Monitoring Conceptual Development: Design Considerations of a Formative Feedback tool

This paper presents the design considerations of a tool aiming at providing formative feedback. The tool uses Latent Semantic Analysis, to automatically generate reference models and provide learners a means to compare their conceptual development against these models. The design of the tool considers a theoretical background which combines research on expertise development, knowledge creation, and conceptual development assessment. The paper also illustrates how the tool will work using a problem and solution scenario, and presents initial validations results. Finally the paper draws conclusions and future work

Using language technologies to support individual formative feedback

In modern educational environments for group learning it is often challenging for tutors to provide timely individual formative feedback to learners. Taking the case of undergraduate Medicine, we have found that formative feedback is generally provided to learners on an ad-hoc basis, usually at the group, rather than individual, level. Consequently, conceptual issues for individuals often remain undetected until summative assessment. In many subject domains, learners will typically produce written materials to record their study activities. One way for tutors to diagnose conceptual development issues for an individual learner would be to analyse the contents of the learning materials they produce, which would be a significant undertaking. CONSPECT is one of six core web-based services of the Language Technologies for Lifelong Learning (LTfLL) project. This European Union Framework 7-funded project seeks to make use of Language Technologies to provide semi-automated analysis of the large quantities of text generated by learners through the course of their learning. CONSPECT aims to provide formative feedback and monitoring of learners’ conceptual development. It uses a Natural Language Processing method, based on Latent Semantic Analysis, to compare learner materials to reference models generated from reference or learning materials. This paper provides a summary of the service development alongside results from validation of Version 1.0 of the service

Routine application of SFC-MS in doping control: Analysis of 3 × 1000 urine samples using three different SFC-MS instruments

Supercritical fluid chromatography-mass spectrometry (SFC-MS) has proved to be a beneficial tool for sample analysis for a wide variety of compounds and, as such, has recently gained the attention of the anti-doping community. We have tested the applicability of SFC-MS for routine doping control analysing approximately 3 × 1000 identical anti-doping samples utilising SFC-MS instruments from three different vendors: Agilent Technologies, Waters Corporation and Shimadzu Corporation. A ‘dilute and inject’ approach either without or after hydrolysis of glucuronide metabolites was applied. Most of the compounds included in our study demonstrated excellent chromatography, whereas some showed co-elution with endogenous interferences requiring MS discrimination. Retention times typically were very stable within batches (%CV ≤ 0.5%), although this appeared to be analyte and column dependent. Chromatographic peak shape was good (symmetrical) and stable over the period of the testing without any change of column. Our results suggest that SFC-MS is a sensitive, reproducible and robust analytical tool ready to be used in anti-doping laboratories alongside the currently applied techniques such as gas and liquid chromatography coupled to mass spectrometry. Even if instruments are designed slightly differently, all three setups demonstrated their fitness for the purpose in anti-doping testing

Accelerated tibial fracture union in the third trimester of pregnancy: a case report

<p>Abstract</p> <p>Introduction</p> <p>We present a case of accelerated tibial fracture union in the third trimester of pregnancy. This is of particular relevance to orthopaedic surgeons, who must be made aware of the potentially accelerated healing response in pregnancy and the requirement for prompt treatment.</p> <p>Case presentation</p> <p>A 40 year old woman at 34 weeks gestational age sustained a displaced fracture of the tibial shaft. This was initially treated conservatively in plaster with view to intra-medullary nailing postpartum. Following an emergency caesarean section, the patient was able to fully weight bear without pain 4 weeks post injury, indicating clinical union. Radiographs demonstrated radiological union with good alignment and abundant callus formation. Fracture union occurred within 4 weeks, less than half the time expected for a conservatively treated tibial shaft fracture.</p> <p>Conclusion</p> <p>Long bone fractures in pregnancy require clear and precise management plans as fracture healing is potentially accelerated. Non-operative treatment is advisable provided satisfactory alignment of the fracture is achieved.</p

Students' attitudes towards the introduction of a Personal and Professional Development portfolio: potential barriers and facilitators

Peer reviewedPublisher PD

D7.4 Validation 4

Armitt, G., Stoyanov, S., Hensgens, J., Smithies, A., Braidman, I., Mauerhofer, C., Osenova, P., Simov, K., Berlanga, A. J., Van Bruggen, J., Greller, W., Rebedea, T., Posea, V., Trausan-Matu, S., Dupre, D., Salem, H., Dessus, P., Loiseau, M., Westerhout, E., Monachesi, P., Koblische, R., Hoisl, B., Haley, D., & Wild, F. (2011). D7.4 Validation 4. LTfLL-project.This deliverable describes the objectives, approach, planning and results of the third pilot round, in which both individual and threaded services underwent validation. The two goals of this round were to provide input to the LTfLL exploitation plan and roadmap (deliverable 2.5). 531 participants (316 learners) took part in the pilots, which used LTfLL services based on five different languages. The average timespan of the pilots was three weeks and involved learners, tutors, teaching managers, the LTfLL team and Technology Enhanced Learning experts. The validation approach was based on Prototypical Validation Topics derived from the Round 2 validation topics, which refocused the validation topics on exploitation and allowed conclusions to be drawn across all services. Results demonstrated the areas of strength and weakness of each service, informing the selling points and barriers to adoption within the exploitation strategy, as well as suggesting possible further contexts of use. All services were noted to have high relevance in addressing burning issues for organizations, but further improvements to accuracy from a user viewpoint are required. Results on future enhancements to improve likelihood of adoption contribute to the roadmap. Results also provide an indication of each service's current readiness for adoption and provided insights into transferability issues. The overall conclusion is that some LTfLL services are more ready than others for adoption now, with some being currently more suited to sustainability in research settings.The work on this publication has been sponsored by the LTfLL STREP that is funded by the European Commission's 7th Framework Programme. Contract 212578 [http://www.ltfll-project.org

Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study.

The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways. Some athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/β-catenin signalling pathways with low BMD in elite and pre-elite dancers (impact sport athletes). The study included three phases: (1) 151 elite and pre-elite dancers were screened for the presence of low BMD and traditional osteoporosis risk factors (low body weight, menstrual disturbances, low energy availability); (2) a genetic association study was conducted in 151 elite and pre-elite dancers and age- and sex- controls; (3) serum sclerostin was measured in 101 pre-elite dancers and age- and sex-matched controls within a 3-year period. Eighty dancers revealed low BMD: 56.3% had at least one traditional osteoporosis risk factor, whereas 28.6% did not display any risk factor (37.2% revealed traditional osteoporosis risk factors, but had normal BMD). Body weight, menstrual disturbances and energy availability did not fully predict bone mass acquisition. Instead, genetic polymorphisms in the ER and Wnt/β-catenin pathways were found to be risk factors for low BMD in elite dancers. Sclerostin was significantly increased in dancers compared to controls during the 3-year follow-up (p < 0.05)

The Regulation of MS-KIF18A Expression and Cross Talk with Estrogen Receptor

This study provides a novel view on the interactions between the MS-KIF18A, a kinesin protein, and estrogen receptor alpha (ERα) which were studied in vivo and in vitro. Additionally, the regulation of MS-KIF18A expression by estrogen was investigated at the gene and protein levels. An association between recombinant proteins; ERα and MS-KIF18A was demonstrated in vitro in a pull down assay. Such interactions were proven also for endogenous proteins in MBA-15 cells were detected prominently in the cytoplasm and are up-regulated by estrogen. Additionally, an association between these proteins and the transcription factor NF-κB was identified. MS-KIF18A mRNA expression was measured in vivo in relation to age and estrogen level in mice and rats models. A decrease in MS-KIF18A mRNA level was measured in old and in OVX-estrogen depleted rats as compared to young animals. The low MS-KIF18A mRNA expression in OVX rats was restored by estrogen treatment. We studied the regulation of MS-KIF18A transcription by estrogen using the luciferase reporter gene and chromatin immuno-percipitation (ChIP) assays. The luciferase reporter gene assay demonstrated an increase in MS-KIF18A promoter activity in response to 10−8 M estrogen and 10−7M ICI-182,780. Complimentary, the ChIP assay quantified the binding of ERα and pcJun to the MS-KIF18A promoter that was enhanced in cells treated by estrogen and ICI-182,780. In addition, cells treated by estrogen expressed higher levels of MS-KIF18A mRNA and protein and the protein turnover in MBA-15 cells was accelerated. Presented data demonstrated that ERα is a defined cargo of MS-KIF18A and added novel insight on the role of estrogen in regulation of MS-KIF18A expression both in vivo and in vitro

The regulation by sex hormones of tryptophan oxygenase and two other amino-acid metabolising enzymes in rate liver

Imperial Users onl