Red contra la tuberculosis y por la solidaridad: El compromiso de la sociedad civil

Despite the progress made in the last years, the Tuberculosis remains a relevant public health problem in many geographic areas of the world. Tuberculosis is the paradigm of infectious disease with a high social component, and in its approach, measures aimed at reducing poverty, economic inequality and the integration of the most vulnerable groups cannot be ignored. Therefore, solidarity and social justice are terms associated with the control of this disease. The TBS Network, made up of various institutions born from civil society, tries to inform society and professionals about aspects of tuberculosis prevention, control, diagnosis, treatment and investigation, trying to avoid the stigma that still accompanies many patients. Among the activities organized by the TBS Network are, among others, the Solidarity Cinema Forum (in prisons, Cruz Roja premises and NGOs), Informa TB and Update Days.A pesar de los avances obtenidos en los últimos años, la tuberculosis sigue siendo un problema relevante de salud pública en muchas zonas geográficas del mundo. La tuberculosis es el paradigma de enfermedad infecciosa con un alto componente social, y en su abordaje no pueden soslayarse las medidas tendentes a disminuir la pobreza, las desigualdades económicas y la integración de los colectivos más vulnerables. Por ello, la solidaridad y la justicia social son términos asociados al control de esta enfermedad. La Red TBS, integrada por diversas instituciones nacidas de la sociedad civil, intenta informar a la sociedad y a los profesionales sobre aspectos de prevención, control, diagnóstico, tratamiento e investigación de la tuberculosis, intentando evitar el estigma que acompaña todavía a muchos pacientes. Entre las actividades que organiza la Red TBS se encuentran, entre otras, el Cinefórum Solidario (en prisiones, locales de Cruz Roja y ONGs), Informa TB y Jornadas de Actualización

On-the-fly Informed Search of Non-blocking Directed Controllers

We study directed control of discrete event system expressed as the parallel composition of interacting automata. Solutions that first compose the automata and then compute a controller may result in an exponential blow up. We present a technique that builds the composition on-the-fly guided by a novel domain-independent heuristic, which attempts to discover relevant dependencies between the intervening components. We obtain safe and non-blocking directed controllers, or directors, exploring a reduced portion of the state space. We present the first experimental results on directed control comparing on-the-fly composition with informed search against the original monolithic approach to directed control

Supplementary Material for: Predictor Variables of Developing Anterior Pituitary Deficiencies in a Group of Paediatric Patients with Central Diabetes Insipidus and Langerhans Cell Histiocytosis

<p><b><i>Background:</i></b> Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Central diabetes insipidus (CDI) is the most frequent endocrine manifestation and is a known risk factor for the development of further anterior pituitary hormone deficiencies (APD). However, not all CDI patients develop APD, as observed during prolonged periods of follow-up. <b><i>Aim:</i></b> To find predictors of developing APD in LCH children with CDI followed in our institution. <b><i>Methods:</i></b> We retrospectively analysed 44 patients over a median period (quartiles) of 12.3 years (8.79-14.24). Patients were subdivided into group 1 and group 2, according to absence or presence of APD, respectively. The main variables studied were: (1) chronological age (CA) at LCH diagnosis, (2) the primary site of LCH at diagnosis: low risk (LR) and multisystemic risk organs, and (3) the presence of reactivation. <b><i>Results:</i></b> Multivariate Cox regression analysis showed that APD was positively associated with CA at LCH diagnosis [relative risk (RR) 1.14, <i>p</i> < 0.01], the LR clinical form (RR 8.6, <i>p</i> < 0.03), and negatively associated with the presence of reactivations (RR 0.3, <i>p</i> < 0.01). <b><i>Conclusions:</i></b> Patients with older CA at LCH diagnosis, LR clinical forms, and fewer reactivation episodes might represent a subgroup of paediatric LCH CDI patients with a higher risk of developing APD.</p

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

DNA methylation variation at HP / BP3 and TTC9B is modified by estrogen exposure in the rodent hippocampus and was previously shown to be prospectively predictive of postpartum depression (PPD) when modeled in antenatal blood. The objective of this study was to replicate the predictive efficacy of the previously established model in women with and without a previous psychiatric diagnosis and to understand the effects of changing hormone levels on PPD biomarker loci. Using a statistical model trained on DNA methylation data from N = 51 high-risk women, we prospectively predicted PPD status in an independent N = 51 women using first trimester antenatal gene expression levels of HP I BP3 and TTC9B, with an area under the receiver operator characteristic curve (AUC) of 0.81 (95% CI: 0.69-0.92, p<5 x 10(-4)). Modeling DNA methylation of these genes in N = 240 women without a previous psychiatric diagnosis resulted in a cross-sectional prediction of PPD status with an AUC of 0.81 (95% CI: 0.68-0.93, p = 0.01). TTC9B and HP I BP3 DNA methylation at early antenatal time points showed moderate evidence for association to the change in estradiol and allopregnanolone over the course of pregnancy, suggesting that epigenetic variation at these loci may be important for mediating hormonal sensitivity. In addition both loci showed PPD-specific trajectories with age, possibly mediated by age-associated hormonal changes. The data add to the growing body of evidence suggesting that PPD is mediated by differential gene expression and epigenetic sensitivity to pregnancy hormones and that modeling proxies of this sensitivity enable accurate prediction of PPD

High prevalence of BRAF V600E

Targeted therapies with MAPK inhibitors have proven to modulate the clinical manifestations of patients with Langerhans cell histiocytosis (LCH). We explored the presence of BRAFV600E mutation in our cohort of patients with LCH and cholestasis, sclerosing cholangitis, or liver fibrosis that presented resistance to chemotherapy. The BRAFV600E mutation was detected either in the diagnosis (skin and bone) or liver biopsy in our cohort of 13 patients. Thus, we observed a high incidence of BRAFV600E mutation in 100% either in diagnostic biopsy (skin and bone) or liver biopsy in patients with progressive liver disease, sequela, or liver transplant requirement.Fil: Carrere, Xiomara. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Pinto, Nicolás Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gene Olaciregui, Nagore. Hospital Sant Joan de Déu; EspañaFil: Galluzzo, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Rossetti, Estefania. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Celis Passini, Veronica. Hospital Sant Joan de Déu; EspañaFil: Salvador Marcos, Noelia. Hospital Sant Joan de Déu; EspañaFil: Chantada, Guillermo Luis. Hospital Sant Joan de Déu; España. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Braier, Jorge. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Lavarino, Cinzia. Hospital Sant Joan de Déu; EspañaFil: Felizzia, Guido. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentin