Professionalism and the Millbank Tendency: The Political Sociology of New Labour's employees

This article analyses party employees, one of the most under-researched subjects in the study of British political parties. We draw on a blend of quantitative and qualitative data in order to shed light on the social and political profiles of Labour Party staff, and on the question of their professionalisation. The latter theme is developed through a model derived from the sociology of professions. While a relatively limited proportion of party employees conform to the pure ideal-type of professionalism, a considerably greater number manifest enough of the core characteristics of specialisation, commitment, mobility, autonomy and self-regulation to be reasonably described as 'professionals in pursuit of political outcomes'

Long-term outcomes for adults with chronic granulomatous disease in the United Kingdom

Uncorrected CGD is associated with significant morbidity and mortality in adulthood, in particular due to inflammatory complications including life-limiting interstitial lung disease

Effects of go/no-go training on food-related action tendencies, liking and choice

This is the final version. Available on open access from the Royal Society via the DOI in this recordData accessibility: All study data and analysis scripts are freely available on the Open Science Framework (https://osf.io/hz2nb/). The study protocol was preregistered prior to data collection at https://osf.io/wav8p. The data are provided in electronic supplementary material [86].Inhibitory control training effects on behaviour (e.g. 'healthier' food choices) can be driven by changes in affective evaluations of trained stimuli, and theoretical models indicate that changes in action tendencies may be a complementary mechanism. In this preregistered study, we investigated the effects of food-specific go/no-go training on action tendencies, liking and impulsive choices in healthy participants. In the training task, energy-dense foods were assigned to one of three conditions: 100% inhibition (no-go), 0% inhibition (go) or 50% inhibition (control). Automatic action tendencies and liking were measured pre- and post-training for each condition. We found that training did not lead to changes in approach bias towards trained foods (go and no-go relative to control), but we warrant caution in interpreting this finding as there are important limitations to consider for the employed approach-avoidance task. There was only anecdotal evidence for an effect on food liking, but there was evidence for contingency learning during training, and participants were on average less likely to choose a no-go food compared to a control food after training. We discuss these findings from both a methodological and theoretical standpoint and propose that the mechanisms of action behind training effects be investigated further.Economic and Social Research Council (ESRC)Biotechnology and Biological Sciences Research Council (BBSRC)European Research Council (ERC

Heme Oxygenase Isoforms Differ in Their Subcellular Trafficking during Hypoxia and Are Differentially Modulated by Cytochrome P450 Reductase

Heme oxygenase (HO) degrades heme in concert with NADPH cytochrome P450 reductase (CPR) which donates electrons to the reaction. Earlier studies reveal the importance of the hydrophobic carboxy-terminus of HO-1 for anchorage to the endoplasmic reticulum (ER) which facilitates the interaction with CPR. In addition, HO-1 has been shown to undergo regulated intramembrane proteolysis of the carboxy-terminus during hypoxia and subsequent translocation to the nucleus. Translocated nuclear HO-1 was demonstrated to alter binding of transcription factors and to alter gene expression. Little is known about the homologous membrane anchor of the HO-2 isoform. The current work is the first systematic analysis in a eukaryotic system that demonstrates the crucial role of the membrane anchor of HO-2 for localization at the endoplasmic reticulum, oligomerization and interaction with CPR. We show that although the carboxy-terminal deletion mutant of HO-2 is found in the nucleus, translocation of HO-2 to the nucleus does not occur under conditions of hypoxia. Thus, we demonstrate that proteolytic regulation and nuclear translocation under hypoxic conditions is specific for HO-1. In addition we show for the first time that CPR prevents this translocation and promotes oligomerization of HO-1. Based on these findings, CPR may modulate gene expression via the amount of nuclear HO-1. This is of particular relevance as CPR is a highly polymorphic gene and deficiency syndromes of CPR have been described in humans

New Liverwort (Marchantiophyra) records for the Fiji Islands

Forty-eight species of liverworts (Marchantiophyta) are reported as new to the Fiji Islands. These records increase the number of Fijian liverworts by over 20%. Extension of range within Fiji are reported for an additional 39 taxa already known to occur within the Fijian archipelago. These records indicate that the Fijian flora is understudied and many localities in Fiji, including entire islands, remain under-collected for bryophytes. Metalejeunea crassitexta (J.B.Jack et Steph.) Pocs is proposed as a new combination, and Lejeunea microstipula Steph. is reduced to a synonym of Lejeunea exilis (Reinw., Blume et Nees) Grolle

A brief history of the cryptogams of Fiji and prospects for the future

A brief history of Fijian cryptogams, including bryophytes, ferns and lycophytes, and lichenised fungi is provided. Brief comments on the future prospects for the systematic and conservation of these groups of organisms are provided. An overview of the six Fijian contributions is also provided. In contrast to many other biodiversity hotspots, the current study highlights our limited floristic knowledge of the Fijian cryptogams

Unlocking collections: New records of Lepidoziaceae (Marchantiophyta) for the islands of Fiji

It is clearly evident that the bryophyte flora of the islands of Fiji remains inadequately documented. Here, five liverwort species of Lepidoziaceae are reported as new to the Republic of Fiji: Lepidozia haskarliana, Neolepidozia cuneifolia, N. wallichiana, Telaranea major and Tricholepidozia melanesica