Implementation of the Chicago sum frequency laser at Palomar laser guide star test bed

Work is underway at the University of Chicago and Caltech Optical Observatories to implement a sodium laser guide star adaptive optics system for the 200 inch Hale telescope at Palomar Observatory. The Chicago sum frequency laser (CSFL) consists of two pulsed, diode-pumped, mode-locked Nd:YAG lasers working at 1.064 micron and 1.32 micron wavelengths. Light from the two laser beams is mixed in a non-linear crystal to produce radiation centered at 589 nm with a spectral width of 1.0 GHz (FWHM) to match that of the Sodium-D2 line. Currently the 1.064 micron and 1.32 micron lasers produce 14 watts and 8 watts of TEM-00 power respectively. The laser runs at 500 Hz rep. rate with 10% duty cycle. This pulse format is similar to that of the MIT-Lincoln labs and allows range gating of unwanted Rayleigh scatter down an angle of 60 degrees to zenith angle. The laser system will be kept in the Coude lab and will be projected up to a laser launch telescope (LLT) bore-sited to the Hale telescope. The beam-transfer optics, which conveys the laser beam from the Coude lab to the LLT, consists of motorized mirrors that are controlled in real time using quad-cell positioning systems. This needs to be done to prevent laser beam wander due to deflections of the telescope while tracking. There is a central computer that monitors the laser beam propagation up to the LLT, the interlocks and safety system status, laser status and actively controls the motorized mirrors. We plan to install a wide-field visible camera (for high flying aircraft) and a narrow field of view (FoV) IR camera (for low-flying aircraft) as part of our aircraft avoidance system

On-orbit servicing commercial opportunities with security implications

The On-Orbit Servicing (OOS) working group discussed legal and political implications of developing a commercial OOS industry. The group considered the benefits that OOS and Active Debris Removal (ADR) can offer the satellite industry, as well as potential disadvantages for international relations between space faring nations. To gain an accurate perspective of stakeholders involved in such a process, the OOS working group held a mock hearing for OOS licensing, with members of the working group assigned to represent stakeholders. Working group members presented their cases at a simulated domestic regulatory panel, constructed of members representing various government ministers, to fully explore stakeholder views. The mock hearings explored the challenges faced by OOS and ADR entrepreneurs as well as the benefit of regulation. The groups highlighted recommendations to ensure the practicality of OOS and determine how best to encourage licensing and regulation of such activities, as summarised below. 1. The United Nations (UN) should provide regulatory guidelines for OOS and ADR. 2. Government agencies should license OOS. The Federal Aviation Administration (FAA) has taken responsibility for licensing commercial space transportation in the United States and this should be extended to OOS/ADR missions to enable short-term advancement prior to further UN regulation. 3. Government should support OOS and ADR development to ensure continued demand. This includes leading by example on government satellites and potential launch levies to enable on-going ADR funding. 4. All stakeholders should prevent weaponisation of space through transparency of operations. 5. Nations should initiate international cooperation on ADR. OOS and ADR will ensure sustainable use of satellites, particularly in LEO and GEO, for the coming decades. It is through transparency, economic stimulation and close monitoring that such endeavours will be successful

Activation of silicon towards hydrogen generation by pelletisation

One of the barriers to the use of the silicon-water reaction to generate hydrogen for hydrogen fuel cells in portable devices is the lengthy induction period of the reaction caused by the presence of the native oxide layer on the surface of the silicon. Herein is presented a simple pelleting process which can be used to effectively eliminate the induction period in the reaction of pressed silicon powders with 2 wt% sodium hydroxide solution by means of disrupting the native oxide layer. The activation energy of the reaction was found to be 73 kJ/mol by means of an Arrhenius plot. It was also found that the rate of reaction of hydrogen generation could be enhanced by mixing sodium chloride and sodium polyacrylate with the silicon powder before pressing

Implementation of the Chicago sum frequency laser at Palomar laser guide star test bed

Work is underway at the University of Chicago and Caltech Optical Observatories to implement a sodium laser guide star adaptive optics system for the 200 inch Hale telescope at Palomar Observatory. The Chicago sum frequency laser (CSFL) consists of two pulsed, diode-pumped, mode-locked Nd:YAG lasers working at 1.064 micron and 1.32 micron wavelengths. Light from the two laser beams is mixed in a non-linear crystal to produce radiation centered at 589 nm with a spectral width of 1.0 GHz (FWHM) to match that of the Sodium-D2 line. Currently the 1.064 micron and 1.32 micron lasers produce 14 watts and 8 watts of TEM-00 power respectively. The laser runs at 500 Hz rep. rate with 10% duty cycle. This pulse format is similar to that of the MIT-Lincoln labs and allows range gating of unwanted Rayleigh scatter down an angle of 60 degrees to zenith angle. The laser system will be kept in the Coude lab and will be projected up to a laser launch telescope (LLT) bore-sited to the Hale telescope. The beam-transfer optics, which conveys the laser beam from the Coude lab to the LLT, consists of motorized mirrors that are controlled in real time using quad-cell positioning systems. This needs to be done to prevent laser beam wander due to deflections of the telescope while tracking. There is a central computer that monitors the laser beam propagation up to the LLT, the interlocks and safety system status, laser status and actively controls the motorized mirrors. We plan to install a wide-field visible camera (for high flying aircraft) and a narrow field of view (FoV) IR camera (for low-flying aircraft) as part of our aircraft avoidance system

Moyal star product approach to the Bohr-Sommerfeld approximation

The Bohr-Sommerfeld approximation to the eigenvalues of a one-dimensional quantum Hamiltonian is derived through order $\hbar^2$ (i.e., including the first correction term beyond the usual result) by means of the Moyal star product. The Hamiltonian need only have a Weyl transform (or symbol) that is a power series in $\hbar$, starting with $\hbar^0$, with a generic fixed point in phase space. The Hamiltonian is not restricted to the kinetic-plus-potential form. The method involves transforming the Hamiltonian to a normal form, in which it becomes a function of the harmonic oscillator Hamiltonian. Diagrammatic and other techniques with potential applications to other normal form problems are presented for manipulating higher order terms in the Moyal series.Comment: 27 pages, no figure

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Crossdating and analysis of eucalypt tree rings exhibiting terminal and reverse latewood

We investigated crossdating and climate sensitivity in tree-ring series from Eucalyptus delegatensis Baker, R.T. and E. obliqua L'Herit. We first visually crossdated the measured ring width series and then independently verified this crossdating using Xmatch and cross-correlation significance tests. Crossdating was verified in 28 of the 32 study trees. Crossdating success differed between E. delegatensis and E. obliqua. In E. delegatensis crossdating success appears to be related to tree dominance and elevation. In E. obliqua radial azimuth appears to affect crossdating success. We developed two chronologies for each of the species studied. The first of these chronologies was based on all visually crossdated radii and the other on radii for which crossdating had been independently verified. Signal strength was higher in the verified chronologies. Correlation analysis between the verified chronologies and climate data revealed no significant correlation between precipitation and ring width for either species. E. obliqua ring width was significantly correlated with mean minimum and maximum air temperature and vapour pressure deficit during summer of the growing season. The E. delegatensis chronology was significantly correlated with air temperature and frequency of frost during the preceding winter. Ring width in both species was significantly correlated with air temperature during the preceding summer. Potential physiological explanations for these results are discussed. Further study is required to verify the results of climatological analysis and to explore the causes of variation in signal strength within and between trees

The effect of age and sample position on eucalypt tree-ring width series

In this study, we examine within-tree variance in proportionate tree-ring width (prw) and correlation between radii (rwt), samples (rbh), and trees (rbt) in four eucalypt species common throughout eastern Victoria, Australia. In all species and sites studied, r wt and rbh differ significantly between cambial-age and sample-height classes. Differences between rwt and rbh are nonsignificant between tree-age or radial-azimuth classes. Significant differences in prw exist between cambial-age, tree-age, and sample-height classes and between radii on different compass bearings. Whilst differences in rwt and rbh between cambial-age classes appears to be the result of variation in mechanical demands with increasing stem size, stem deformation may account for differences between sample-height classes. Variation in prw appears to be due to stem geometry, stem eccentricities associated with root buttressing, and tree-age dependent variation in the rate of radial growth. No significant differences in rbt exist between sample-height classes. Analysis of the expressed population signal statistic indicates that site-level and species differences are far more significant than sample position on variance within tree-ring width series collected from eucalypts. We discuss the implications of the current work for eucalypt dendroclimatology