A Comprehensive View of a Strongly Lensed Planck-Associated Submillimeter Galaxy

We present high-resolution maps of stars, dust, and molecular gas in a strongly lensed submillimeter galaxy (SMG) at z = 3.259. HATLAS J114637.9–001132 is selected from the Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS) as a strong lens candidate mainly based on its unusually high 500 μm flux density (~300 mJy). It is the only high-redshift Planck detection in the 130 deg^2 H-ATLAS Phase-I area. Keck Adaptive Optics images reveal a quadruply imaged galaxy in the K band while the Submillimeter Array and the Jansky Very Large Array show doubly imaged 880 μm and CO(1→0) sources, indicating differentiated distributions of the various components in the galaxy. In the source plane, the stars reside in three major kpc-scale clumps extended over ~1.6 kpc, the dust in a compact (~1 kpc) region ~3 kpc north of the stars, and the cold molecular gas in an extended (~7 kpc) disk ~5 kpc northeast of the stars. The emissions from the stars, dust, and gas are magnified by ~17, ~8, and ~7 times, respectively, by four lensing galaxies at z ~ 1. Intrinsically, the lensed galaxy is a warm (T_(dust) ~ 40-65 K), hyper-luminous (L_(IR) ~ 1.7 × 10^(13) L_☉; star formation rate (SFR) ~2000 M_☉ yr^(–1)), gas-rich (M_(gas)/M_(baryon) ~ 70%), young (M_(stellar)/SFR ~ 20 Myr), and short-lived (M_(gas)/SFR ~ 40 Myr) starburst. With physical properties similar to unlensed z > 2 SMGs, HATLAS J114637.9–001132 offers a detailed view of a typical SMG through a powerful cosmic microscope

Parents, children and the porous boundaries of the sexual family in law and popular culture

This article focuses on a perceived ideological overlap between popular cultural and judicial treatments of sex and conjugality that contributes to a discursive construction of parenthood and parenting. The author perceives that in both legal and popular cultural texts, there is a sense in which notions of ‘natural’ childhood are discursively constituted as being put at risk by those who reproduce outside of dominant sexual norms, and that signs of normative sexuality (typically in the form of heterosexual coupling) may be treated as a sign of safety. These ideas are rooted in ancient associations between fertility, sexuality and femininity that can also be traced in the historical development of the English language. With the help of commentators such as Martha Fineman, the article situates parents and children within a discourse of family which prioritises conjugality, with consequences for the ways in which the internal and external boundaries of families are delineated

Components of good end of life care within the paediatric intensive care setting – an online survey

BACKGROUND This study was undertaken to better understand the components of good end of life for children who are being cared for within the PICU. Cure rates from serious childhood illness are gradually improving every year. Despite this, there are still a small but significant number of children who will die within a Paediatric Intensive Care Unit. OBJECTIVES 1. The primary objective was to determine what the key aspects of End-of-Life-Care/palliative care in PICU as perceived by Health Professionals (including General Paediatricians) 2. This project will result in a schema of components of care which can be used by health professionals within in the intensive care setting to assist with excellent end of life care. METHOD An online survey of health professionals was used to rank various components of palliative care within the PICU context. Survey participants could also suggest other components of care that had not already been thought of within the survey. RESULTS There were 108 respondents who took the survey. The survey group were multidisciplinary (medical 32.4%; nursing 44.44% and allied health 23.15 %). There were also a variety of specialties represented in the survey (PICU 56.5 %; Paediatric Palliative Care 17.4%; General Paediatrics 13.9% and Other 12.2 %). The top 5 components of care ranked by the group included were identified by the interest groups after being ranked according to their importance. These included 1. Discussion of a Management Plan 2. Sensitive, compassionate use of language 3. Discussion of End of Life care 4. Discussion of anticipated changes in the patient's condition 5. Discussion of the caregiver's understanding of the illness. CONCLUSION It is hoped that the schema for good end of life care represents a consensus from a large and diverse group of health professionals. This schema should assist in the day to day care of patients. Further, it should also be of benefit in education, research and quality activities

Truth Table Invariant Cylindrical Algebraic Decomposition by Regular Chains

A new algorithm to compute cylindrical algebraic decompositions (CADs) is presented, building on two recent advances. Firstly, the output is truth table invariant (a TTICAD) meaning given formulae have constant truth value on each cell of the decomposition. Secondly, the computation uses regular chains theory to first build a cylindrical decomposition of complex space (CCD) incrementally by polynomial. Significant modification of the regular chains technology was used to achieve the more sophisticated invariance criteria. Experimental results on an implementation in the RegularChains Library for Maple verify that combining these advances gives an algorithm superior to its individual components and competitive with the state of the art

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain

Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an intracellular family 1 cystatin) with KD2 and Delta L110 deletion mutants of chicken cystatin-KD2 hybrids. Substitution of the N-terminal contact region of stefin B by the corresponding KD2 sequence resulted in a calpain inhibitor of K-i = 188 nM. Deletion of L110, which forms a beta -bulge in family 1 and 2 cystatins but is lacking in KD2, improved inhibition of mu -calpain 4- to 8-fold. All engineered cystatins were temporary inhibitors of calpain due to slow substrate-like cleavage of a single peptide bond corresponding to Gly9-Ala10 in chicken cystatin. Biomolecular interaction analysis revealed that, unlike calpastatin, the cystatin-type inhibitors do not bind to the calmodulin-like domain of the small subunit of calpain, and their interaction with the mu -calpain heterodimer is completely prevented by a synthetic peptide comprising subdomain B of calpastatin domain 1. Based on these results we propose that (i) cystatin-type calpain inhibitors interact with the active site of the catalytic domain of calpain in a similar cystatin-like mode as with papain and (ii) the potential for calpain inhibition is due to specific subsites within the papain-binding regions of the general cystatin fold

Warm Molecular Gas Traced with CO J=7->6 in the Galaxy's Central 2 Parsecs: Dynamical Heating of the Circumnuclear Disk

We present an 11 arcsec resolution map of the central two parsecs of the Galaxy in the CO J =7->6 rotational transition. The CO emission shows rotation about Sgr A*, but also evidence for non-circular turbulent motion and a clumpy morphology. We combine our dataset with available CO measurements to model the physical conditions in the disk. We find that the molecular gas in the region is both warm and dense, with T~200-300 K, n_H2~50,000-70,000 cm^-3. The mass of warm molecular gas we measure in the central two parsecs is at least 2000 M_solar, about 20 times the UV-excited atomic gas mass, ruling out an UV heating scenario for the molecular material. We compare the available spectral tracers with theoretical models and conclude that molecular gas is heated with magneto-hydrodynamic shocks with v~10-20 kms and B~0.3-0.5 mG. Using the conditions derived with the CO analysis, we include the other important coolants--neutral oxygen and molecular hydrogen--to estimate the total cooling budget of the molecular material. We derive a mass to luminosity ratio of 2-3 M_solar/ L_solar, which is consistent with the total power dissipated via turbulent decay in 0.1 pc cells with v_rms~15 kms. These size and velocity scales are comparable to the observed clumping scale and the velocity dispersion. At this rate, the material near Sgr A* its dissipating its orbital energy on an orbital timescale, and cannot last for more than a few orbits. Our conclusions support a scenario in which the features near Sgr A* such as the CND and northern arm are generated by infalling clouds with low specific angular momentum.Comment: 31 pages, including 5 figures, accepted for publication in Ap

Epilogue

China is increasingly aware of the role and potential it can have to influence the world development. This has led it to reconsider and develop foreign policies, the Belt and Road Initiative (BRI) being a new flagship of them. The economic tone in China’s foreign policy has given it a soft flavor.Peer reviewe

Boston Hospitality Review: Winter 2013

Lodging Update: Portland, Maine by Rachel Roginsky and Matthew Arrants -- From Boston to the Balkans: Olmsted’s Emerald Legacy by Christina Luke -- An Important Arrival: Te Anatomy of a Vintage Advertisement by Bradford Hudson -- The Historical Origins of Business Statistics and a Current Application in Lodging Forecasting by Barry A.N. Bloom -- Building Hotel Revenues through Tourism by John D. Murtha -- Revisiting the Glass Ceiling: Career Progression for Women in the Hotel Industry by Zoe H