A Window On The Earliest Star Formation: Extreme Photoionization Conditions of a High-Ionization, Low-Metallicity Lensed Galaxy at z~2

We report new observations of SL2SJ021737-051329, a lens system consisting of a bright arc at z=1.84435, magnified ~17x by a massive galaxy at z=0.65. SL2SJ0217 is a low-mass (M <10^9 M*), low-metallicity (Z~1/20 Z*) galaxy, with extreme star-forming conditions that produce strong nebular UV emission lines in the absence of any apparent outflows. Here we present several notable features from rest-frame UV Keck/LRIS spectroscopy: (1) Very strong narrow emission lines are measured for CIV 1548,1550, HeII 1640, OIII] 1661,1666, SiIII] 1883,1892, and CIII] 1907,1909. (2) Double-peaked LyA emission is observed with a dominant blue peak and centered near the systemic velocity. (3) The low- and high-ionization absorption features indicate very little or no outflowing gas along the sightline to the lensed galaxy. The relative emission line strengths can be reproduced with a very high-ionization, low-metallicity starburst with binaries, with the exception of He \ii, which indicates an additional ionization source is needed. We rule out large contributions from AGN and shocks to the photoionization budget, suggesting that the emission features requiring the hardest radiation field likely result from extreme stellar populations that are beyond the capabilities of current models. Therefore, SL2S0217 serves as a template for the extreme conditions that are important for reionization and thought to be more common in the early Universe.Comment: 28 pages, 16 figures, 8 tables, re-submitted to ApJ, comments welcom

Long-term Disease-free Survival Following Combination Multi-visceral and Metastatic Resection with Neoadjuvant FOLFIRINOX for Pancreatic Adenocarcinoma: A Case Report.

We describe a case of metastatic pancreatic adenocarcinoma treated with neoadjuvant FOLFIRINOX chemotherapy and combined pancreatic multi-visceral and metastatic liver resection in a patient currently disease-free four years after diagnosis

Probing dark matter substructure in the gravitational lens HE0435-1223 with the WFC3 grism

Strong gravitational lensing provides a powerful test of Cold Dark Matter (CDM) as it enables the detection and mass measurement of low mass haloes even if they do not contain baryons. Compact lensed sources such as Active Galactic Nuclei (AGN) are particularly sensitive to perturbing subhalos, but their use as a test of CDM has been limited by the small number of systems which have significant radio emission which is extended enough avoid significant lensing by stars in the plane of the lens galaxy, and red enough to be minimally affected by differential dust extinction. Narrow-line emission is a promising alternative as it is also extended and, unlike radio, detectable in virtually all optically selected AGN lenses. We present first results from a WFC3 grism narrow-line survey of lensed quasars, for the quadruply lensed AGN HE0435-1223. Using a forward modelling pipeline which enables us to robustly account for spatial blending, we measure the [OIII] 5007 \AA~ flux ratios of the four images. We find that the [OIII] fluxes and positions are well fit by a simple smooth mass model for the main lens. Our data rule out a $M_{600}>10^{8} (10^{7.2}) M_\odot$ NFW perturber projected within $\sim$1\farcs0 (0\farcs1) arcseconds of each of the lensed images, where $M_{600}$ is the perturber mass within its central 600 pc. The non-detection is broadly consistent with the expectations of $\Lambda$CDM for a single system. The sensitivity achieved demonstrates that powerful limits on the nature of dark matter can be obtained with the analysis of $\sim20$ narrow-line lenses.Comment: Accepted for publication in MNRAS, 15 pages, 8 figure

Preparing for pandemic influenza: the need for enhanced surveillance.

Link_to_subscribed_fulltex

The Grism Lens-Amplified Survey from Space (GLASS). XII. Spatially Resolved Galaxy Star Formation Histories and True Evolutionary Paths at z > 1

Modern data empower observers to describe galaxies as the spatially and biographically complex objects they are. We illustrate this through case studies of four, $z\sim1.3$ systems based on deep, spatially resolved, 17-band + G102 + G141 Hubble Space Telescope grism spectrophotometry. Using full spectrum rest-UV/-optical continuum fitting, we characterize these galaxies' observed $\sim$kpc-scale structures and star formation rates (SFRs) and reconstruct their history over the age of the universe. The sample's diversity---passive to vigorously starforming; stellar masses $\log M_*/M_\odot=10.5$ to $11.2$---enables us to draw spatio-temporal inferences relevant to key areas of parameter space (Milky Way- to super-Andromeda-mass progenitors). Specifically, we find signs that bulge mass-fractions ($B/T$) and SF history shapes/spatial uniformity are linked, such that higher $B/T$s correlate with "inside-out growth" and central specific SFRs that peaked above the global average for all starforming galaxies at that epoch. Conversely, the system with the lowest $B/T$ had a flat, spatially uniform SFH with normal peak activity. Both findings are consistent with models positing a feedback-driven connection between bulge formation and the switch from rising to falling SFRs ("quenching"). While sample size forces this conclusion to remain tentative, this work provides a proof-of-concept for future efforts to refine or refute it: JWST, WFIRST, and the 30-m class telescopes will routinely produce data amenable to this and more sophisticated analyses. These samples---spanning representative mass, redshift, SFR, and environmental regimes---will be ripe for converting into thousands of sub-galactic-scale empirical windows on what individual systems actually looked like in the past, ushering in a new dialog between observation and theory.Comment: 18 pp, 15 figs, 3 tables (main text); 5 pp, 5 figs, 1 table (appendix); Submitted to AAS Journals 1 October 201

Spatially Extended Low Ionization Emission Regions (LIERs) at z∼0.9z\sim0.9

We present spatially resolved emission diagnostics for eight $z\sim0.9$ galaxies that demonstrate extended low ionization emission-line regions (LIERs) over kpc scales. Eight candidates are selected based on their spatial extent and emission line fluxes from slitless spectroscopic observations with the HST/WFC3 G141 and G800L grisms in the well-studied GOODS survey fields. Five of the candidates (62.5%) are matched to X-ray counterparts in the \textit{Chandra X-Ray Observatory} Deep Fields. We modify the traditional Baldwin-Philips-Terlevich (BPT) emission line diagnostic diagram to use [SII]/(H$\alpha$+[NII]) instead of [NII]/H$\alpha$ to overcome the blending of [NII] and H$\alpha$+[NII] in the low resolution slitless grism spectra. We construct emission line ratio maps and place the individual pixels in the modified BPT. The extended LINER-like emission present in all of our candidates, coupled with X-Ray properties consistent with star-forming galaxies and weak [OIII]$\lambda$5007\AA\ detections, is inconsistent with purely nuclear sources (LINERs) driven by active galactic nuclei. While recent ground-based integral field unit spectroscopic surveys have revealed significant evidence for diffuse LINER-like emission in galaxies within the local universe $(z\sim0.04)$, this work provides the first evidence for the non-AGN origin of LINER-like emission out to high redshifts.Comment: 11 pages, 1 table, 6 figures, accepted for publication in the Astrophysics Journal (ApJ

Neural responses to facial and vocal expressions of fear and disgust

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus

2-Amino­anilinium 2-chloro­acetate

In the crystal structure of the title compound, C6H9N2 +·ClCH2COO−, prepared by the reaction of OPDA (orthophenelynediamine) with chloro­acetic ­acid, N—H⋯O hydrogen bonds generate ladder-like chains and very weak inter­molecular C—H⋯Cl hydrogen-bonding inter­actions between the anions and cations lead to a supra­molecular network. C—H⋯O inter­actions also occur

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

Background. Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia. Method. fMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 agematched healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic load. Results. In all groups, increasing mnemonic load was associated with activation in the medial frontal and medial posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the conditions. However, there was a significant group difference in the response of the right precuneus across repeated trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS. Conclusions. Abnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task may be a neural correlate of increased vulnerability to psychosis