Effects of supplemental unemployment benefits plans.

Thesis (M.B.A.)--Boston University N.B.: Pages 62 and 102 are misnumbered. No content is missing

Account Book, Lobster Fishermen, 1911-1917

Account book records lobster, cod, mackerel, haddock, herring and other fish catch and sales, as well as purchases of supplies for individual Lobster fishermen of Monhegan Island, including Maynard Brackett, C.B. Amerman, Dick Stanley and Scott Warren among others. Also includes some description of fishing grounds around the island, trawling, trap setting and hand lining. Middle of the book contains several pages of miscellaneous aphorisms

The Nebraska Tractor Law and Rules for Official Tractor Tests

The Nebraska Tractor Law, which became effective July 15, 1919, was enacted to encourage the manufacture and sale of improved types of tractors and to contribute to a more successful use of the tractor for farming. It was thought that the best method of accomplishing these objects would be to require a tractor of each model sold in the State to be tested at the State University and to have the results of these tests made public

A Hybrid Algorithm for Topology Optimization of Additive Manufactured Structures

Most topology (TO) algorithms involve the penalization of intricate structural features to eliminate manufacturing difficulties. Since additive manufacturing is less dependent on manufacturing constraints, it becomes necessary to adapt these algorithms for AM. We propose a hybrid algorithm consisting of an adaptive meshing strategy (AMS) and a modified form of the bidirectional evolutionary structural optimization (BESO) method. By solving a standard cantilever problem, we show that the hybrid method offers improved performance over the standard BESO method. It is proposed that the new method is more suitable for optimizing structures for AM in a computational efficient manner.Mechanical Engineerin

Large-scale circulation patterns associated with high concentrations of tropospheric ozone in the tropical South Atlantic Ocean

Several years of satellite observations indicate the presence of enhanced amounts of tropospheric ozone over the tropical South Atlantic during the austral springs. Wide-spread biomass burning is prevalent over Africa and South America during the same time of the year. Another recent satellite technique has identified the locations of fires over the continents. In this study, we present an analysis of the prevailing meteorological conditions when the highest amounts of tropospheric ozone are present

A Computational Method for Combustion in High Speed Flows

A two-dimensional time-accurate numerical model to simulate complex reacting flowfields in chemical non-equilibrium is presented. The aim of this studyis to develop a computational tool which permits the analysis and the easy implementation of combustion phenomena for high speed flows. To construct an efficient numerical tool, while maintaining a reasonable accuracy, a semi-implicit numerical method was selected and verified for a hydrogen-air mixture. The numerical approach is based on a time-dependent, finite-volume integration of the governing equations suitably modified for chemical non-equilibrium. The evaluation of the reacting constants based on Gibbs free energy and the Van't Hoff equation allows a very easy implementation of the chemical model used, regardless of its complexity. Calculations were performed with adeguate temporal and spatial resolution for modeling the physical process for pratical calculation. Comparisons with numerical results are used for a verification of the numerical procedur

Sensors for ceramic components in advanced propulsion systems

This report includes: (1) a survey of the current methods for the measurement of surface temperature of ceramic materials suitable for use as hot section flowpath components in aircraft gas turbine engines; (2) analysis and selection of three sensing techniques with potential to extend surface temperature measurement capability beyond current limits; and (3) design, manufacture, and evaluation of the three selected techniques which include the following: platinum rhodium thin film thermocouple on alumina and mullite substrates; doped silicon carbide thin film thermocouple on silicon carbide, silicon nitride, and aluminum nitride substrates; and long and short wavelength radiation pyrometry on the substrates listed above plus yttria stabilized zirconia. Measurement of surface emittance of these materials at elevated temperature was included as part of this effort

Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2

BACKGROUND: The discovery of TCF7L2 as a global type 2 diabetes (T2D) gene has sparked investigations to explore the clinical utility of its variants for guiding the development of new diagnostic and therapeutic strategies. However, interpreting the resulting associations into function still remains unclear. Canonical Wnt signaling regulates β-catenin and its binding with TCF7L2, which in turn is critical for the production of glucagon-like peptide-1 (GLP-1). This study examines the role of a novel frame-shift insertion discovered in a conserved region of WNT16a, and it is proposed that this mutation affects T2D susceptibility in conjunction with gene variants in TCF7L2. RESULTS: Our results predicted that the insertion would convert the upstream open reading frame in the Wnt16a mRNA to an alternative, in-frame translation initiation site, resulting in the prevention of nonsense-mediated decay, leading to a consequent stabilization of the mutated WNT16a message. To examine the role of Wnt16a in the Wnt signaling pathway, DNA and serum samples from 2,034 individuals (48% with T2D) from the Sikh Diabetes Study were used in this investigation. Prevalence of Wnt16a insertion did not differ among T2D cases (33%) and controls (32%). However, there was a 3.2 fold increase in Wnt16a mRNA levels in pancreatic tissues from the insertion carriers and a significant increase (70%, p < 0.0001) in luciferase activity in the constructs carrying the insertion. The expression of TCF7L2 mRNA in pancreas was also elevated (~23-fold) among the insertion carriers (p=0.003). CONCLUSIONS: Our results suggest synergistic effects of WNT16a insertion and the at-risk ‘T’ allele of TCF7L2 (rs7903146) for elevating the expression of TCF7L2 in human pancreas which may affect the regulation of downstream target genes involved in the development of T2D through Wnt/β-catenin/TCF7L2 signaling pathway. However, further studies would be needed to mechanistically link the two definitively