Intramedullary Spine Disease

One of the most significant impacts of magnetic resonance (MRI) has been its ability to exquisitely depict normal and pathologic anatomy of the spine. This unit presents a that deals with intramedullary disease, i.e., that involving the cord. An is presented for cases of extramedullary‐intradural disease.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145323/1/cpmia0901.pd

Data Compression Techniques for Advanced Space Transportation Systems

Advanced space transportation systems, including vehicle state of health systems, will produce large amounts of data which must be stored on board the vehicle and or transmitted to the ground and stored. The cost of storage or transmission of the data could be reduced if the number of bits required to represent the data is reduced by the use of data compression techniques. Most of the work done in this study was rather generic and could apply to many data compression systems, but the first application area to be considered was launch vehicle state of health telemetry systems. Both lossless and lossy compression techniques were considered in this study

Shear Bond Strength Comparison between Two Orthodontic Adhesives and Self-Ligating and Conventional Brackets

Objective: To evaluate and compare the shear bond strengths of two adhesives using two types of brackets: a conventional and a self-ligating bracket system. Materials and Methods: Sixty extracted human premolars were collected. The premolars were randomly divided into three groups of 20 teeth. All three groups were direct bonded. Groups 1 and 2 used light-cured adhesive and primer (Transbond XT) with a conventional (Orthos) and a self-ligating bracket (Damon 2), respectively. Group 3 used a light-cured primer (Orthosolo) and a light-cured adhesive (Blūgloo) with a self-ligating bracket (Damon 2). The specimens were stored in distilled water at 37°C for 40 ± 2 hours, after which they were debonded and inspected for Adhesive Remnant Index (ARI) scoring. Results: The mean shear bond strength was 15.2 MPa for group 1, 23.2 MPa for group 2, and 24.8 MPa for group 3. A one-way analysis of variance and post hoc Tukey test showed significant differences in bond strength (P \u3c .001) between group 1 and groups 2 and 3 but no significant difference (P \u3e .05) between groups 2 and 3. A Weibull analysis demonstrated that all three groups provided sufficient bond strength with over 90% survival rate at normal masticatory and orthodontic force levels. A Kruskal-Wallis test showed no significant difference (P \u3e .05) in ARI scores among all three groups. Conclusions: All three groups demonstrated clinically acceptable bond strength. The Damon 2 self-ligating bracket exhibited satisfactory in vitro bond strength with both adhesive systems used

Reweighted LP decoding for LDPC codes

We introduce a novel algorithm for decoding binary linear codes by linear programming. We build on the LP decoding algorithm of Feldman et al. and introduce a post-processing step that solves a second linear program that reweights the objective function based on the outcome of the original LP decoder output. Our analysis shows that for some LDPC ensembles we can improve the provable threshold guarantees compared to standard LP decoding. We also show significant empirical performance gains for the reweighted LP decoding algorithm with very small additional computational complexity

Globular Cluster Systems in Brightest Cluster Galaxies: Bimodal Metallicity Distributions and the Nature of the High-Luminosity Clusters

We present new (B,I) photometry for the globular cluster systems in eight Brightest Cluster Galaxies (BCGs), obtained with the ACS/WFC camera on the Hubble Space Telescope. In the very rich cluster systems that reside within these giant galaxies, we find that all have strongly bimodal color distributions All the BCGs show population gradients, with much higher relative numbers of red clusters within 5 kpc of their centers, consistent with their having formed at later times than the blue, metal-poor population. A striking new feature of the color distributions emerging from our data is that for the brightest clusters (M_I < -10.5) the color distribution becomes broad and less obviously bimodal. we suggest that it may be a characteristic of many BCGs. Furthermore, the blue (metal-poor) clusters become progressively redder with increasing luminosity, following a mass/metallicity scaling relation Z ~ M^0.55. We argue that these GCS characteristics are consistent with a hierarchical-merging formation picture in which the metal-poor clusters formed in protogalactic clouds or dense starburst complexes with gas masses in the range 10^7 - 10^10 M_Sun, but where the more massive clusters on average formed in bigger clouds with deeper potential wells where more pre-enrichment could occur.Comment: 48 pages, 24 Figures, PDF, Submitted to Astrophys.J. and refereed. For complete pdf file with better figures, see: http://physwww.mcmaster.ca/%7Eharris/Preprints.htm

Reweighted LP Decoding for LDPC Codes

We introduce a novel algorithm for decoding binary linear codes by linear programming (LP). We build on the LP decoding algorithm of Feldman and introduce a postprocessing step that solves a second linear program that reweights the objective function based on the outcome of the original LP decoder output. Our analysis shows that for some LDPC ensembles we can improve the provable threshold guarantees compared to standard LP decoding. We also show significant empirical performance gains for the reweighted LP decoding algorithm with very small additional computational complexity

Distributed computation of transient state distributions and passage time quantiles in large semi-Markov models

Submitted versio

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles

Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy. Furthermore, the delivery of therapeutic agents of any kind to PDAC in particular has been hindered by the extensive desmoplasia and resultant drug delivery challenges that accompanies these tumors. Small interfering RNA (siRNA) is a promising modality for anti-neoplastic therapy due to its precision and wide range of potential therapeutic targets. Unfortunately, siRNA therapy is limited by low serum half-life, vulnerability to intracellular digestion, and transient therapeutic effect. We assessed the ability of a peptide based, oligonucleotide condensing, endosomolytic nanoparticle (NP) system to deliver siRNA to KRAS-driven cancers. We show that this peptide-based NP is avidly taken up by cancer cell

The Effect of Experiential Education on Pilots\u27 VFR into IMC Decision-Making

In aviation, safety is always a primary consideration, and this is especially true during a pilot’s flight training to instill that safety mentality. However, this means that pilots are restricted by safety policies from encountering difficult weather situations during their training, which could, potentially, improve their weather decision-making skills for avoiding future hazardous weather encounters. Thirty-six general aviation pilots of varying instrument flight experience (IF) were allocated, using stratified random sampling based on their IF, to one of three groups, a control group and two educational treatment intervention groups. The educational treatment interventions were designed to improve the participant’s ability in recognizing deteriorating weather (reducing visibility) conditions, to prevent flying from visual flight rules (VFR) into instrument meteorological conditions (IMC) by the use of experiential education. Intervention one was web-based only and intervention two was web and personal computer (PC) simulator based. Each pilot flew a simulated flight along a fjord in Alaska under visual flight rules in deteriorating visual weather that became instrument conditions. Type of intervention and experience-related demographic factors were analyzed to determine what factors contributed to safe weather-related decisions. Type of educational treatment intervention was found to be the only statistically significant demographic predictor of safe performance. Pilots who received the web-based only intervention were better able to assess deteriorating visibility and avoid instrument weather. Implications of this study and opportunities for future research are discussed