194 research outputs found
IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment
The IKK/nuclear factor-kappaB pathway (NF-ÎșB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-ÎșB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety of diseases including autoimmune disease, neurodegenerative disease, and, important to this review, cancer. While NF-ÎșB functions in cancer to promote a number of critical oncogenic functions, here we discuss the importance of the NF-ÎșB signaling pathway in contributing to cancer through promotion of the tumor microenvironment and through maintenance/expansion of tumor-initiating cells, processes that appear to be functionally interrelated
Soil biochemistry and microbial activity in vineyards under conventional and organic management at Northeast Brazil.
The SĂŁo Francisco Submedium Valley is located at the Brazilian semiarid region and is an important center for irrigated fruit growing. This region is responsible for 97% of the national exportation of table grapes, including seedless grapes. Based on the fact that orgThe SĂŁo Francisco Submedium Valley is located at the Brazilian semiarid region and is an important center for irrigated fruit growing. This region is responsible for 97% of the national exportation of table grapes, including seedless grapes. Based on the fact that organic fertilization can improve soil quality, we compared the effects of conventional and organic soil management on microbial activity and mycorrhization of seedless grape crops. We measured glomerospores number, most probable number (MPN) of propagules, richness of arbuscular mycorrhizal fungi (AMF) species, AMF root colonization, EE-BRSP production, carbon microbial biomass (C-MB), microbial respiration, fluorescein diacetate hydrolytic activity (FDA) and metabolic coefficient (qCO2). The organic management led to an increase in all variables with the exception of EE-BRSP and qCO2. Mycorrhizal colonization increased from 4.7% in conventional crops to 15.9% in organic crops. Spore number ranged from 4.1 to 12.4 per 50 g-1 soil in both management systems. The most probable number of AMF propagules increased from 79 cm-3 soil in the conventional system to 110 cm-3 soil in the organic system. Microbial carbon, CO2 emission, and FDA activity were increased by 100 to 200% in the organic crop. Thirteen species of AMF were identified, the majority in the organic cultivation system. Acaulospora excavata, Entrophospora infrequens, Glomus sp.3 and Scutellospora sp. were found only in the organically managed crop. S. gregaria was found only in the conventional crop. Organically managed vineyards increased mycorrhization and general soil microbial activity
A Bayesian analysis of pentaquark signals from CLAS data
We examine the results of two measurements by the CLAS collaboration, one of
which claimed evidence for a pentaquark, whilst the other found no
such evidence. The unique feature of these two experiments was that they were
performed with the same experimental setup. Using a Bayesian analysis we find
that the results of the two experiments are in fact compatible with each other,
but that the first measurement did not contain sufficient information to
determine unambiguously the existence of a . Further, we suggest a
means by which the existence of a new candidate particle can be tested in a
rigorous manner.Comment: 5 pages, 3 figure
Electron Scattering From High-Momentum Neutrons in Deuterium
We report results from an experiment measuring the semi-inclusive reaction
where the proton is moving at a large angle relative to the
momentum transfer. If we assume that the proton was a spectator to the reaction
taking place on the neutron in deuterium, the initial state of that neutron can
be inferred. This method, known as spectator tagging, can be used to study
electron scattering from high-momentum (off-shell) neutrons in deuterium. The
data were taken with a 5.765 GeV electron beam on a deuterium target in
Jefferson Laboratory's Hall B, using the CLAS detector. A reduced cross section
was extracted for different values of final-state missing mass ,
backward proton momentum and momentum transfer . The data
are compared to a simple PWIA spectator model. A strong enhancement in the data
observed at transverse kinematics is not reproduced by the PWIA model. This
enhancement can likely be associated with the contribution of final state
interactions (FSI) that were not incorporated into the model. A ``bound neutron
structure function'' was extracted as a function of and
the scaling variable at extreme backward kinematics, where effects of
FSI appear to be smaller. For MeV/c, where the neutron is far
off-shell, the model overestimates the value of in the region of
between 0.25 and 0.6. A modification of the bound neutron structure
function is one of possible effects that can cause the observed deviation.Comment: 33 pages RevTeX, 9 figures, to be submitted to Phys. Rev. C. Fixed 1
Referenc
Complete measurement of three-body photodisintegration of 3He for photon energies between 0.35 and 1.55 GeV
The three-body photodisintegration of 3He has been measured with the CLAS
detector at Jefferson Lab, using tagged photons of energies between 0.35 GeV
and 1.55 GeV. The large acceptance of the spectrometer allowed us for the first
time to cover a wide momentum and angular range for the two outgoing protons.
Three kinematic regions dominated by either two- or three-body contributions
have been distinguished and analyzed. The measured cross sections have been
compared with results of a theoretical model, which, in certain kinematic
ranges, have been found to be in reasonable agreement with the data.Comment: 22 pages, 25 eps figures, 2 tables, submitted to PRC. Modifications:
removed 2 figures, improvements on others, a few minor modifications to the
tex
A Kinematically Complete Measurement of the Proton Structure Function F2 in the Resonance Region and Evaluation of Its Moments
We measured the inclusive electron-proton cross section in the nucleon
resonance region (W < 2.5 GeV) at momentum transfers Q**2 below 4.5 (GeV/c)**2
with the CLAS detector. The large acceptance of CLAS allowed for the first time
the measurement of the cross section in a large, contiguous two-dimensional
range of Q**2 and x, making it possible to perform an integration of the data
at fixed Q**2 over the whole significant x-interval. From these data we
extracted the structure function F2 and, by including other world data, we
studied the Q**2 evolution of its moments, Mn(Q**2), in order to estimate
higher twist contributions. The small statistical and systematic uncertainties
of the CLAS data allow a precise extraction of the higher twists and demand
significant improvements in theoretical predictions for a meaningful comparison
with new experimental results.Comment: revtex4 18 pp., 12 figure
eta-prime photoproduction on the proton for photon energies from 1.527 to 2.227 GeV
Differential cross sections for the reaction gamma p -> eta-prime p have been
measured with the CLAS spectrometer and a tagged photon beam with energies from
1.527 to 2.227 GeV. The results reported here possess much greater accuracy
than previous measurements. Analyses of these data indicate for the first time
the coupling of the etaprime N channel to both the S_11(1535) and P_11(1710)
resonances, known to couple strongly to the eta N channel in photoproduction on
the proton, and the importance of j=3/2 resonances in the process.Comment: 6 pages, 3 figure
Measurement of the Deuteron Structure Function F2 in the Resonance Region and Evaluation of Its Moments
Inclusive electron scattering off the deuteron has been measured to extract
the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer
(CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement
covers the entire resonance region from the quasi-elastic peak up to the
invariant mass of the final-state hadronic system W~2.7 GeV with four-momentum
transfers Q2 from 0.4 to 6 (GeV/c)^2. These data are complementary to previous
measurements of the proton structure function F2 and cover a similar
two-dimensional region of Q2 and Bjorken variable x. Determination of the
deuteron F2 over a large x interval including the quasi-elastic peak as a
function of Q2, together with the other world data, permit a direct evaluation
of the structure function moments for the first time. By fitting the Q2
evolution of these moments with an OPE-based twist expansion we have obtained a
separation of the leading twist and higher twist terms. The observed Q2
behaviour of the higher twist contribution suggests a partial cancellation of
different higher twists entering into the expansion with opposite signs. This
cancellation, found also in the proton moments, is a manifestation of the
"duality" phenomenon in the F2 structure function
First measurement of direct photoproduction on the proton
We report on the results of the first measurement of exclusive
meson photoproduction on protons for GeV and GeV. Data were collected with the CLAS detector at the Thomas
Jefferson National Accelerator Facility. The resonance was detected via its
decay in the channel by performing a partial wave analysis of the
reaction . Clear evidence of the meson
was found in the interference between and waves at GeV. The -wave differential cross section integrated in the mass range of
the was found to be a factor of 50 smaller than the cross section
for the meson. This is the first time the meson has been
measured in a photoproduction experiment
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