Uber die Synthese von XeF6

Claassen und Mitarb.1 berlichten iiber die Syinthese von XeF4 , R. Hoppe und Mifarb.2 iiber die Synthese von XeF2 • Wir haiben die Synthese VO!!l XeF43 reproduzii.ert und koomten bei der massenspektrometrischen Analyse des Produktes schwache Andeutungen fiir die .Ainwesenheit hoherer Fluoride feststellen

10.34: Creep properties of grade S275JR steel at high temperature

The paper describes an ongoing research project which aims to determine the creep properties of European steel Grade 275JR. The purpose of the research is to develop a reliable temperature‐, stress‐ and time‐dependent creep model for this alloy, since there is very little information available in the scientific community regarding its creep properties. The research within the project is focused on a series of stationary creep tests, which will be used to obtain time‐dependent creep strains in the temperature range 400–600°C. The stress range for which the creep evolution is studied in this project is between 25% and 90% of the value of the stress at 0.2% strain at any particular temperature level. Comparisons between the creep output for the alloy analysed and existing creep data are presented in the paper

Microgreens and germs: The gleam of next-generation super foods - manipulations in production technologies and future strategies for maintaining the shelf life and quality of products

Considering the well-being cognizance of masses, microgreens and germs have emerged as potential therapeutic functional foods for improving overall health by dietary supplementation. Microgreens and germs have an exceptional volume of various nutrients accounting for higher nutritive benefits compared to their mature counterparts [1]. These plants are difficult to store in fresh, due to their high surface area to volume ratio, high respiration rate, delicate leaves that easily wilt, rapid post-harvest decay transpiration, leakage of nutrient-rich exudates, tissue damage, and early senescence [1]. Therefore, within this study, the effect of drying on the sugar content of 12 samples of different microgreens and germs was monitored. A comparative study of the content of vitamin C and sugar between samples of microgreens and germs in both dry and fresh states was also done. The content of vitamin C was determined by the HPLC method, while the sugar profile was obtained using HPAEC-PAD. The results showed that there was a difference between samples of microgreens and germs (fig. 1), as well as the contents of vitamin C and sugar in the samples are inversely proportional (fig. 2), which is in line with the fact that part of the sugar is converted into vitamin C during ripening, which then serves as an antioxidant and protects against harmful effects [2]. Analyzes also showed that dry samples have a higher sugar content compared to fresh ones (fig.2.), which could serve as an argument to promote cost-effective production and future strategies for maintaining the shelf life and quality of these products in the sense that they do not lose their nutritional value during the drying process. Fig.1. Principal Component Analysis - The difference between microgreens and germs; score plot (A) – germ samples (G) 1-6, microgreen (MG) samples 7-12, and loading plot (B). Fig.2. Content of vitamin C (A) and sugars (B) in dry and fresh samples of microgreens (MG) and germs (G). Acknowledgments: The authors would like to thank the Grina - klico kutak corporation for technical support in the procurement of materials used for experiments. This work has been supported by the Ministry of Education, Science and Technological Development of Republic of Serbia, Contract number: 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.) References: [1] B. P. K. Naik, G. Sekhar, A. Suryakumari, G. S. G. Rajulu, K. Harshini, L.A.S: Deepika, International Journal of Research in Agronomy, 5(1) 2022; 40-42 [2] S. Kathi, H. Laza, S. Singh, L. Thompson, W. Li, C. Simpson, Scientific reports,12(1) 2022, 13093

Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide approaches. We performed a genome-wide association study (GWAS) and polygenic risk score analysis in a Greek sample collection (GOMAP) comprising three patient groups: SCZ only (n = 924), T2D only (n = 822), comorbid SCZ and T2D (n = 505); samples from two separate Greek cohorts were used as population-based controls (n = 1,125). We used genome-wide summary statistics from two large-scale GWAS of SCZ and T2D from the PGC and DIAGRAM consortia, respectively, to perform genetic overlap analyses, including a regional colocalisation test. We show for the first time that patients with comorbid SCZ and T2D have a higher genetic predisposition to both disorders compared to controls. We identify five genomic regions with evidence of colocalising SCZ and T2D signals, three of which contain known loci for both diseases. We also observe a significant excess of shared association signals between SCZ and T2D at nine out of ten investigated p value thresholds. Finally, we identify 29 genes associated with both T2D and SCZ, several of which have been implicated in biological processes relevant to these disorders. Together our results demonstrate that the observed comorbidity between SCZ and T2D is at least in part due to shared genetic mechanisms. © 2018, The Author(s)

Spectroscopic substellar initial mass function of NGC 2244

Context. The dominant formation channel of brown dwarfs (BDs) is not well constrained yet and a promising way to discriminate between scenarios is to test the environment-dependent efficiency in forming BDs. So far, the outcome of star formation, studied through the initial mass function, has been found to be very similar in all clusters that have been inspected. Aims. We aim to characterize the low-mass (sub)stellar population of the central portion (2.4 pc2) of the ∼2 Myr old cluster NGC 2244 using near-infrared spectroscopy. By studying this cluster, characterized by a low stellar density and numerous OB stars, we aim to explore the effect that OB stars may have on the production of BDs. Methods. We obtained near-infrared HK spectroscopy of 85 faint candidate members of NGC 2244. We derived the spectral type and extinction by comparison with spectral templates. We evaluated cluster membership using three gravity-sensitive spectral indices based on the shape of the H-band. Furthermore, we evaluated the infrared excess from Spitzer of all the candidate members of the cluster. Finally, we estimated the mass of all the candidate members of the cluster and derived the initial mass function, star-to-BD number ratio, and disk fraction. Results. The initial mass function is well represented by a power law (dN/dM ∝ M−α) below 0.4 M⊙, with a slope α = 0.7–1.1 depending on the fitted mass range. We calculated a star-to-BD number ratio of 2.2–2.8. We find the low-mass population of NGC 2244 to be consistent with nearby star-forming regions, although it is at the high end of BD production. We find BDs in NGC 2244 to be, on average, closer to OB stars than to low-mass stars, which could potentially be the first piece of evidence that OB stars affect the formation of BDs. We find a disk fraction of all the members with a spectral type later than K0 of 39 ± 9% which is lower than typical values found in nearby star-forming regions of similar ages

Reproducibility of histological subtyping of malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This study assessed prognostic significance and interobserver agreement in MPM subtyping of small biopsy specimens. We analyzed biopsy specimens, and clinical and survival data from records of 108 patients who were diagnosed between 2000 and 2010 at the Institute of Pathology University of Zagreb School of Medicine, of whom 98 had epithelioid MPM, six biphasic MPM, and four sarcomatoid MPM. Among epithelioid subtypes, 44 (44.9 %) were solid, 19 (19.4 %) tubulopapillary, 18 (18.4 %) acinar, six (6.1 %) adenomatoid, five (5.1 %) pleomorphic, four (4.1 %) trabecular, and two (2.0 %) micropapillary subtype. Interobserver reliability for histological diagnosis was found to be κ = 0.72 (P < 0.001). Median overall survival for epithelioid MPM was 10.5 months with an interquartile range (IQR) of 5.8-28.0 months but significantly shorter for the pleomorphic subtype (3 [IQR 3.0-8.0] months; P = 0.034), but not significantly different from biphasic (6.5 [IQR 3.5-15.3] months) and sarcomatoid mesothelioma (4.0 [IQR 1.3-6.8] months; P = 0.270). We found strong reproducibility of MPM subtyping with good interobserver agreement. Furthermore, our results indicate that pleomorphic subtype to be a predictor of poor prognosis and support classifying it with sarcomatoid or biphasic MPM, as patients with the pleomorphic, biphasic, or sarcomatoid subtype show similarly poor overall survival

Tracing widespread Early Miocene ignimbrite eruptions and petrogenesis at the onset of the Carpathian-Pannonian Region silicic volcanism

The Carpathian-Pannonian Region (CPR) hosted some of the largest silicic volcanic eruptions in Europe during the Early and Middle Miocene, contemporaneously with major lithospheric thinning of the Pannonian Basin. This was recorded as an ignimbrite flare-up event from approximately 18.1–14.4 Ma. To gain in-depth perspectives on the eruption chronology, tephrostratigraphy, and petrogenesis at the onset of CPR silicic volcanism, we applied a multi-proxy approach to Lower Miocene rhyolitic ignimbrites and pyroclastic fall deposits from the northern CPR to the Dinaride Lake System. High-precision zircon U-Pb geochronology distinguished two Lower Miocene groups of volcaniclastic rocks at ∼ 18.1 Ma and ∼ 17.3 Ma. Based on combined tephrostratigraphic signatures we propose that the ∼ 18.1 Ma Kalnik and ∼ 17.3 Ma Eger eruptions produced widespread (intermediate to) large caldera-forming massive rhyolitic ignimbrites, deposited across northern and southwestern regions of the CPR. Due to easterly winds that carried volcanic ash hundreds of kilometers to the southwest, Eger eruption products also reached distal intra-montane Dinaride lacustrine basins, recorded as pyroclastic fall deposits. Heterogeneous major and trace elemental compositions of ∼ 18.1 Ma volcanic glass shards suggest that the Kalnik eruption was sourced from complex silicic magmatic systems, with simultaneous tapping of two discrete melt bodies during the eruption. The homogeneous geochemical composition of ∼ 17.3 Ma glasses is distinct from the older glasses. Integrated zircon and bulk glass Nd-Hf isotope compositions have a positive correlation, defining a regional mantle array, and are more radiogenic in the younger phase of volcanism. The recorded systematic isotopic change, moving from older more crustal signatures to younger more juvenile compositions, imply that during the period of lithospheric thinning of the Pannonian Basin the region underwent more complex variations in the interaction between metasomatized lithospheric mantle-derived magmas and various crustal components than previously recognized