determined using the suspended plus-shaped maze (Ugo Basile); the effect on the motor activity was determined using the Ugo Basile activity cage; and the potential analgesic effect was investigated using the hot plate test (Ugo Basile). Compounds S3 and S5 lowered the motor activity and showed an anxiolytic effect, while S1 and S2 proved to have antidepressant and analgesic effects. A good correlation between antidepressant and analgesic effects was observed, consistent with the fact that analgesic drugs, by increasing norepinephrine and serotonin levels in the pain inhibiting descendent pathways, can be used as co-analgesics in therapy

Coordinating negotiations in data-intensive collaborative working environments using an agent-based model-driven platform

This paper tackles the interoperability problems of enterprise information systems by presenting a distributive model-driven platform for parallel coordination of multiple negotiations in data-intensive collaborative working environments. The proposed model was validated and verified by an industrial application scenario within the European research project H2020 C2NET (Cloud Collaborative Manufacturing Networks). This real scenario developed data-intensive collaborative and cloud-enabled tools that allow the optimisation of the supply network of manufacturing SMEs, proposing a negotiation solution based on a model-driven interoperable decentralised architecture.info:eu-repo/semantics/acceptedVersio

Solving airline operations problems using specialized agents in a distributed multi-agent system

An airline schedule very rarely operates as planned. Problems related with aircrafts, crew members and passengers are common and the actions towards the solution of these problems are usually known as operations recovery. The Airline Operations Control Center (AOCC) tries to solve these problems with the minimum cost and satisfying all the required rules. In this paper we present the implementation of a Distributed Multi-Agent System (MAS) representing the existing roles in an AOCC, This MAS deals with several operational bases and for each type of operation problems it has several specialized software agents that implement different algorithms (heuristic, AI, OR, etc.), competing to find the best solution for each problem. We present a real case study taken from an AOCC where a crew recovery problem is solved. Computational results using a real airline schedule are presented, including a comparison with a solution for the same problem found by the human operators in the AOCC. We show that, even in simple problems and when comparing with solutions found by human operators, it is possible to find valid solutions, in less time and with a smaller cost

Pheochromocytoma – clinical manifestations, diagnosis and current perioperative management

Pheochromocytoma is a neuroendocrine tumor characterized by the excessive production of catecholamines (epinephrine, norepinephrine, and dopamine). The diagnosis is suspected due to hypertensive paroxysms, associated with vegetative phenomena, due to the catecholaminergic hypersecretion. Diagnosis involves biochemical tests that reveal elevated levels of catecholamine metabolites (metanephrine and normetanephrine). Functional imaging, such as 123I-metaiodobenzylguanidine scintigraphy (123I-MIBG), has increased specificity in identifying the catecholamine-producing tumor and its metastases. The gold-standard treatment for patients with pheochromocytoma is represented by the surgical removal of the tumor. Before surgical resection, it is important to optimize blood pressure and intravascular volume in order to avoid negative hemodynamic events

A negotiation approach to support interoperability in a collaborative manufacturing environment

Maintaining the interoperability in a dynamic competitive manufacturing environment in which different business enterprises collaborate is difficult to achieve. Our approach highlights negotiation as the best solution to solve interoperability problems by reaching the common decision suitable for all managers of various enterprises in the most optimized amount of time. In this context, this paper proposes a multi-agent negotiation model, able to coordinate several negotiations taking place in parallel among multiple participants. It is described the negotiation strategy for evaluating and generating offers and the protocol for sending the offers to the other agents. This model is being implemented in the H2020 C2NET project for supporting manufacturing.info:eu-repo/semantics/acceptedVersio