High-Redshift Dust Obscured Galaxies: A Morphology-Spectral Energy Distribution Connection Revealed by Keck Adaptive Optics

A simple optical to mid-IR color selection, R – [24]>14, i.e., f_ν(24 μm)/f_ν(R) ≳ 1000, identifies highly dust obscured galaxies (DOGs) with typical redshifts of z ~ 2 ± 0.5. Extreme mid-IR luminosities (L_(IR) > 10^(12-14)) suggest that DOGs are powered by a combination of active galactic nuclei (AGNs) and star formation, possibly driven by mergers. In an effort to compare their photometric properties with their rest-frame optical morphologies, we obtained high-spatial resolution (0."05-0."1) Keck Adaptive Optics K'-band images of 15 DOGs. The images reveal a wide range of morphologies, including small exponential disks (eight of 15), small ellipticals (four of 15), and unresolved sources (two of 15). One particularly diffuse source could not be classified because of low signal-to-noise ratio. We find a statistically significant correlation between galaxy concentration and mid-IR luminosity, with the most luminous DOGs exhibiting higher concentration and smaller physical size. DOGs with high concentration also tend to have spectral energy distributions (SEDs) suggestive of AGN activity. Thus, central AGN light may be biasing the morphologies of the more luminous DOGs to higher concentration. Conversely, more diffuse DOGs tend to show an SED shape suggestive of star formation. Two of 15 in the sample show multiple resolved components with separations of ~1 kpc, circumstantial evidence for ongoing mergers

The Popeye Domain Containing Genes and Their Function in Striated Muscle

The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins is rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (Dystrophin), compartmentalization (Caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (Dysferlin), or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggests that this family of cAMP-binding proteins probably serves multiple roles in striated muscle

An Observational Limit on the Dwarf Galaxy Population of the Local Group

We present the results of an all-sky, deep optical survey for faint Local Group dwarf galaxies. Candidate objects were selected from the second Palomar survey (POSS-II) and ESO/SRC survey plates and follow-up observations performed to determine whether they were indeed overlooked members of the Local Group. Only two galaxies (Antlia and Cetus) were discovered this way out of 206 candidates. Based on internal and external comparisons, we estimate that our visual survey is more than 77% complete for objects larger than one arc minute in size and with a surface brightness greater than an extremely faint limit over the 72% of the sky not obstructed by the Milky Way. Our limit of sensitivity cannot be calculated exactly, but is certainly fainter than 25 magnitudes per square arc second in R, probably 25.5 and possibly approaching 26. We conclude that there are at most one or two Local Group dwarf galaxies fitting our observational criteria still undiscovered in the clear part of the sky, and a roughly a dozen hidden behind the Milky Way. Our work places the "missing satellite problem" on a firm quantitative observational basis. We present detailed data on all our candidates, including surface brightness measurements.Comment: 58 pages in AJ manuscript format; some figures at slightly reduced quality; accepted by the Astronomical Journa

Svortices and the fundamental modes of the "snake instability": Possibility of observation in the gaseous Bose-Einstein Condensate

The connection between quantized vortices and dark solitons in a long and thin, waveguide-like trap geometry is explored in the framework of the non-linear Schr\"odinger equation. Variation of the transverse confinement leads from the quasi-1D regime where solitons are stable to 2D (or 3D) confinement where soliton stripes are subject to a transverse modulational instability known as the ``snake instability''. We present numerical evidence of a regime of intermediate confinement where solitons decay into single, deformed vortices with solitonic properties, also called svortices, rather than vortex pairs as associated with the ``snake'' metaphor. Further relaxing the transverse confinement leads to production of 2 and then 3 vortices, which correlates perfectly with a Bogoliubov-de Gennes stability analysis. The decay of a stationary dark soliton (or, planar node) into a single svortex is predicted to be experimentally observable in a 3D harmonically confined dilute gas Bose-Einstein condensate.Comment: 4 pages, 4 figure

Morphologies of High Redshift, Dust Obscured Galaxies from Keck Laser Guide Star Adaptive Optics

Spitzer MIPS images in the Bootes field of the NOAO Deep Wide-Field Survey have revealed a class of extremely dust obscured galaxy (DOG) at z~2. The DOGs are defined by very red optical to mid-IR (observed-frame) colors, R - [24 um] > 14 mag, i.e. f_v (24 um) / f_v (R) > 1000. They are Ultra-Luminous Infrared Galaxies with L_8-1000 um > 10^12 -10^14 L_sun, but typically have very faint optical (rest-frame UV) fluxes. We imaged three DOGs with the Keck Laser Guide Star Adaptive Optics (LGSAO) system, obtaining ~0.06'' resolution in the K'-band. One system was dominated by a point source, while the other two were clearly resolved. Of the resolved sources, one can be modeled as a exponential disk system. The other is consistent with a de Vaucouleurs profile typical of elliptical galaxies. The non-parametric measures of their concentration and asymmetry, show the DOGs to be both compact and smooth. The AO images rule out double nuclei with separations of greater than 0.1'' (< 1 kpc at z=2), making it unlikely that ongoing major mergers (mass ratios of 1/3 and greater) are triggering the high IR luminosities. By contrast, high resolution images of z~2 SCUBA sources tend to show multiple components and a higher degree of asymmetry. We compare near-IR morphologies of the DOGs with a set of z=1 luminous infrared galaxies (LIRGs; L_IR ~ 10^11 L_sun) imaged with Keck LGSAO by the Center for Adaptive Optics Treasury Survey. The DOGs in our sample have significantly smaller effective radii, ~1/4 the size of the z=1 LIRGs, and tend towards higher concentrations. The small sizes and high concentrations may help explain the globally obscured rest-frame blue-to-UV emission of the DOGs.Comment: 9 pages, 7 figures, 2 tables, accepted for publication in the Astronomical Journa

The AGN Contribution to the Mid-IR Emission of Luminous Infrared Galaxies

We determine the contribution of AGN to the mid-IR emission of luminous infrared galaxies (LIRGs) at z>0.6 by measuring the mid-IR dust continuum slope of 20,039 mid-IR sources. The 24 micron sources are selected from a Spitzer/MIPS survey of the NOAO Deep Wide-Field Survey Bo\"otes field and have corresponding 8 micron data from the IRAC Shallow Survey. There is a clear bimodal distribution in the 24 micron to 8 micron flux ratio. The X-ray detected sources fall within the peak corresponding to a flat spectrum in nufnu, implying that it is populated by AGN-dominated LIRGs, whereas the peak corresponding to a higher 24 micron to 8 micron flux ratio is likely due to LIRGs whose infrared emission is powered by starbursts. The 24 micron emission is increasingly dominated by AGN at higher 24 micron flux densities (f_24): the AGN fraction of the z>0.6 sources increases from ~9% at f_24 ~ 0.35 mJy to 74+/-20% at f_24 ~ 3 mJy in good agreement with model predictions. Deep 24 micron, small area surveys, like GOODS, will be strongly dominated by starburst galaxies. AGN are responsible for ~ 3-7% of the total 24 micron background.Comment: 6 pages, accepted for publication in Ap

HST Morphologies of z~2 Dust Obscured Galaxies I: Power-law Sources

We present high spatial resolution optical and near-infrared imaging obtained using the ACS, WFPC2 and NICMOS cameras aboard the Hubble Space Telescope of 31 24um--bright z~2 Dust Obscured Galaxies (DOGs) identified in the Bootes Field of the NOAO Deep Wide-Field Survey. Although this subset of DOGs have mid-IR spectral energy distributions dominated by a power-law component suggestive of an AGN, all but one of the galaxies are spatially extended and not dominated by an unresolved component at rest-frame UV or optical wavelengths. The observed V-H and I-H colors of the extended components are 0.2-3 magnitudes redder than normal star-forming galaxies. All but 1 have axial ratios >0.3, making it unlikely that DOGs are composed of an edge-on star-forming disk. We model the spatially extended component of the surface brightness distributions of the DOGs with a Sersic profile and find effective radii of 1-6 kpc. This sample of DOGs is smaller than most sub-millimeter galaxies (SMGs), but larger than quiescent high-redshift galaxies. Non-parametric measures (Gini and M20) of DOG morphologies suggest that these galaxies are more dynamically relaxed than local ULIRGs. We estimate lower limits to the stellar masses of DOGs based on the rest-frame optical photometry and find that these range from ~10^(9-11) M_sun. If major mergers are the progenitors of DOGs, then these observations suggest that DOGs may represent a post-merger evolutionary stage.Comment: 23 pages, 9 figures, 6 tables, accepted to ApJ; lower limits on stellar mass revised upwards by factor of (1+z

Galactic Rotation Parameters from Data on Open Star Clusters

Currently available data on the field of velocities Vr, Vl, Vb for open star clusters are used to perform a kinematic analysis of various samples that differ by heliocentric distance, age, and membership in individual structures (the Orion, Carina--Sagittarius, and Perseus arms). Based on 375 clusters located within 5 kpc of the Sun with ages up to 1 Gyr, we have determined the Galactic rotation parameters Wo =-26.0+-0.3 km/s/kpc, W'o = 4.18+-0.17 km/s/kpc^2, W''o=-0.45+-0.06 km/s/kpc^3, the system contraction parameter K = -2.4+-0.1 km/s/kpc, and the parameters of the kinematic center Ro =7.4+-0.3 kpc and lo = 0+-1 degrees. The Galactocentric distance Ro in the model used has been found to depend significantly on the sample age. Thus, for example, it is 9.5+-0.7 kpc and 5.6+-0.3 kpc for the samples of young (50 Myr) clusters, respectively. Our study of the kinematics of young open star clusters in various spiral arms has shown that the kinematic parameters are similar to the parameters obtained from the entire sample for the Carina-Sagittarius and Perseus arms and differ significantly from them for the Orion arm. The contraction effect is shown to be typical of star clusters with various ages. It is most pronounced for clusters with a mean age of 100 Myr, with the contraction velocity being Kr = -4.3+-1.0 km/s.Comment: 14 pages, 4 figures, 2 table

MicroRNA-24 regulates vascularity after myocardial infarction

BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS: Here, we show that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays. Respective downstream signaling cascades involving phosphorylated BAD (Bcl-XL/Bcl-2-associated death promoter) and Sirtuin1 were identified by transcriptome, protein arrays, and chromatin immunoprecipitation analyses. Overexpression of miR-24 or silencing of its targets significantly impaired angiogenesis in zebrafish embryos. Blocking of endothelial miR-24 limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. CONCLUSIONS: Our findings indicate that miR-24 acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease. [KEYWORDS: Animals, Apoptosis/drug effects, Arterioles/pathology, Capillaries/pathology, Cell Hypoxia, Cells, Cultured/drug effects/metabolism, Collagen, Drug Combinations, Drug Evaluation, Preclinical, Endothelial Cells/ metabolism/pathology, GATA2 Transcription Factor/biosynthesis/genetics, Gene Expression Profiling, Heart Failure/etiology, Heme Oxygenase-1/biosynthesis/genetics, Laminin, Male, Mice, Mice, Inbred C57BL, MicroRNAs/antagonists & inhibitors/genetics/ physiology, Myocardial Infarc

Italian Science Case for ALMA Band 2+3

The Premiale Project "Science and Technology in Italy for the upgraded ALMA Observatory - iALMA" has the goal of strengthening the scientific, technological and industrial Italian contribution to the Atacama Large Millimeter/submillimeter Array (ALMA), the largest ground based international infrastructure for the study of the Universe in the microwave. One of the main objectives of the Science Working Group (SWG) inside iALMA, the Work Package 1, is to develop the Italian contribution to the Science Case for the ALMA Band 2 or Band 2+3 receiver. ALMA Band 2 receiver spans from ~67 GHz (bounded by an opaque line complex of ozone lines) up to 90 GHz which overlaps with the lower frequency end of ALMA Band 3. Receiver technology has advanced since the original definition of the ALMA frequency bands. It is now feasible to produce a single receiver which could cover the whole frequency range from 67 GHz to 116 GHz, encompassing Band 2 and Band 3 in a single receiver cartridge, a so called Band 2+3 system. In addition, upgrades of the ALMA system are now foreseen that should double the bandwidth to 16 GHz. The science drivers discussed below therefore also discuss the advantages of these two enhancements over the originally foreseen Band 2 system.Comment: 43 pages, 21 figure