Data Management and Sharing from the Perspective of Graduate Students: An Examination of Culture and Practice at the Water Quality Field Station

Libraries are actively seeking to identify and respond to the data management and curation needs of researchers. One important perspective in this area that is often overlooked is that of graduate students. This case study uses the Data Curation Profile Toolkit to interview six graduate students working for Agronomy researchers at the Water Quality Field Station (WQFS) research lab to understand the students’ practices with data, the challenges they face, and their attitudes towards managing and sharing data. Though a small study, this research could provide new insights for libraries creating data services, particularly in regards to graduate students

Cigarette smoke extract induces a phenotypic shift in epithelial cells: involvement of HIF1α in mesenchymal transition

In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial cells, but the signaling mechanisms involved are largely unknown and subject of this study. EMT was assessed in A549 and BEAS2B cells stimulated with CSE by qPCR, Western blotting and immunofluorescence for epithelial and mesenchymal markers, as were collagen production, cell adhesion and barrier integrity as functional endpoints. Involvement of TGF-beta and HIF1 alpha signaling pathways were investigated. In addition, mouse models were used to examine the effects of CS on hypoxia signaling and of hypoxia per se on mesenchymal expression. CSE induced EMT characteristics in A549 and BEAS2B cells, evidenced by decreased expression of epithelial markers and a concomitant increase in mesenchymal marker expression after CSE exposure. Furthermore cells that underwent EMT showed increased production of collagen, decreased adhesion and disrupted barrier integrity. The induction of EMT was found to be independent of TGF-beta signaling. On the contrary, CS was able to induce hypoxic signaling in A549 and BEAS2B cells as well as in mice lung tissue. Importantly, HIF1 alpha knock-down prevented induction of mesenchymal markers, increased collagen production and decreased adhesion after CSE exposure, data that are in line with the observed induction of mesenchymal marker expression by hypoxia in vitro and in vivo. Together these data provide evidence that both bronchial and alveolar epithelial cells undergo a functional phenotypic shift in response to CSE exposure which can contribute to increased collagen deposition in COPD lungs. Moreover, HIF1 alpha signaling appears to play an important role in this process

Involving medical students in service improvement: evaluation of a student-led, extracurricular, multidisciplinary quality improvement initiative

Background: Quality improvement (QI) is considered a duty of every doctor and, as such, it is fundamental that medical schools nurture QI skills of medical students. At a London medical school, a novel initiative was designed to involve medical students in QI. Such novel aspects include its student leadership, multidisciplinary approach and extra-curricular nature. The aim of this study is to evaluate the effectiveness of the initiative, and thus add to the experiences of existing medical student QI programs, as well as provide guidance to other institutions wishing to involve medical students in QI. / Methods: The key features of the initiative’s design is described. Its effectiveness was evaluated by the collection of retrospective data on the quality of the initiative’s QI projects (QIPs), including the proportion which: 1) reached completion; 2) resulted in a significant improvement in their primary outcome; 3) had sustained results at follow-up; 4) achieved publication; and 5) contributed towards a prize or conference presentation. / Results: There were 109 students involved throughout 10 projects from 14 different undergraduate and postgraduate courses from 2015–2019. 50% of the initiative’s projects achieved a significant improvement in their primary outcome, and the proportion of projects which sustained these improvements at follow-up was 100%. Furthermore, 20% of projects were published, and 60% contributed towards a prize or conference presentation. / Conclusion: The results of this study show that the initiative was effective at involving medical students in QI. As such, other groups establishing medical student QI programs may benefit from replicating positive elements of its design and operation

Does a voucher program improve reproductive health service delivery and access in Kenya?

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Background - Current assessments on Output-Based Aid (OBA) programs have paid limited attention to the experiences and perceptions of the healthcare providers and facility managers. This study examines the knowledge, attitudes, and experiences of healthcare providers and facility managers in the Kenya reproductive health output-based approach voucher program. Methods - A total of 69 in-depth interviews with healthcare providers and facility managers in 30 voucher accredited facilities were conducted. The study hypothesized that a voucher program would be associated with improvements in reproductive health service provision. Data were transcribed and analysed by adopting a thematic framework analysis approach. A combination of inductive and deductive analysis was conducted based on previous research and project documents. Results - Facility managers and providers viewed the RH-OBA program as a feasible system for increasing service utilization and improving quality of care. Perceived benefits of the program included stimulation of competition between facilities and capital investment in most facilities. Awareness of family planning (FP) and gender-based violence (GBV) recovery services voucher, however, remained lower than the maternal health voucher service. Relations between the voucher management agency and accredited facilities as well as existing health systems challenges affect program functions. Conclusions - Public and private sector healthcare providers and facility managers perceive value in the voucher program as a healthcare financing model. They recognize that it has the potential to significantly increase demand for reproductive health services, improve quality of care and reduce inequities in the use of reproductive health services. To improve program functioning going forward, there is need to ensure the benefit package and criteria for beneficiary identification are well understood and that the public facilities are permitted greater autonomy to utilize revenue generated from the voucher program.This work was supported by the Bill and Melinda Gates Foundation to the Population Council as part of a multi country study evaluation of voucher-andaccreditation interventions. Grant number 51761

The New RF Control System for the CERN SPS Accelerator

The old SPS RF control system designed in 1972 has been replaced completely, i.e. both hardware and software. The new system has to control both RF equipment conceived during the last 23 years and future (modern) equipment. Using information analysis methods, we derived a model of an RF command and designed a data base accordingly (ORACLE®). Information from this data base is used for command generation and processing and also for archiving settings. The advantage is purely generic software, i.e. the same computer code is used for switching on an RF amplifier, as for setting a frequency synthesizer. New equipment is added very simply by entering new records in the data base. Additional features include a reservation scheme whereby a user can take private control of any piece of equipment, a reporting facility notifying the user of the simultaneous control activity by other users on RF equipment, and a capability scheme assigning a level of expertise to each user restricting action on the equipment

Thermo-mechanical behavior of a granodiorite from the Liquiñe fractured geothermal system (39°S) in the Southern Volcanic Zone of the Andes

Fractures and faults in granitic rocks play an important role in geothermal systems because they permit the circulation of hot fluids. However, the thermo-hydro-mechanical behavior of granitic rocks has predominantly been studied at temperatures exceeding 300 °C but many geothermal systems experience temperatures much lower than this. The aim of this study was to evaluate how the depth, temperature, and amount and rate of mechanical loading associated conditions, that are realistic in low temperature geothermal system, influence the physical properties of geothermal reservoir hosting rock. We carried out both room temperature and low temperature thermo-mechanical tests on a granodiorite sample from the Liquiñe area, Chile, and performed post-experimental X-ray microtomography analysis to numerically estimate the permeability of the generated fractures. The results showed that both rock strength and rock stiffness decreased with increments of temperature treatment related to the development of thermal crack damage at temperatures > 150 °C and through the development of sub-critical cracking at constant temperatures between 50–75 °C. Slowest deformed samples also exhibited lower strengths, attributed to the development of sub-critical cracking. The cyclic triaxial loading test indicated that significant mechanical fracture damage was only initiated above 80% of the peak stress regardless of the number of repeated loading cycles at lower stresses. Low-temperature treatment appears to be a conditioning factor, but not the dominant factor in controlling the physical properties of reservoir hosting rocks. Our findings indicate that thermal crack damage is likely important for developing microfracture related permeability at depths between around 2–6 km where the temperature is sufficiently high to induce thermal cracking. At shallower depths, such was previously estimated the reservoir of Liquiñe, thermal crack damage is only generated adjacent to fractures that remain open and circulate the hot fluids but sub-critical cracking over time reduces the strength of rocks in lower temperature regimes. These processes combined to produce a geothermal reservoir in Liquiñe which likely first required the presence of a highly fractured fault zone

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact