214 research outputs found
A multidisciplinary review of the science of vitamin D receptor activation
Our understanding of the vitamin D receptor (VDR) and the effects of VDR activation has changed dramatically in recent years, with the publication of several new studies looking at selective VDR activation and effects on the cardio-renal syndrome (CRS).1 These advances have the potential to change the perspective of VDR activation beyond its role in mineral metabolism. Pleiotropic vitamin D effects have come into the focus of interest
Circulating markers of bone turnover
Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, quality or strength. Bone turnover can be considered to be primarily a reflection of bone cell activity, in particular that of osteoblasts and osteoclasts. Since current treatments for bone disease usually target cellular activity, biomarkers are considered to be able to contribute to the decision-making for treatment and its follow-up. In CKD, one has to consider the impact of a diminished clearance of biomarkers or their altered metabolism, both potentially limiting its clinical use. Here, several aspects of the most frequently used biomarkers of bone turnover are reviewed, with an emphasis on the specific situation represented by CKD. This review is based on the overview lecture at the symposium held in Amsterdam, September 23, 2016: "The Bone In CKD", organized by the CKD-MBD working group of ERA-EDTA
Measurements of the Production, Decay and Properties of the Top Quark: A Review
With the full Tevatron Run II and early LHC data samples, the opportunity for
furthering our understanding of the properties of the top quark has never been
more promising. Although the current knowledge of the top quark comes largely
from Tevatron measurements, the experiments at the LHC are poised to probe
top-quark production and decay in unprecedented regimes. Although no current
top quark measurements conclusively contradict predictions from the standard
model, the precision of most measurements remains statistically limited.
Additionally, some measurements, most notably the forward-backward asymmetry in
top quark pair production, show tantalizing hints of beyond-the-Standard-Model
dynamics. The top quark sample is growing rapidly at the LHC, with initial
results now public. This review examines the current status of top quark
measurements in the particular light of searching for evidence of new physics,
either through direct searches for beyond the standard model phenomena or
indirectly via precise measurements of standard model top quark properties
Search for anomalous top-gluon couplings at LHC revisited
Through top-quark pair productions at LHC, we study possible effects of
nonstandard top-gluon couplings yielded by SU(3)xSU(2)xU(1) invariant
dimension-6 effective operators. We calculate the total cross section and also
some distributions for p p -> t tbar X as functions of two anomalous-coupling
parameters, i.e., the chromoelectric and chromomagnetic moments of the top,
which are constrained by the total cross section sigma(p pbar -> t tbar X)
measured at Tevatron. We find that LHC might give us some chances to observe
sizable effects induced by those new couplings.Comment: One comment and related two refs. added. Final version (to appear in
Eur.Phys.J. C
Soft Photons in Hadron-Hadron Collisions: Synchrotron Radiation from the QCD Vacuum?
We discuss the production of soft photons in high energy hadron-hadron
collisions. We present a model where quarks and antiquarks in the hadrons emit
``synchrotron light'' when being deflected by the chromomagnetic fields of the
QCD vacuum, which we assume to have a nonperturbative structure. This gives a
source of prompt soft photons with frequencies in the c.m.
system of the collision in addition to hadronic bremsstrahlung. In comparing
the frequency spectrum and rate of ``synchrotron'' photons to experimental
results we find some supporting evidence for their existence. We make an
exclusive--inclusive connection argument to deduce from the ``synchrotron''
effect a behaviour of the neutron electric formfactor proportional
to for . We find this to be consistent with
available data. In our view, soft photon production in high energy
hadron-hadron and lepton-hadron collisions as well as the behaviour of
electromagnetic hadron formfactors for low are thus sensitive probes of
the nonperturbative structure of the QCD vacuum.Comment: Heidelberg preprint HD-THEP-94-36, 31 pages, LaTeX + ZJCITE.sty
(included), 12 figures appended as uuencoded compressed ps-fil
Nuclear effects in the Drell-Yan process at very high energies
We study Drell-Yan (DY) dilepton production in proton(deuterium)-nucleus and
in nucleus-nucleus collisions within the light-cone color dipole formalism.
This approach is especially suitable for predicting nuclear effects in the DY
cross section for heavy ion collisions, as it provides the impact parameter
dependence of nuclear shadowing and transverse momentum broadening, quantities
that are not available from the standard parton model. For p(D)+A collisions we
calculate nuclear shadowing and investigate nuclear modification of the DY
transverse momentum distribution at RHIC and LHC for kinematics corresponding
to coherence length much longer than the nuclear size. Calculations are
performed separately for transversely and longitudinally polarized DY photons,
and predictions are presented for the dilepton angular distribution.
Furthermore, we calculate nuclear broadening of the mean transverse momentum
squared of DY dileptons as function of the nuclear mass number and energy. We
also predict nuclear effects for the cross section of the DY process in heavy
ion collisions. We found a substantial nuclear shadowing for valence quarks,
stronger than for the sea.Comment: 46 pages, 18 figures, title changed and some discussion added,
accepted for publication in PR
The fully differential single-top-quark cross section in next-to-leading order QCD
We present a new next-to-leading order calculation for fully differential
single-top-quark final states. The calculation is performed using phase space
slicing and dipole subtraction methods. The results of the methods are found to
be in agreement. The dipole subtraction method calculation retains the full
spin dependence of the final state particles. We show a few numerical results
to illustrate the utility and consistency of the resulting computer
implementations.Comment: 37 pages, latex, 2 ps figure
The Top Quark Decay Vertex in Standard Model Extensions
New physics interactions can affect the strength and structure of the
vertex. We investigate the magnitudes and phases of "anomalous" contributions
to this vertex in a two-Higgs doublet and the minimal supersymmetric extension
of the standard model, and in a top-color assisted technicolor (TC2) model.
While the magnitudes of the anomalous couplings remain below 1 percent in the
first two models, TC2 interactions can reduce the left-chiral coupling by
several percent.Comment: Latex, 27 pages, 14 figure
Photospheric and Subphotospheric Dynamics of Emerging Magnetic Flux
Magnetic fields emerging from the Sun's interior carry information about
physical processes of magnetic field generation and transport in the convection
zone. Soon after appearance on the solar surface the magnetic flux gets
concentrated in sunspot regions and causes numerous active phenomena on the
Sun. This paper discusses some properties of the emerging magnetic flux
observed on the solar surface and in the interior. A statistical analysis of
variations of the tilt angle of bipolar magnetic regions during the emergence
shows that the systematic tilt with respect to the equator (the Joy's law) is
most likely established below the surface. However, no evidence of the
dependence of the tilt angle on the amount of emerging magnetic flux, predicted
by the rising magnetic flux rope theories, is found. Analysis of surface plasma
flows in a large emerging active region reveals strong localized upflows and
downflows at the initial phase of emergence but finds no evidence for
large-scale flows indicating future appearance a large-scale magnetic
structure. Local helioseismology provides important tools for mapping
perturbations of the wave speed and mass flows below the surface. Initial
results from SOHO/MDI and GONG reveal strong diverging flows during the flux
emergence, and also localized converging flows around stable sunspots. The wave
speed images obtained during the process of formation of a large active region,
NOAA 10488, indicate that the magnetic flux gets concentrated in strong field
structures just below the surface. Further studies of magnetic flux emergence
require systematic helioseismic observations from the ground and space, and
realistic MHD simulations of the subsurface dynamics.Comment: 21 pages, 15 figures, to appear in Space Science Review
Anti-Search for the Glueball Candidate f_J(2220) in Two-Photon Interactions
Using 13.3 fb^{-1} of e^+e^- data recorded with the CLEO II and CLEO II.V
detector configurations at CESR, we have searched for f_J(2220) decays to
K^0_{S} K^0_{S} in untagged two-photon interactions. We report an upper limit
on the product of the two-photon partial width and the branching fraction,
Gamma_gamma gamma cdot B (f_J(2220) to K^0_{S} K^0_{S}) of less than 1.1 eV at
the 95% C.L: systematic uncertainties are included. This dataset is four times
larger than that used in the previous CLEO publication.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, Submitted to PRD (R
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