Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer

Tables not included in the main manuscript have been listed. Table S1. Number of probe sets affected by AZA treatment; Table S2. Comparison of significantly altered probe sets with the independent study GSE20713 Dataset; Table S3. Cancer vs. normal analysis of TAGLN mRNA in Oncomine database. (PDF 18 kb

A protuberant nodule under the foot

WOS: 000254999300017PubMed: 18427056

Rare Localizations of Basal Cell Carcinoma: Lower Lip and Popliteal Area

WOS: 000413898100006In this report, we describe two cases of basal cell carcinoma (BCC), one of them is on the lower lip and the other is on the popliteal area. A 45-year-old male patient with an unhealed wound on the lower lip and a 38-year-old male patient with an unhealed wound over the popliteal skin were admitted to our clinic. There was no sun exposure and trauma in their medical history. A biopsy was taken from each case. The results were BCC in two patients. BCC is usually seen in the head and neck regions, but it may be also localized in rare areas such as the lower lip and lower extremity. These unpredictable areas should be considered for tumor surgery

Acute actinic cheilitis-like chemical irritant reaction following accidental contact with ethylene glycol - Favorable response to topical 1% pimecrolimus cream: A case report

WOS: 000257028200005PubMed: 18568894Ethylene glycol is a colorless, odorless, nonvolatile, water-soluble fluid, mainly used as automobile antifreeze and coolant. This substance is a frequent culprit in accidental and intentional poisonings. Although potentially fatal systemic consequences of ethylene glycol ingestion are well known, local adverse effects through brief skin and mucosa contact with ethylene glycol have been rarely reported. Herein we report a patient with accidental ethylene glycol contact to the lower lip, who presented with acute, manifest, actinic cheilitis-like chemical irritant reaction and favorably responded to topical pimecrolimus 1% cream

A Case of Brucellosis Presenting With Widespread Maculopapular Rash

WOS: 000270537600012PubMed: 19668075Human brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas

Generalized livedo reticularis like eruption induced Generalized livedo reticularis like eruption induced by trimethoprim/sulfamethoxazole: A case report with by trimethoprim/sulfamethoxazole: A case report with concomitant myelosuppression

Livedo reticularis is a reticular discoloration of the skin because of the vascular anatomy of the skin. The condition most commonly affects the legs. Drug induced livedo reticularis which is an acknowledged side effect of amantadine, tends to be widespread, asymptomatic, benign rash. There are also reports of livedoid eruption induced with drugs including dapsone, imatinibe, gefitinibe. We describe a case of livedo reticularis like eruption and haemotological toxicity with trimetophrim-sulfamethoxazole. The purpose of this report is to remind clinicians of this rare, benign side effect of the common prescribed medication

Hypoxic Gene Signature of Primary and Metastatic Melanoma Cell Lines: Focusing on HIF-1 beta and NDRG-1

WOS: 000503405700004PubMed: 31594284Background: Hypoxia is an important microenviromnental factor significantly affecting tumor proliferation and progression. The importance of hypoxia is, however, not well known in oncogenesis of malignant melanoma. Aims: To evaluate the difference of hypoxic gene expression signatures in primary melanoma cell lines and metastatic melanoma cell lines and to find the expression changes of hypoxia-related genes in primary melanoma cell lines at experimental hypoxic conditions Study Design: Cell study. Methods: The mRNA expression levels of hypoxia-related genes in primary melanoma cell lines and metastatic melanoma cell lines and at experimental hypoxic conditions in primary melanoma cell lines were evaluated by using real-time polymerase chain reaction. Depending on the experimental data, we focused on two genes/proteins, the hypoxia-inducible factor-1 beta and the N-myc downstream regulated gene-I. The expression levels of the two proteins were investigated by immunohistochemistty methods in 16 primary and metastatic melanomas. 10 intradermal nevi, and a commercial tissue array comprised of 208 cores including 192 primary and metastatic malignant melanomas. Results: The real-time polymerasc chain reaction study showed that hypoxic gene expression signature was different between metastatic melanoma cell lines and primary melanoma cell lines. Hypoxic experimental conditions significantly affected the hypoxic gene expression signature. In immunohistochemical study, N-myc downstream regulated gene-I expression was found to be lower in primary cutaneous melanoma compared to in intradermal nevi (p 0.001). In contrast, the cytoplasmic expression of hypoxia-inducible factor-1 beta was higher in primary cutaneous melanoma than in intradermal nevi (p=0.001). We also detected medium/strong significant correlations between the two proteins studied in the study groups. Conclusion: Hypoxic response consists of closely related proteins in more complex pathways. These findings will shed light on hypoxic processes in melanoma and unlock a Pandora's box for development of new therapeutic strategies.Kirikkale University Scientific Research Project UnitKirikkale University [2012/59]The presented research was supported by Kirikkale University Scientific Research Project Unit (project no: 2012/59)

Clinicopathologic challenge: Linear brown macules on the chest and arm

WOS: 000255833200001PubMed: 18477139What is your diagnosis