314 research outputs found
Pair of accelerated black holes in a de Sitter background: the dS C-metric
Following the work of Kinnersley and Walker for flat spacetimes, we have
analyzed the anti-de Sitter C-metric in a previous paper. In the de Sitter
case, Podolsky and Griffiths have established that the de Sitter C-metric (dS
C-metric) found by Plebanski and Demianski describes a pair of accelerated
black holes in the dS background with the acceleration being provided (in
addition to the cosmological constant) by a strut that pushes away the two
black holes or, alternatively, by a string that pulls them. We extend their
analysis mainly in four directions. First, we draw the Carter-Penrose diagrams
of the massless uncharged dS C-metric, of the massive uncharged dS C-metric and
of the massive charged dS C-metric. These diagrams allow us to clearly identify
the presence of two dS black holes and to conclude that they cannot interact
gravitationally. Second, we revisit the embedding of the dS C-metric in the 5D
Minkowski spacetime and we represent the motion of the dS C-metric origin in
the dS 4-hyperboloid as well as the localization of the strut. Third, we
comment on the physical properties of the strut that connects the two black
holes. Finally, we find the range of parameters that correspond to non-extreme
black holes, extreme black holes, and naked particles.Comment: 11 pages, 11 figures (RevTeX4). Published version: references adde
A direct numerical simulation method for complex modulus of particle dispersions
We report an extension of the smoothed profile method (SPM)[Y. Nakayama, K.
Kim, and R. Yamamoto, Eur. Phys. J. E {\bf 26}, 361(2008)], a direct numerical
simulation method for calculating the complex modulus of the dispersion of
particles, in which we introduce a temporally oscillatory external force into
the system. The validity of the method was examined by evaluating the storage
and loss moduli of a system composed of identical
spherical particles dispersed in an incompressible Newtonian host fluid at
volume fractions of , 0.41, and 0.51. The moduli were evaluated at
several frequencies of shear flow; the shear flow used here has a zigzag
profile, as is consistent with the usual periodic boundary conditions
Strong Phase Separation in a Model of Sedimenting Lattices
We study the steady state resulting from instabilities in crystals driven
through a dissipative medium, for instance, a colloidal crystal which is
steadily sedimenting through a viscous fluid. The problem involves two coupled
fields, the density and the tilt; the latter describes the orientation of the
mass tensor with respect to the driving field. We map the problem to a 1-d
lattice model with two coupled species of spins evolving through conserved
dynamics. In the steady state of this model each of the two species shows
macroscopic phase separation. This phase separation is robust and survives at
all temperatures or noise levels--- hence the term Strong Phase Separation.
This sort of phase separation can be understood in terms of barriers to
remixing which grow with system size and result in a logarithmically slow
approach to the steady state. In a particular symmetric limit, it is shown that
the condition of detailed balance holds with a Hamiltonian which has
infinite-ranged interactions, even though the initial model has only local
dynamics. The long-ranged character of the interactions is responsible for
phase separation, and for the fact that it persists at all temperatures.
Possible experimental tests of the phenomenon are discussed.Comment: To appear in Phys Rev E (1 January 2000), 16 pages, RevTex, uses
epsf, three ps figure
Dimensional Dependence of Black Hole Formation in Self-Similar Collapse of Scalar Field
We study classical and quantum self-similar collapses of a massless scalar
field in higher dimensions, and examine how the increase in the number of
dimensions affects gravitational collapse and black hole formation. Higher
dimensions seem to favor formation of black hole rather than other final
states, in that the initial data space for black hole formation enlarges as
dimension increases. On the other hand, the quantum gravity effect on the
collapse lessens as dimension increases. We also discuss the gravitational
collapse in a brane world with large but compact extra dimensions.Comment: Improved a few arguments and added a figur
Simulating (electro)hydrodynamic effects in colloidal dispersions: smoothed profile method
Previously, we have proposed a direct simulation scheme for colloidal
dispersions in a Newtonian solvent [Phys.Rev.E 71,036707 (2005)]. An improved
formulation called the ``Smoothed Profile (SP) method'' is presented here in
which simultaneous time-marching is used for the host fluid and colloids. The
SP method is a direct numerical simulation of particulate flows and provides a
coupling scheme between the continuum fluid dynamics and rigid-body dynamics
through utilization of a smoothed profile for the colloidal particles.
Moreover, the improved formulation includes an extension to incorporate
multi-component fluids, allowing systems such as charged colloids in
electrolyte solutions to be studied. The dynamics of the colloidal dispersions
are solved with the same computational cost as required for solving
non-particulate flows. Numerical results which assess the hydrodynamic
interactions of colloidal dispersions are presented to validate the SP method.
The SP method is not restricted to particular constitutive models of the host
fluids and can hence be applied to colloidal dispersions in complex fluids
Restructuring of colloidal aggregates in shear flow: Coupling interparticle contact models with Stokesian dynamics
A method to couple interparticle contact models with Stokesian dynamics (SD)
is introduced to simulate colloidal aggregates under flow conditions. The
contact model mimics both the elastic and plastic behavior of the cohesive
connections between particles within clusters. Owing to this, clusters can
maintain their structures under low stress while restructuring or even breakage
may occur under sufficiently high stress conditions. SD is an efficient method
to deal with the long-ranged and many-body nature of hydrodynamic interactions
for low Reynolds number flows. By using such a coupled model, the restructuring
of colloidal aggregates under stepwise increasing shear flows was studied.
Irreversible compaction occurs due to the increase of hydrodynamic stress on
clusters. Results show that the greater part of the fractal clusters are
compacted to rod-shaped packed structures, while the others show isotropic
compaction.Comment: A simulation movie be found at
http://www-levich.engr.ccny.cuny.edu/~seto/sites/colloidal_aggregates_shearflow.htm
Regulation of 5-HT Receptors and the Hypothalamic-Pituitary-Adrenal Axis
Disturbances in the serotonin (5-HT) system is the neurobiological abnormality most consistently associated with suicide. Hyperactivity of the hypothalmic-pituitary-adrenal (HPA) axis is also described in suicide victims. The HPA axis is the classical neuroendocrine system that responds to stress and whose final product, corticosteroids, targets components of the limbic system, particularly the hippocampus. We will review resulsts from animal studies that point to the possibility that many of the 5-HT receptor changes observed in suicide brains may be a result of, or may be worsened by, the HPA overactivity that may be present in some suicide victims. The results of these studies can be summarized as follows: (1) chronic unpredictable stress produces high corticosteroid levels in rats; (2) chronic stress also results in changes in specific 5-HT receptors (increases in cortical 5-HT2A and decreases in hipocampal 5-HT1A and 5-HT1B); (3) chronic antidepressant administration prevents many of the 5-HT receptor changes observed after stress; and (4) chronic antidepressant administration reverses the overactivity of the HPA axis. If indeed 5-HT receptors have a partial role in controlling affective states, then their modulation by corticosteroids provides a potential mechanism by which these hormones may regulate mood. These data may also provide a biological understanding of how stressful events may increase the risk for suicide in vulnerable individuals and may help us elucidate the neurobiological underpinnings of treatment resistance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73437/1/j.1749-6632.1997.tb52357.x.pd
Tumour subregion analysis of colorectal liver metastases using semi-automated clustering based on DCE-MRI: Comparison with histological subregions and impact on pharmacokinetic parameter analysis.
PURPOSE: To use a novel segmentation methodology based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to define tumour subregions of liver metastases from colorectal cancer (CRC), to compare these with histology, and to use these to compare extracted pharmacokinetic (PK) parameters between tumour subregions. MATERIALS AND METHODS: This ethically-approved prospective study recruited patients with CRC and ≥1 hepatic metastases scheduled for hepatic resection. Patients underwent DCE-MRI pre-metastasectomy. Histological sections of resection specimens were spatially matched to DCE-MRI acquisitions and used to define histological subregions of viable and non-viable tumour. A semi-automated voxel-wise image segmentation algorithm based on the DCE-MRI contrast-uptake curves was used to define imaging subregions of viable and non-viable tumour. Overlap of histologically-defined and imaging subregions was compared using the Dice similarity coefficient (DSC). DCE-MRI PK parameters were compared for the whole tumour and histology-defined and imaging-derived subregions. RESULTS: Fourteen patients were included in the analysis. Direct histological comparison with imaging was possible in nine patients. Mean DSC for viable tumour subregions defined by imaging and histology was 0.738 (range 0.540-0.930). There were significant differences between Ktrans and kep for viable and non-viable subregions (p < 0.001) and between whole lesions and viable subregions (p < 0.001). CONCLUSION: We demonstrate good concordance of viable tumour segmentation based on pre-operative DCE-MRI with a post-operative histological gold-standard. This can be used to extract viable tumour-specific values from quantitative image analysis, and could improve treatment response assessment in clinical practice
Physics Opportunities with the 12 GeV Upgrade at Jefferson Lab
This white paper summarizes the scientific opportunities for utilization of
the upgraded 12 GeV Continuous Electron Beam Accelerator Facility (CEBAF) and
associated experimental equipment at Jefferson Lab. It is based on the 52
proposals recommended for approval by the Jefferson Lab Program Advisory
Committee.The upgraded facility will enable a new experimental program with
substantial discovery potential to address important topics in nuclear,
hadronic, and electroweak physics.Comment: 64 page
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