Edge analytics in the internet of things

High-data-rate sensors are becoming ubiquitous in the Internet of Things. GigaSight is an Internet-scale repository of crowd-sourced video content that enforces privacy preferences and access controls. The architecture is a federated system of VM-based cloudlets that perform video analytics at the edge of the Internet

Variational quantum iterative power algorithms for global optimization

We introduce a family of variational quantum algorithms called quantum iterative power algorithms (QIPA) that outperform existing hybrid near-term quantum algorithms of the same kind. We demonstrate the capabilities of QIPA as applied to three different global-optimization numerical experiments: the ground-state optimization of the $H_2$ molecular dissociation, search of the transmon qubit ground-state, and biprime factorization. Since our algorithm is hybrid, quantum/classical technologies such as error mitigation and adaptive variational ansatzes can easily be incorporated into the algorithm. Due to the shallow quantum circuit requirements, we anticipate large-scale implementation and adoption of the proposed algorithm across current major quantum hardware.Comment: 17 pages, 7 figure

Review of Well-to-Wheel lifecycle emissions of liquefied natural gas heavy goods vehicles

It has been suggested that using liquefied natural gas as a fuel source for heavy goods vehicles could provide a reduction in greenhouse gas emissions. Various studies have investigated different aspects of the lifecycle emissions of natural gas heavy goods vehicles throughout the past decade, however, there has been little comparative analysis across these studies. This review provides a comprehensive examination of the well-to-wheel lifecycle emissions of liquefied natural gas for heavy goods vehicles in comparison to diesel, the current standard. A systematic selection criteria based on relevance to the defined well-to-wheel system boundary of liquefied natural gas as a fuel source for heavy goods vehicles, including greenhouse gas emissions, were augmented by the authors knowledge of the field. The various data are categorised by engine technology and model year (pre- and post-2015), average speed of the duty cycle, and then statistically analysed to identify clear trends and correlations in the emissions produced. The two primary factors affecting the well-to-wheel greenhouse gas emissions of natural gas heavy hoods vehicles are: (i) natural gas engine fuel efficiency relative to diesel, and (ii) methane leakage across the supply chain. Methane leakage rates are a significant uncertainty and range from 0.3 to 20 % of throughput. With long-term perspective of efficiency penalty (10 %) in natural gas engines, the well-to-wheel greenhouse gas emissions reduction of natural gas fuelled trucks against diesel is up to 10 %, which appears insufficient toward net zero emissions by 2050. The use of biomethane further reduces the greenhouse gas emissions by 34–66 % depending on the engine technology. Controlling fugitive methane emissions in the fuel production and supply chain remains critical

Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction

<p>Abstract</p> <p>Background</p> <p>PKA is a ubiquitous, multi-subunit cellular kinase that regulates a number of different physiological responses in response to cAMP, including metabolism, cell division, and cardiac function. Numerous studies have implicated altered PKA signaling in cardiac dysfunction. Recently, it has been shown that mice lacking the catalytic β subunit of PKA (PKA Cβ) are protected from age-related problems such as weight gain and enlarged livers, and we hypothesized that these mice might also be resistant to cardiomyopathy.</p> <p>Findings</p> <p>Angiotensin II (ang II) induced hypertension in both PKA Cβ null mice and their WT littermates. However, PKA Cβ null mice were resistant to a number of ang II-induced, cardiopathological effects observed in the WT mice, including hypertrophy, decreased diastolic performance, and enlarged left atria.</p> <p>Conclusion</p> <p>The Cβ subunit of PKA plays an important role in angiotensin-induced cardiac dysfunction. The Cβ null mouse highlights the potential of the PKA Cβ subunit as a pharmaceutical target for hypertrophic cardiac disease.</p

Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

Serologic studies are an important diagnostic tool in the clinical evaluation and follow-up of persons with coccidioidomycosis. Numerous types of serologic tests are available, including immunodiffusion, enzyme immunoassay, and complement fixation. We conducted a retrospective review of the results of 1,797 serologic tests spanning 12 months from the onset of coccidioidomycosis in 298 immunocompetent and 62 immunosuppressed persons with symptomatic infection. Using the onset of symptoms as a reference point, we plotted the positive or negative serologic results over time for both groups. Compared with the immunocompetent group, immunosuppressed persons had lower rates of seropositivity for every type of test during the first year after onset of symptoms for coccidioidomycosis, although many results did not achieve statistical significance. Combining the results of these tests increased the sensitivity of the serologic evaluation in immunocompromised patients. Immunosuppressed persons have the ability to mount a serologic response to coccidioidomycosis, but in some circumstances, multiple methods may be required to improve detection

Shedding New Light on Weak Emission-Line Quasars in the CIV_{\rm IV}-Hβ\beta Parameter Space

Weak emission-line quasars (WLQs) are a subset of Type 1 quasars that exhibit extremely weak Ly$\alpha +$N V $\lambda$1240 and/or C IV $\lambda$1549 emission lines. We investigate the relationship between emission-line properties and accretion rate for a sample of 230 `ordinary' Type 1 quasars and 18 WLQs at $z < 0.5$ and $1.5 < z < 3.5$ that have rest-frame ultraviolet and optical spectral measurements. We apply a correction to the H$\beta$-based black-hole mass ($M_{\rm BH}$) estimates of these quasars using the strength of the optical Fe II emission. We confirm previous findings that WLQs' $M_{\rm BH}$ values are overestimated by up to an order of magnitude using the traditional broad emission-line region size-luminosity relation. With this $M_{\rm BH}$ correction, we find a significant correlation between H$\beta$-based Eddington luminosity ratios and a combination of the rest-frame C IV equivalent width and C IV blueshift with respect to the systemic redshift. This correlation holds for both ordinary quasars and WLQs, which suggests that the two-dimensional C IV parameter space can serve as an indicator of accretion rate in all Type 1 quasars across a wide range of spectral properties.Comment: 17 pages (AASTeX 6.3.1), 5 figures, accepted for publication in Ap

Involving Citizen Scientists in Biodiversity Observation

The involvement of non-professionals in scientific research and environmental monitoring, termed Citizen Science (CS), has now become a mainstream approach for collecting data on earth processes, ecosystems and biodiversity. This chapter examines how CS might contribute to ongoing efforts in biodiversity monitoring, enhancing observation and recording of key species and systems in a standardised manner, thereby supporting data relevant to the Essential Biodiversity Variables (EBVs), as well as reaching key constituencies who would benefit Biodiversity Observation Networks (BONs). The design of successful monitoring or observation networks that rely on citizen observers requires a careful balancing of the two primary user groups, namely data users and data contributors (i.e., citizen scientists). To this end, this chapter identifies examples of successful CS programs as well as considering practical issues such as the reliability of the data, participant recruitment and motivation, and the use of emerging technologies

Difficulty Accessing Syringes Mediates the Relationship Between Methamphetamine Use and Syringe Sharing Among Young Injection Drug Users

Injection drug users (IDU) who use methamphetamine (MA) are at an increased risk of HIV infection due to engagement in injection-related risk behavior including syringe sharing. In this cohort study of young IDU aged 18-30, we investigated the relationship between injection MA use and syringe sharing, and whether difficulty accessing sterile syringes mediated this association. Behavioral questionnaires were completed by 384 IDU in Vancouver, Canada between October 2005 and May 2008. Generalized estimating equations were used to estimate direct and indirect effects. The median age of participants was 24 (IQR: 22–27) and 214 (55.7%) were male. Injecting MA was independently associated with syringe sharing. Mediation analyses revealed that difficulty accessing sterile syringes partially mediated the association between injecting MA and syringe sharing. Interventions to reduce syringe sharing among young methamphetamine injectors must address social and structural barriers to accessing HIV prevention programs

ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK

<p>Abstract</p> <p>Background</p> <p>Obesity is a health hazard which is closely associated with various complications including insulin resistance, hypertension, dyslipidemia, atherosclerosis, type 2 diabetes and cancer. In spite of numerous preclinical and clinical interventions, the prevalence of obesity and its related disorders are on the rise demanding an urgent need for exploring novel therapeutic agents that can regulate adipogenesis. In the present study, we evaluated whether a dietary supplement ReishiMax (RM), containing triterpenes and polysaccharides extracted from medicinal mushroom <it>Ganoderma lucidum</it>, affects adipocyte differentiation and glucose uptake in 3T3-L1 cells.</p> <p>Methods</p> <p>3T3-L1 pre-adipocytes were differentiated into adipocytes and treated with RM (0-300 μg/ml). Adipocyte differentiation/lipid uptake was evaluated by oil red O staining and triglyceride and glycerol concentrations were determined. Gene expression was evaluated by semi-quantitative RT-PCR and Western blot analysis. Glucose uptake was determined with [³H]-glucose.</p> <p>Results</p> <p>RM inhibited adipocyte differentiation through the suppresion of expression of adipogenic transcription factors peroxisome proliferator-activated receptor-γ (PPAR-γ), sterol regulatory element binding element protein-1c (SREBP-1c) and CCAAT/enhancer binding protein-α (C/EBP-α). RM also suppressed expression of enzymes and proteins responsible for lipid synthesis, transport and storage: fatty acid synthase (FAS), acyl-CoA synthetase-1 (ACS1), fatty acid binding protein-4 (FABP4), fatty acid transport protein-1 (FATP1) and perilipin. RM induced AMP-activated protein kinase (AMPK) and increased glucose uptake by adipocytes.</p> <p>Conclusion</p> <p>Our study suggests that RM can control adipocyte differentiation and glucose uptake. The health benefits of ReishiMax warrant further clinical studies.</p